{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1729174325",
  "communityStandardTitle": [
    "NM_000777.5(CYP3A5):c.432+2T="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/55965422",
        "rs": 55965422
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 99666950,
          "referenceAllele": "A",
          "start": 99666949
        }
      ],
      "hgvs": [
        "NC_000007.14:g.99666950A=",
        "CM000669.2:g.99666950A="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000055"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 99264573,
          "referenceAllele": "A",
          "start": 99264572
        }
      ],
      "hgvs": [
        "NC_000007.13:g.99264573A=",
        "CM000669.1:g.99264573A="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000031"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 99102509,
          "referenceAllele": "A",
          "start": 99102508
        }
      ],
      "hgvs": [
        "NC_000007.12:g.99102509A="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000007"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 18049,
          "referenceAllele": "T",
          "start": 18048
        }
      ],
      "hgvs": [
        "NG_007938.1:g.18049T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000705"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 18049,
          "referenceAllele": "T",
          "start": 18048
        }
      ],
      "hgvs": [
        "NG_007938.2:g.18049T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS733315"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 640,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 640,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000646887.1:c.*117+2T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000496704.1:n.*117+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769117"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 532,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 532,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000222982.8:c.432+2T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000222982.4:n.432+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS248412",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000222982.8:c.432+2T="
          },
          "RefSeq": {
            "hgvs": "NM_000777.5:c.432+2T="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000222982.4:n.432+2T="
          },
          "RefSeq": {
            "hgvs": "NP_000768.1:n.432+2T="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1053,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1053,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000339843.6:c.*831+2T="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343074.2:n.*831+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260959"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1024,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1024,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000461920.5:n.1024+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS306320"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 742,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 742,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000463364.5:n.742+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS307415"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 772,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 772,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000466061.5:n.772+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS309521"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 880,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 880,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000469887.5:n.880+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS312458"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 489,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 489,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000480723.5:n.489+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS320803"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1032,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1032,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "ENST00000481825.5:n.1032+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS321663"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 562,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 562,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NM_000777.4:c.432+2T="
      ],
      "proteinEffect": {
        "hgvs": "NP_000768.1:n.432+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006806"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1062,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1062,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NM_001291829.1:c.93+2T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001278758.1:n.93+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS024329"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 822,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 822,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NM_001291830.1:c.402+2T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001278759.1:n.402+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS024330"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1081,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1081,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NR_033807.2:n.1081+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS049142"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 529,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 529,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XM_006715859.2:c.432+2T="
      ],
      "proteinEffect": {
        "hgvs": "XP_006715922.1:n.432+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS071389"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 679,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 679,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XM_011515843.1:c.93+2T="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514145.1:n.93+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083051"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 654,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 654,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XM_011515844.1:c.93+2T="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514146.1:n.93+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083052"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 678,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 678,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XM_011515845.1:c.-118+2T="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514147.1:n.-118+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083053"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 489,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 489,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XM_011515846.1:c.-118+2T="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514148.1:n.-118+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083054"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 786,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 786,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XM_011515847.1:c.-118+2T="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514149.1:n.-118+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083055"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1464,
          "endIntronDirection": "-",
          "endIntronOffset": 2144,
          "referenceAllele": "A",
          "start": 1464,
          "startIntronDirection": "-",
          "startIntronOffset": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "XM_011515909.1:c.806-2145A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514211.1:n.806-2145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083117"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 665,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 665,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "XR_927383.1:n.665+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS123839"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1466,
          "endIntronDirection": "+",
          "endIntronOffset": 42770,
          "referenceAllele": "A",
          "start": 1466,
          "startIntronDirection": "+",
          "startIntronOffset": 42769
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "XR_927402.1:n.1466+42770A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS123841"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 532,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 532,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NM_000777.5:c.432+2T="
      ],
      "proteinEffect": {
        "hgvs": "NP_000768.1:n.432+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS510850",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000222982.8:c.432+2T="
          },
          "RefSeq": {
            "hgvs": "NM_000777.5:c.432+2T="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000222982.4:n.432+2T="
          },
          "RefSeq": {
            "hgvs": "NP_000768.1:n.432+2T="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1105,
          "endIntronDirection": "-",
          "endIntronOffset": 2144,
          "referenceAllele": "A",
          "start": 1105,
          "startIntronDirection": "-",
          "startIntronOffset": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "NM_001350984.1:c.806-2145A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001337913.1:n.806-2145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS519815"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 920,
          "endIntronDirection": "-",
          "endIntronOffset": 2144,
          "referenceAllele": "A",
          "start": 920,
          "startIntronDirection": "-",
          "startIntronOffset": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "NM_001350985.1:c.806-2145A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001337914.1:n.806-2145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS519816"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1465,
          "endIntronDirection": "-",
          "endIntronOffset": 2144,
          "referenceAllele": "A",
          "start": 1465,
          "startIntronDirection": "-",
          "startIntronOffset": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "XM_011515909.2:c.806-2145A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514211.1:n.806-2145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543930"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1465,
          "endIntronDirection": "+",
          "endIntronOffset": 42770,
          "referenceAllele": "A",
          "start": 1465,
          "startIntronDirection": "+",
          "startIntronOffset": 42769
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "XR_927402.2:n.1465+42770A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS608541"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1032,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1032,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NM_001291829.2:c.93+2T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001278758.1:n.93+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS682873"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 792,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 792,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NM_001291830.2:c.402+2T="
      ],
      "proteinEffect": {
        "hgvs": "NP_001278759.1:n.402+2T="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS682874"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1107,
          "endIntronDirection": "-",
          "endIntronOffset": 2144,
          "referenceAllele": "A",
          "start": 1107,
          "startIntronDirection": "-",
          "startIntronOffset": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "NM_001350984.2:c.806-2145A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001337913.1:n.806-2145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS688606"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 922,
          "endIntronDirection": "-",
          "endIntronOffset": 2144,
          "referenceAllele": "A",
          "start": 922,
          "startIntronDirection": "-",
          "startIntronOffset": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN021961",
      "geneNCBI_id": 221785,
      "geneSymbol": "ZSCAN25",
      "hgvs": [
        "NM_001350985.2:c.806-2145A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001337914.1:n.806-2145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS688607"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1051,
          "endIntronDirection": "+",
          "endIntronOffset": 2,
          "referenceAllele": "T",
          "start": 1051,
          "startIntronDirection": "+",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002638",
      "geneNCBI_id": 1577,
      "geneSymbol": "CYP3A5",
      "hgvs": [
        "NR_033807.3:n.1051+2T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS702171"
    }
  ],
  "type": "nucleotide"
}