{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1777329310",
  "communityStandardTitle": [
    "NM_000025.3(ADRB3):c.280G= (p.Ala94=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1808312747",
        "rs": 1808312747
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "C",
          "end": 37966190,
          "referenceAllele": "C",
          "start": 37966189
        }
      ],
      "hgvs": [
        "NC_000008.11:g.37966190C=",
        "CM000670.2:g.37966190C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000056"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "C",
          "end": 37823708,
          "referenceAllele": "C",
          "start": 37823707
        }
      ],
      "hgvs": [
        "NC_000008.10:g.37823708C=",
        "CM000670.1:g.37823708C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "C",
          "end": 37942865,
          "referenceAllele": "C",
          "start": 37942864
        }
      ],
      "hgvs": [
        "NC_000008.9:g.37942865C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 5477,
          "referenceAllele": "G",
          "start": 5476
        }
      ],
      "hgvs": [
        "NG_011936.1:g.5477G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002062"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 410,
          "referenceAllele": "G",
          "start": 409
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.5:c.280G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Ala94="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748270",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.280G="
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.280G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Ala94="
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Ala94="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 408,
          "referenceAllele": "G",
          "start": 407
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.2:n.408G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS758684"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 776,
          "referenceAllele": "G",
          "start": 775
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.4:c.280G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Ala94="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262124"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 477,
          "referenceAllele": "G",
          "start": 476
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000614635.1:c.280G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480325.1:p.Ala94="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402283"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075169375",
      "coordinates": [
        {
          "allele": "G",
          "end": 477,
          "referenceAllele": "G",
          "start": 476
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.2:c.280G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Ala94="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006090"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075169375",
      "coordinates": [
        {
          "allele": "G",
          "end": 410,
          "referenceAllele": "G",
          "start": 409
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.3:c.280G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Ala94="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662288",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.280G="
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.280G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Ala94="
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Ala94="
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}