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      },
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    },
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        {
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          "end": 1449,
          "referenceAllele": "",
          "start": 1449
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      ],
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      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001356320.1:p.[Ala166_Asp167del;Gln169_Lys174del;Gly176_Ala188delinsGln;Lys192_Val195delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691616"
    },
    {
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          "referenceAllele": "",
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
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      "geneSymbol": "MECP2",
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      ],
      "proteinEffect": {
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      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691617"
    },
    {
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        {
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      ],
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      "geneSymbol": "MECP2",
      "hgvs": [
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      ],
      "proteinEffect": {
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        "hgvsWellDefined": "NP_001356322.1:p.[Ala166_Asp167del;Gln169_Lys174del;Gly176_Ala188delinsGln;Lys192_Val195delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691618"
    },
    {
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          "referenceAllele": "",
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      ],
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      "geneSymbol": "MECP2",
      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001356323.1:p.[Ala166_Asp167del;Gln169_Lys174del;Gly176_Ala188delinsGln;Lys192_Val195delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691619"
    },
    {
      "coordinates": [
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          "referenceAllele": "",
          "start": 905
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
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      "geneSymbol": "MECP2",
      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001356323.1:p.[Ala166_Asp167del;Gln169_Lys174del;Gly176_Ala188delinsGln;Lys192_Val195delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721143"
    },
    {
      "coordinates": [
        {
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          "end": 989,
          "referenceAllele": "",
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
      "geneNCBI_id": 4204,
      "geneSymbol": "MECP2",
      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001373066.1:p.[Ala36_Asp37del;Gln39_Lys44del;Gly46_Ala58delinsGln;Lys62_Val65delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724415"
    },
    {
      "coordinates": [
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          "referenceAllele": "",
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
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      "geneSymbol": "MECP2",
      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001373067.1:p.[Ala36_Asp37del;Gln39_Lys44del;Gly46_Ala58delinsGln;Lys62_Val65delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724416"
    },
    {
      "coordinates": [
        {
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          "referenceAllele": "",
          "start": 753
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
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      "hgvs": [
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      ],
      "proteinEffect": {
        "hgvs": "NP_001373068.1:p.Ala36ProfsTer8",
        "hgvsWellDefined": "NP_001373068.1:p.[Ala36_Asp37del;Gln39_Lys44del;Gly46_Ala58delinsGln;Lys62_Val65delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724417"
    },
    {
      "coordinates": [
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          "referenceAllele": "",
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
      "geneNCBI_id": 4204,
      "geneSymbol": "MECP2",
      "hgvs": [
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      ],
      "proteinEffect": {
        "hgvs": "NP_004983.1:p.Ala259ProfsTer8",
        "hgvsWellDefined": "NP_004983.1:p.[Ala259_Asp260del;Gln262_Lys267del;Gly269_Ala281delinsGln;Lys285_Val288delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS727571",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000303391.11:c.750_774dup"
          },
          "RefSeq": {
            "hgvs": "NM_004992.4:c.750_774dup"
          }
        },
        "protein": {
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          },
          "RefSeq": {
            "hgvs": "NP_004983.1:p.Ala259ProfsTer8"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}