{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1720885436",
  "communityStandardTitle": [
    "NM_000601.6(HGF):c.495G= (p.Ser165=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/137853235",
        "rs": 137853235
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "C",
          "end": 81752250,
          "referenceAllele": "C",
          "start": 81752249
        }
      ],
      "hgvs": [
        "NC_000007.14:g.81752250C=",
        "CM000669.2:g.81752250C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000055"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "C",
          "end": 81381566,
          "referenceAllele": "C",
          "start": 81381565
        }
      ],
      "hgvs": [
        "NC_000007.13:g.81381566C=",
        "CM000669.1:g.81381566C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000031"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "C",
          "end": 81219502,
          "referenceAllele": "C",
          "start": 81219501
        }
      ],
      "hgvs": [
        "NC_000007.12:g.81219502C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000007"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 22887,
          "referenceAllele": "G",
          "start": 22886
        }
      ],
      "hgvs": [
        "NG_016274.1:g.22887G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003065"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 22887,
          "referenceAllele": "G",
          "start": 22886
        }
      ],
      "hgvs": [
        "NG_016274.2:g.22887G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS616218"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 571,
          "referenceAllele": "G",
          "start": 570
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000222390.11:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000222390.5:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740570",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000222390.11:c.495G="
          },
          "RefSeq": {
            "hgvs": "NM_000601.6:c.495G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000222390.5:p.Ser165="
          },
          "RefSeq": {
            "hgvs": "NP_000592.3:p.Ser165="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 660,
          "referenceAllele": "G",
          "start": 659
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000423064.7:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000413829.2:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754960"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 572,
          "referenceAllele": "G",
          "start": 571
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000444829.7:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000389854.2:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756018"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 558,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 558,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000453411.6:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000408270.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756428"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 559,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 559,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000457544.7:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391238.2:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756596"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 535,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 535,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000465234.2:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000494355.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756828"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 722,
          "referenceAllele": "G",
          "start": 721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000222390.9:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000222390.5:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS248376"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 629,
          "referenceAllele": "G",
          "start": 628
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000423064.6:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000413829.2:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS287577"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 555,
          "referenceAllele": "G",
          "start": 554
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000444829.6:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000389854.2:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS298003"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 525,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 525,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000453411.5:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000408270.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS302098"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 559,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 559,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000457544.6:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391238.2:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS304002"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 510,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 510,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "ENST00000465234.1:n.511-3G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS308880"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825210052",
      "coordinates": [
        {
          "allele": "G",
          "end": 660,
          "referenceAllele": "G",
          "start": 659
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_000601.4:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000592.3:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006654"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825302933",
      "coordinates": [
        {
          "allele": "G",
          "end": 660,
          "referenceAllele": "G",
          "start": 659
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010931.1:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010931.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008196"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825302933",
      "coordinates": [
        {
          "allele": "G",
          "end": 722,
          "referenceAllele": "G",
          "start": 721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010931.2:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010931.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008197"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 647,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 647,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010932.1:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010932.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008198"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 647,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 647,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010933.1:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010933.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008199"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 709,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 709,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010933.2:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010933.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008200"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825303234",
      "coordinates": [
        {
          "allele": "G",
          "end": 660,
          "referenceAllele": "G",
          "start": 659
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010934.1:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010934.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008201"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825303234",
      "coordinates": [
        {
          "allele": "G",
          "end": 722,
          "referenceAllele": "G",
          "start": 721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010934.2:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010934.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008202"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 685,
          "referenceAllele": "G",
          "start": 684
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "XM_006715956.2:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "XP_006716019.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS071434"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 672,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 672,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "XM_011516115.1:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514417.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083318"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825210052",
      "coordinates": [
        {
          "allele": "G",
          "end": 722,
          "referenceAllele": "G",
          "start": 721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_000601.5:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000592.3:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS510823"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 709,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 709,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010932.2:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010932.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511001"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 672,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 672,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "XM_011516115.2:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011514417.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS544029"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 685,
          "referenceAllele": "G",
          "start": 684
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "XM_017012097.1:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016867586.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS565784"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 672,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 672,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "XM_017012098.1:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016867587.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS565785"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825210052",
      "coordinates": [
        {
          "allele": "G",
          "end": 571,
          "referenceAllele": "G",
          "start": 570
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_000601.6:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000592.3:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662500",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000222390.11:c.495G="
          },
          "RefSeq": {
            "hgvs": "NM_000601.6:c.495G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000222390.5:p.Ser165="
          },
          "RefSeq": {
            "hgvs": "NP_000592.3:p.Ser165="
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825302933",
      "coordinates": [
        {
          "allele": "G",
          "end": 571,
          "referenceAllele": "G",
          "start": 570
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010931.3:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010931.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS675382"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 558,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 558,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010932.3:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010932.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS675383"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 558,
          "endIntronDirection": "-",
          "endIntronOffset": 2,
          "referenceAllele": "G",
          "start": 558,
          "startIntronDirection": "-",
          "startIntronOffset": 3
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010933.3:c.483-3G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010933.1:n.483-3G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS675384"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825303234",
      "coordinates": [
        {
          "allele": "G",
          "end": 571,
          "referenceAllele": "G",
          "start": 570
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004893",
      "geneNCBI_id": 3082,
      "geneSymbol": "HGF",
      "hgvs": [
        "NM_001010934.3:c.495G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001010934.1:p.Ser165="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS675385"
    }
  ],
  "type": "nucleotide"
}