{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1729674422",
  "communityStandardTitle": [
    "NM_000602.5(SERPINE1):c.*361T="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/11178",
        "rs": 11178
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "T",
          "end": 101137803,
          "referenceAllele": "T",
          "start": 101137802
        }
      ],
      "hgvs": [
        "NC_000007.14:g.101137803T=",
        "CM000669.2:g.101137803T="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000055"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "T",
          "end": 100781084,
          "referenceAllele": "T",
          "start": 100781083
        }
      ],
      "hgvs": [
        "NC_000007.13:g.100781084T=",
        "CM000669.1:g.100781084T="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000031"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "T",
          "end": 100567804,
          "referenceAllele": "T",
          "start": 100567803
        }
      ],
      "hgvs": [
        "NC_000007.12:g.100567804T="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000007"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 15706,
          "referenceAllele": "T",
          "start": 15705
        }
      ],
      "hgvs": [
        "NG_013213.1:g.15706T=",
        "LRG_597:g.15706T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002719"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1712,
          "referenceAllele": "T",
          "start": 1711
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "ENST00000223095.5:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000223095.4:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740605",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000223095.5:c.*361T="
          },
          "RefSeq": {
            "hgvs": "NM_000602.5:c.*361T="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000223095.4:n.*361T="
          },
          "RefSeq": {
            "hgvs": "NP_000593.1:n.*361T="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1727,
          "referenceAllele": "T",
          "start": 1726
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "ENST00000223095.4:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000223095.4:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS248424"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1727,
          "referenceAllele": "T",
          "start": 1726
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_000602.4:c.*361T=",
        "LRG_597t1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_000593.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006655"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1712,
          "referenceAllele": "T",
          "start": 1711
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_000602.5:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_000593.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674905",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000223095.5:c.*361T="
          },
          "RefSeq": {
            "hgvs": "NM_000602.5:c.*361T="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000223095.4:n.*361T="
          },
          "RefSeq": {
            "hgvs": "NP_000593.1:n.*361T="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1491,
          "referenceAllele": "T",
          "start": 1490
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386456.1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373385.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724523"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1576,
          "referenceAllele": "T",
          "start": 1575
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386457.1:c.*372T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373386.1:n.*372T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724524"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1733,
          "referenceAllele": "T",
          "start": 1732
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386458.1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373387.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724525"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1336,
          "endIntronDirection": "-",
          "endIntronOffset": 204,
          "referenceAllele": "T",
          "start": 1336,
          "startIntronDirection": "-",
          "startIntronOffset": 205
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386459.1:c.1195-205T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373388.1:n.1195-205T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724526"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829113601",
      "coordinates": [
        {
          "allele": "T",
          "end": 1327,
          "referenceAllele": "T",
          "start": 1326
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386460.1:c.1185T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373389.1:p.Asp395="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724527"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1229,
          "endIntronDirection": "-",
          "endIntronOffset": 19,
          "referenceAllele": "T",
          "start": 1229,
          "startIntronDirection": "-",
          "startIntronOffset": 20
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386461.1:c.1088-20T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373390.1:n.1088-20T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724528"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1579,
          "referenceAllele": "T",
          "start": 1578
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386462.1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373391.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724529"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1705,
          "referenceAllele": "T",
          "start": 1704
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386463.1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373392.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724530"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1863,
          "referenceAllele": "T",
          "start": 1862
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386464.1:c.*452T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373393.1:n.*452T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724531"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1727,
          "referenceAllele": "T",
          "start": 1726
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386465.1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373394.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724532"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1736,
          "referenceAllele": "T",
          "start": 1735
        }
      ],
      "gene": "http://reg.genome.network/gene/GN008583",
      "geneNCBI_id": 5054,
      "geneSymbol": "SERPINE1",
      "hgvs": [
        "NM_001386466.1:c.*361T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001373395.1:n.*361T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724533"
    }
  ],
  "type": "nucleotide"
}