{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1944921593",
  "communityStandardTitle": [
    "NM_002412.5(MGMT):c.427A= (p.Ile143=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/2308321",
        "rs": 2308321
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "A",
          "end": 129766800,
          "referenceAllele": "A",
          "start": 129766799
        }
      ],
      "hgvs": [
        "NC_000010.11:g.129766800A=",
        "CM000672.2:g.129766800A="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000058"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "A",
          "end": 131565064,
          "referenceAllele": "A",
          "start": 131565063
        }
      ],
      "hgvs": [
        "NC_000010.10:g.131565064A=",
        "CM000672.1:g.131565064A="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000034"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "A",
          "end": 131455054,
          "referenceAllele": "A",
          "start": 131455053
        }
      ],
      "hgvs": [
        "NC_000010.9:g.131455054A="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000010"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 304617,
          "referenceAllele": "A",
          "start": 304616
        }
      ],
      "hgvs": [
        "NG_052673.1:g.304617A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS617153"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 546,
          "referenceAllele": "A",
          "start": 545
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "ENST00000306010.8:c.520A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000302111.7:p.Ile174="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS745242"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 495,
          "referenceAllele": "A",
          "start": 494
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "ENST00000651593.1:c.427A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000498729.1:p.Ile143="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS771753",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000651593.1:c.427A="
          },
          "RefSeq": {
            "hgvs": "NM_002412.5:c.427A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000498729.1:p.Ile143="
          },
          "RefSeq": {
            "hgvs": "NP_002403.3:p.Ile143="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 552,
          "referenceAllele": "A",
          "start": 551
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "ENST00000306010.7:c.520A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000302111.7:p.Ile174="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS255662"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 546,
          "referenceAllele": "A",
          "start": 545
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "NM_002412.3:c.520A="
      ],
      "proteinEffect": {
        "hgvs": "NP_002403.2:p.Ile174="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246853"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 552,
          "referenceAllele": "A",
          "start": 551
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "NM_002412.4:c.520A="
      ],
      "proteinEffect": {
        "hgvs": "NP_002403.2:p.Ile174="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS027717"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 589,
          "referenceAllele": "A",
          "start": 588
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "XM_005252682.2:c.427A="
      ],
      "proteinEffect": {
        "hgvs": "XP_005252739.1:p.Ile143="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS060032"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 448,
          "referenceAllele": "A",
          "start": 447
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "XM_006717863.2:c.250A="
      ],
      "proteinEffect": {
        "hgvs": "XP_006717926.1:p.Ile84="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072351"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 512,
          "referenceAllele": "A",
          "start": 511
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "XM_011539817.1:c.436A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011538119.1:p.Ile146="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106767"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3076680326",
      "coordinates": [
        {
          "allele": "A",
          "end": 495,
          "referenceAllele": "A",
          "start": 494
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "NM_002412.5:c.427A="
      ],
      "proteinEffect": {
        "hgvs": "NP_002403.3:p.Ile143="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS524990",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000651593.1:c.427A="
          },
          "RefSeq": {
            "hgvs": "NM_002412.5:c.427A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000498729.1:p.Ile143="
          },
          "RefSeq": {
            "hgvs": "NP_002403.3:p.Ile143="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 375,
          "referenceAllele": "A",
          "start": 374
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007059",
      "geneNCBI_id": 4255,
      "geneSymbol": "MGMT",
      "hgvs": [
        "XM_017016275.1:c.250A="
      ],
      "proteinEffect": {
        "hgvs": "XP_016871764.1:p.Ile84="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568765"
    }
  ],
  "type": "nucleotide"
}