{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1877495020",
  "communityStandardTitle": [
    "NM_000962.4(PTGS1):c.158G= (p.Arg53=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/3842789",
        "rs": 3842789
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "9",
      "coordinates": [
        {
          "allele": "G",
          "end": 122377962,
          "referenceAllele": "G",
          "start": 122377961
        }
      ],
      "hgvs": [
        "NC_000009.12:g.122377962G=",
        "CM000671.2:g.122377962G="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000057"
    },
    {
      "chromosome": "9",
      "coordinates": [
        {
          "allele": "G",
          "end": 125140241,
          "referenceAllele": "G",
          "start": 125140240
        }
      ],
      "hgvs": [
        "NC_000009.11:g.125140241G=",
        "CM000671.1:g.125140241G="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000033"
    },
    {
      "chromosome": "9",
      "coordinates": [
        {
          "allele": "G",
          "end": 124180062,
          "referenceAllele": "G",
          "start": 124180061
        }
      ],
      "hgvs": [
        "NC_000009.10:g.124180062G="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000009"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 12013,
          "referenceAllele": "G",
          "start": 12012
        }
      ],
      "hgvs": [
        "NG_032900.1:g.12013G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS005265"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 219,
          "referenceAllele": "G",
          "start": 218
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000362012.7:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000354612.2:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS749581",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000362012.7:c.158G="
          },
          "RefSeq": {
            "hgvs": "NM_000962.4:c.158G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000354612.2:p.Arg53="
          },
          "RefSeq": {
            "hgvs": "NP_000953.2:p.Arg53="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 187,
          "referenceAllele": "G",
          "start": 186
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000373698.7:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000362802.5:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS751291"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 108,
          "endIntronDirection": "-",
          "endIntronOffset": 470,
          "referenceAllele": "G",
          "start": 108,
          "startIntronDirection": "-",
          "startIntronOffset": 471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000426608.6:c.95-471G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000411606.2:n.95-471G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS755144"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 674,
          "referenceAllele": "G",
          "start": 673
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000540753.6:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000437709.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS759645"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 204,
          "referenceAllele": "G",
          "start": 203
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000619306.5:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000483540.2:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS762223"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 252,
          "referenceAllele": "G",
          "start": 251
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000643576.1:n.252G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS767352"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 464,
          "referenceAllele": "G",
          "start": 463
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000643810.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000494717.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS767484"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 325,
          "referenceAllele": "G",
          "start": 324
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000645132.1:n.325G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS768188"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 189,
          "referenceAllele": "G",
          "start": 188
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000647067.1:c.*3G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000495728.1:n.*3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769216"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 163,
          "referenceAllele": "G",
          "start": 162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000223423.8:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000223423.4:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS248448"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 163,
          "referenceAllele": "G",
          "start": 162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000362012.6:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000354612.2:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS265754"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 187,
          "referenceAllele": "G",
          "start": 186
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000373698.6:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000362802.5:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS269840"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 85,
          "endIntronDirection": "-",
          "endIntronOffset": 470,
          "referenceAllele": "G",
          "start": 85,
          "startIntronDirection": "-",
          "startIntronOffset": 471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000426608.5:c.86-471G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000411606.1:n.86-471G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS289299"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 686,
          "referenceAllele": "G",
          "start": 685
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000540753.5:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000437709.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS362569"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 238,
          "referenceAllele": "G",
          "start": 237
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000614910.4:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484800.1:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402402"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 251,
          "referenceAllele": "G",
          "start": 250
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "ENST00000619306.4:c.251G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000483540.1:p.Arg84="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404328"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075611302",
      "coordinates": [
        {
          "allele": "G",
          "end": 238,
          "referenceAllele": "G",
          "start": 237
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_000962.3:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000953.2:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006985"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 238,
          "referenceAllele": "G",
          "start": 237
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271164.1:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258093.1:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020505"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 187,
          "referenceAllele": "G",
          "start": 186
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271165.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258094.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020506"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 464,
          "referenceAllele": "G",
          "start": 463
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271166.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258095.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020507"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 209,
          "referenceAllele": "G",
          "start": 208
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271367.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258296.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020527"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 686,
          "referenceAllele": "G",
          "start": 685
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271368.1:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258297.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020528"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 238,
          "referenceAllele": "G",
          "start": 237
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_080591.2:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "NP_542158.1:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS040176"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 413,
          "referenceAllele": "G",
          "start": 412
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_005252105.2:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005252162.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059833"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 674,
          "referenceAllele": "G",
          "start": 673
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518875.1:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517177.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS086049"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4284,
          "referenceAllele": "G",
          "start": 4283
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518876.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517178.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS086050"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 413,
          "referenceAllele": "G",
          "start": 412
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_005252105.3:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005252162.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533753"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 674,
          "referenceAllele": "G",
          "start": 673
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518875.2:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517177.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS545103"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4284,
          "referenceAllele": "G",
          "start": 4283
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_011518876.2:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011517178.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS545104"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 998,
          "referenceAllele": "G",
          "start": 997
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_024447614.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024303382.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581195"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 999,
          "referenceAllele": "G",
          "start": 998
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "XM_024447615.1:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024303383.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581196"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075611302",
      "coordinates": [
        {
          "allele": "G",
          "end": 219,
          "referenceAllele": "G",
          "start": 218
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_000962.4:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000953.2:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662673",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000362012.7:c.158G="
          },
          "RefSeq": {
            "hgvs": "NM_000962.4:c.158G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000354612.2:p.Arg53="
          },
          "RefSeq": {
            "hgvs": "NP_000953.2:p.Arg53="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 219,
          "referenceAllele": "G",
          "start": 218
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271164.2:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258093.1:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681120"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 207,
          "referenceAllele": "G",
          "start": 206
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271165.2:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258094.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681121"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 461,
          "referenceAllele": "G",
          "start": 460
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271166.2:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258095.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681122"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 190,
          "referenceAllele": "G",
          "start": 189
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271367.2:c.-170G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258296.1:n.-170G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681130"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 683,
          "referenceAllele": "G",
          "start": 682
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_001271368.2:c.83G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001258297.1:p.Arg28="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681131"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 219,
          "referenceAllele": "G",
          "start": 218
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009604",
      "geneNCBI_id": 5742,
      "geneSymbol": "PTGS1",
      "hgvs": [
        "NM_080591.3:c.158G="
      ],
      "proteinEffect": {
        "hgvs": "NP_542158.1:p.Arg53="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699514"
    }
  ],
  "type": "nucleotide"
}