{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1905813069",
  "communityStandardTitle": [
    "NM_020975.6(RET):c.1852T= (p.Cys618=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/76262710",
        "rs": 76262710
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "T",
          "end": 43113648,
          "referenceAllele": "T",
          "start": 43113647
        }
      ],
      "hgvs": [
        "NC_000010.11:g.43113648T=",
        "CM000672.2:g.43113648T="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000058"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "T",
          "end": 43609096,
          "referenceAllele": "T",
          "start": 43609095
        }
      ],
      "hgvs": [
        "NC_000010.10:g.43609096T=",
        "CM000672.1:g.43609096T="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000034"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "T",
          "end": 42929102,
          "referenceAllele": "T",
          "start": 42929101
        }
      ],
      "hgvs": [
        "NC_000010.9:g.42929102T="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000010"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 41580,
          "referenceAllele": "T",
          "start": 41579
        }
      ],
      "hgvs": [
        "NG_007489.1:g.41580T=",
        "LRG_518:g.41580T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000611"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1629,
          "referenceAllele": "T",
          "start": 1628
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000615310.5:c.1456T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480088.2:p.Cys486="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS826472"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1426,
          "referenceAllele": "T",
          "start": 1425
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000683007.1:n.1426T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS827994"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 613,
          "referenceAllele": "T",
          "start": 612
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000683872.1:n.613T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS828839"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2042,
          "referenceAllele": "T",
          "start": 2041
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000340058.6:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000344798.4:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS747868"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2042,
          "referenceAllele": "T",
          "start": 2041
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000355710.8:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000347942.3:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748710",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000355710.8:c.1852T="
          },
          "RefSeq": {
            "hgvs": "NM_020975.6:c.1852T="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000347942.3:p.Cys618="
          },
          "RefSeq": {
            "hgvs": "NP_066124.1:p.Cys618="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1409,
          "referenceAllele": "T",
          "start": 1408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000671844.1:c.*446T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000500541.1:n.*446T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773184"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 852,
          "referenceAllele": "T",
          "start": 851
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000672389.1:c.*446T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000500252.1:n.*446T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773367"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2032,
          "referenceAllele": "T",
          "start": 2031
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000340058.5:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000344798.4:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247408"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2084,
          "referenceAllele": "T",
          "start": 2083
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000355710.7:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000347942.3:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247251"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 588,
          "referenceAllele": "T",
          "start": 587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000498820.5:c.403T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000419080.1:p.Cys135="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247185"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1479,
          "endIntronDirection": "+",
          "endIntronOffset": 2416,
          "referenceAllele": "T",
          "start": 1479,
          "startIntronDirection": "+",
          "startIntronOffset": 2415
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "ENST00000615310.4:c.1289+2416T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480088.1:n.1289+2416T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402558"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3076689766",
      "coordinates": [
        {
          "allele": "T",
          "end": 2042,
          "referenceAllele": "T",
          "start": 2041
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020630.4:c.1852T=",
        "LRG_518t2:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "NP_065681.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS036456"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3089128361",
      "coordinates": [
        {
          "allele": "T",
          "end": 2042,
          "referenceAllele": "T",
          "start": 2041
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020975.4:c.1852T=",
        "LRG_518t1:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "NP_066124.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS036733"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2084,
          "referenceAllele": "T",
          "start": 2083
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "XM_011540027.1:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "XP_011538329.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106977"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1447,
          "referenceAllele": "T",
          "start": 1446
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_001355216.1:c.1090T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001342145.1:p.Cys364="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522845"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3076689766",
      "coordinates": [
        {
          "allele": "T",
          "end": 2084,
          "referenceAllele": "T",
          "start": 2083
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020630.5:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "NP_065681.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525983"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3089128361",
      "coordinates": [
        {
          "allele": "T",
          "end": 2084,
          "referenceAllele": "T",
          "start": 2083
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020975.5:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "NP_066124.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS526025"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3089128361",
      "coordinates": [
        {
          "allele": "T",
          "end": 2042,
          "referenceAllele": "T",
          "start": 2041
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020975.6:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "NP_066124.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS670171",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000355710.8:c.1852T="
          },
          "RefSeq": {
            "hgvs": "NM_020975.6:c.1852T="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000347942.3:p.Cys618="
          },
          "RefSeq": {
            "hgvs": "NP_066124.1:p.Cys618="
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA3076689766",
      "coordinates": [
        {
          "allele": "T",
          "end": 2042,
          "referenceAllele": "T",
          "start": 2041
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020630.6:c.1852T="
      ],
      "proteinEffect": {
        "hgvs": "NP_065681.1:p.Cys618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS728447"
    }
  ],
  "type": "nucleotide"
}