{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1772893348",
  "communityStandardTitle": [
    "NM_001831.4(CLU):c.246+140A="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1532278",
        "rs": 1532278
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "T",
          "end": 27608798,
          "referenceAllele": "T",
          "start": 27608797
        }
      ],
      "hgvs": [
        "NC_000008.11:g.27608798T=",
        "CM000670.2:g.27608798T="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000056"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "T",
          "end": 27466315,
          "referenceAllele": "T",
          "start": 27466314
        }
      ],
      "hgvs": [
        "NC_000008.10:g.27466315T=",
        "CM000670.1:g.27466315T="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "T",
          "end": 27522232,
          "referenceAllele": "T",
          "start": 27522231
        }
      ],
      "hgvs": [
        "NC_000008.9:g.27522232T="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 11013,
          "referenceAllele": "A",
          "start": 11012
        }
      ],
      "hgvs": [
        "NG_027845.1:g.11013A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003996"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 321,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 321,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000316403.15:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000315130.10:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS746056",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000316403.15:c.246+140A="
          },
          "RefSeq": {
            "hgvs": "NM_001831.4:c.246+140A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000315130.10:n.246+140A="
          },
          "RefSeq": {
            "hgvs": "NP_001822.3:n.246+140A="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 652,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 652,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000316403.14:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000315130.10:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS257219"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 561,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 561,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000405140.7:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385419.3:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280256"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 461,
          "referenceAllele": "A",
          "start": 460
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000518050.1:n.461A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS345584"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 412,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 412,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000519742.5:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000431026.1:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS346931"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 419,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 419,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000520491.5:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000429881.1:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS347522"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 371,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 371,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000520796.5:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000429336.1:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS347766"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 314,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 314,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000522299.5:n.314+140A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS348946"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 511,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 511,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000522413.5:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000428779.1:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS349037"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1032,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 1032,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000523500.5:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000429620.1:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS349870"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 311,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 311,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000523589.5:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000431070.1:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS349938"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 426,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 426,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "ENST00000560566.5:c.279+140A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000453247.1:n.279+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS375443"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 432,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 432,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "NM_001831.3:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001822.3:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS027160"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 567,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 567,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "NR_038335.1:n.567+140A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS050389"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 426,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 426,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "NR_045494.1:n.426+140A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS051327"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 652,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 652,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "XM_006716284.1:c.402+140A="
      ],
      "proteinEffect": {
        "hgvs": "XP_006716347.1:n.402+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS071584"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 652,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 652,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "XM_006716284.3:c.402+140A="
      ],
      "proteinEffect": {
        "hgvs": "XP_006716347.1:n.402+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539138"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 321,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 321,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "NM_001831.4:c.246+140A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001822.3:n.246+140A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS695377",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000316403.15:c.246+140A="
          },
          "RefSeq": {
            "hgvs": "NM_001831.4:c.246+140A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000315130.10:n.246+140A="
          },
          "RefSeq": {
            "hgvs": "NP_001822.3:n.246+140A="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 501,
          "endIntronDirection": "+",
          "endIntronOffset": 140,
          "referenceAllele": "A",
          "start": 501,
          "startIntronDirection": "+",
          "startIntronOffset": 139
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002095",
      "geneNCBI_id": 1191,
      "geneSymbol": "CLU",
      "hgvs": [
        "NR_038335.2:n.501+140A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS730376"
    }
  ],
  "type": "nucleotide"
}