{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1877495321",
  "communityStandardTitle": [
    "NM_000962.4(PTGS1):c.323G= (p.Arg108=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/5787",
        "rs": 5787
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "9",
      "coordinates": [
        {
          "allele": "G",
          "end": 122378544,
          "referenceAllele": "G",
          "start": 122378543
        }
      ],
      "hgvs": [
        "NC_000009.12:g.122378544G=",
        "CM000671.2:g.122378544G="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000057"
    },
    {
      "chromosome": "9",
      "coordinates": [
        {
          "allele": "G",
          "end": 125140823,
          "referenceAllele": "G",
          "start": 125140822
        }
      ],
      "hgvs": [
        "NC_000009.11:g.125140823G=",
        "CM000671.1:g.125140823G="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000033"
    },
    {
      "chromosome": "9",
      "coordinates": [
        {
          "allele": "G",
          "end": 124180644,
          "referenceAllele": "G",
          "start": 124180643
        }
      ],
      "hgvs": [
        "NC_000009.10:g.124180644G="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000009"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 12595,
          "referenceAllele": "G",
          "start": 12594
        }
      ],
      "hgvs": [
        "NG_032900.1:g.12595G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS005265"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 384,
          "referenceAllele": "G",
          "start": 383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000362012.7:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000354612.2:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS749581",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000362012.7:c.323G="
          },
          "RefSeq": {
            "hgvs": "NM_000962.4:c.323G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000354612.2:p.Arg108="
          },
          "RefSeq": {
            "hgvs": "NP_000953.2:p.Arg108="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 352,
          "referenceAllele": "G",
          "start": 351
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000373698.7:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000362802.5:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS751291"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 220,
          "referenceAllele": "G",
          "start": 219
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000426608.6:c.206G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000411606.2:p.Arg69="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS755144"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 839,
          "referenceAllele": "G",
          "start": 838
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000540753.6:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000437709.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS759645"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 369,
          "referenceAllele": "G",
          "start": 368
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000619306.5:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000483540.2:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS762223"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 417,
          "referenceAllele": "G",
          "start": 416
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000643576.1:n.417G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS767352"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 629,
          "referenceAllele": "G",
          "start": 628
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000643810.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000494717.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS767484"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 490,
          "referenceAllele": "G",
          "start": 489
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000645132.1:n.490G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS768188"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 354,
          "referenceAllele": "G",
          "start": 353
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000647067.1:c.*168G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000495728.1:n.*168G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769216"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 328,
          "referenceAllele": "G",
          "start": 327
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000223423.8:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000223423.4:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS248448"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 328,
          "referenceAllele": "G",
          "start": 327
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000362012.6:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000354612.2:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS265754"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 352,
          "referenceAllele": "G",
          "start": 351
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000373698.6:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000362802.5:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS269840"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 197,
          "referenceAllele": "G",
          "start": 196
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000426608.5:c.197G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000411606.1:p.Arg66="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS289299"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 851,
          "referenceAllele": "G",
          "start": 850
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000540753.5:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000437709.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS362569"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 403,
          "referenceAllele": "G",
          "start": 402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000614910.4:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484800.1:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402402"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 416,
          "referenceAllele": "G",
          "start": 415
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000619306.4:c.416G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000483540.1:p.Arg139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404328"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075608509",
      "coordinates": [
        {
          "allele": "G",
          "end": 403,
          "referenceAllele": "G",
          "start": 402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_000962.3:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000953.2:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006985"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 403,
          "referenceAllele": "G",
          "start": 402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271164.1:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258093.1:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020505"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 352,
          "referenceAllele": "G",
          "start": 351
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271165.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258094.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020506"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 629,
          "referenceAllele": "G",
          "start": 628
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271166.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258095.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020507"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 374,
          "referenceAllele": "G",
          "start": 373
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271367.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258296.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020527"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 851,
          "referenceAllele": "G",
          "start": 850
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271368.1:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258297.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020528"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 403,
          "referenceAllele": "G",
          "start": 402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_080591.2:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "NP_542158.1:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS040176"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 578,
          "referenceAllele": "G",
          "start": 577
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_005252105.2:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005252162.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059833"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 839,
          "referenceAllele": "G",
          "start": 838
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518875.1:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517177.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS086049"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4449,
          "referenceAllele": "G",
          "start": 4448
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518876.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517178.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS086050"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 578,
          "referenceAllele": "G",
          "start": 577
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_005252105.3:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005252162.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533753"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 839,
          "referenceAllele": "G",
          "start": 838
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518875.2:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517177.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS545103"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4449,
          "referenceAllele": "G",
          "start": 4448
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518876.2:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517178.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS545104"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1163,
          "referenceAllele": "G",
          "start": 1162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_024447614.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024303382.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581195"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1164,
          "referenceAllele": "G",
          "start": 1163
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_024447615.1:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024303383.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581196"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075608509",
      "coordinates": [
        {
          "allele": "G",
          "end": 384,
          "referenceAllele": "G",
          "start": 383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_000962.4:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000953.2:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662673",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000362012.7:c.323G="
          },
          "RefSeq": {
            "hgvs": "NM_000962.4:c.323G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000354612.2:p.Arg108="
          },
          "RefSeq": {
            "hgvs": "NP_000953.2:p.Arg108="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 384,
          "referenceAllele": "G",
          "start": 383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271164.2:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258093.1:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681120"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 372,
          "referenceAllele": "G",
          "start": 371
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271165.2:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258094.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681121"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 626,
          "referenceAllele": "G",
          "start": 625
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271166.2:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258095.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681122"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 355,
          "referenceAllele": "G",
          "start": 354
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271367.2:c.-5G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258296.1:n.-5G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681130"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 848,
          "referenceAllele": "G",
          "start": 847
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271368.2:c.248G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258297.1:p.Arg83="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681131"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 384,
          "referenceAllele": "G",
          "start": 383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_080591.3:c.323G="
      ],
      "proteinEffect": {
        "hgvs": "NP_542158.1:p.Arg108="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699514"
    }
  ],
  "type": "nucleotide"
}