{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA177899574",
  "communityStandardTitle": [
    "NM_001377989.1(FAM110B):c.-413-1635G>A"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr8:g.58986459G>A?assembly=hg19",
        "id": "chr8:g.58986459G>A"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr8:g.58073900G>A?assembly=hg38",
        "id": "chr8:g.58073900G>A"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/13273891",
        "rs": 13273891
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/8-58986459-G-A?dataset=gnomad_r2_1",
        "id": "8-58986459-G-A",
        "variant": "8:58986459 G / A"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/8-58073900-G-A?dataset=gnomad_r3",
        "id": "8-58073900-G-A",
        "variant": "8:58073900 G / A"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/8-58073900-G-A?dataset=gnomad_r4",
        "id": "8-58073900-G-A",
        "variant": "8:58073900 G / A"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "A",
          "end": 58073900,
          "referenceAllele": "G",
          "start": 58073899
        }
      ],
      "hgvs": [
        "NC_000008.11:g.58073900G>A",
        "CM000670.2:g.58073900G>A"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000056"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "A",
          "end": 58986459,
          "referenceAllele": "G",
          "start": 58986458
        }
      ],
      "hgvs": [
        "NC_000008.10:g.58986459G>A",
        "CM000670.1:g.58986459G>A"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "A",
          "end": 59149013,
          "referenceAllele": "G",
          "start": 59149012
        }
      ],
      "hgvs": [
        "NC_000008.9:g.59149013G>A"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 382,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 382,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000519262.6:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000509301.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS825644",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000519262.6:c.-413-1635G>A"
          },
          "RefSeq": {
            "hgvs": "NM_001377989.1:c.-413-1635G>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000509301.1:n.-413-1635G>A"
          },
          "RefSeq": {
            "hgvs": "NP_001364918.1:n.-413-1635G>A"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 467,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 467,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000361488.7:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000355204.3:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS265504"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 181,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 181,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000518427.5:n.182-1635G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS345891"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 396,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 396,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000519262.5:n.397-1635G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS346537"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 337,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 337,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000520369.5:n.338-1635G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS347429"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 45,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 45,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000521413.1:n.46-1635G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS348239"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 88,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 88,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000522059.5:n.89-1635G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS348750"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 136,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 136,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "ENST00000523486.5:n.137-1635G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS349861"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 467,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 467,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "NM_147189.2:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_671722.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS041621"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 396,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 396,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_005251324.1:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_005251381.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059501"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 205,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 205,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_005251325.2:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_005251382.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059502"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 181,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 181,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_005251326.1:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_005251383.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059503"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 396,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 396,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_005251324.3:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_005251381.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533580"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 10624,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 10624,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_005251325.3:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_005251382.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533581"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 181,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 181,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_005251326.3:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_005251383.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533582"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 3036,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 3036,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "XM_017013948.1:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "XP_016869437.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS567074"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 498,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 498,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "NM_147189.3:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_671722.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS700086"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 382,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 382,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "NM_001377989.1:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001364918.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721365",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000519262.6:c.-413-1635G>A"
          },
          "RefSeq": {
            "hgvs": "NM_001377989.1:c.-413-1635G>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000509301.1:n.-413-1635G>A"
          },
          "RefSeq": {
            "hgvs": "NP_001364918.1:n.-413-1635G>A"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 180,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 180,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "NM_001377997.1:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001364926.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721370"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 155,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 155,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "NM_001377998.1:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001364927.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721371"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 498,
          "endIntronDirection": "-",
          "endIntronOffset": 1634,
          "referenceAllele": "G",
          "start": 498,
          "startIntronDirection": "-",
          "startIntronOffset": 1635
        }
      ],
      "gene": "http://reg.genome.network/gene/GN028587",
      "geneNCBI_id": 90362,
      "geneSymbol": "FAM110B",
      "hgvs": [
        "NM_147189.4:c.-413-1635G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_671722.1:n.-413-1635G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS729329"
    }
  ],
  "type": "nucleotide"
}