{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1777328483",
  "communityStandardTitle": [
    "NM_000025.3(ADRB3):c.1070G= (p.Arg357=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/952363429",
        "rs": 952363429
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "C",
          "end": 37965400,
          "referenceAllele": "C",
          "start": 37965399
        }
      ],
      "hgvs": [
        "NC_000008.11:g.37965400C=",
        "CM000670.2:g.37965400C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000056"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "C",
          "end": 37822918,
          "referenceAllele": "C",
          "start": 37822917
        }
      ],
      "hgvs": [
        "NC_000008.10:g.37822918C=",
        "CM000670.1:g.37822918C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "C",
          "end": 37942075,
          "referenceAllele": "C",
          "start": 37942074
        }
      ],
      "hgvs": [
        "NC_000008.9:g.37942075C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 6267,
          "referenceAllele": "G",
          "start": 6266
        }
      ],
      "hgvs": [
        "NG_011936.1:g.6267G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002062"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1200,
          "referenceAllele": "G",
          "start": 1199
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.5:c.1070G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Arg357="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748270",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.1070G="
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.1070G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Arg357="
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Arg357="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1198,
          "referenceAllele": "G",
          "start": 1197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.2:n.1198G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS758684"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 554,
          "referenceAllele": "G",
          "start": 553
        }
      ],
      "hgvs": [
        "ENST00000647937.1:c.554G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000497740.1:p.Arg185="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769701"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1566,
          "referenceAllele": "G",
          "start": 1565
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.4:c.1070G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Arg357="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262124"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 345,
          "referenceAllele": "G",
          "start": 344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.1:n.345G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS347406"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1267,
          "referenceAllele": "G",
          "start": 1266
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000614635.1:c.1070G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480325.1:p.Arg357="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402283"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075033687",
      "coordinates": [
        {
          "allele": "G",
          "end": 1267,
          "referenceAllele": "G",
          "start": 1266
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.2:c.1070G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Arg357="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006090"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3075033687",
      "coordinates": [
        {
          "allele": "G",
          "end": 1200,
          "referenceAllele": "G",
          "start": 1199
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.3:c.1070G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Arg357="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662288",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.1070G="
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.1070G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Arg357="
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Arg357="
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}