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        "hgvs": "NP_277043.1:p.Arg446GlyfsTer?",
        "hgvsWellDefined": "NP_277043.1:p.[Arg446del;Ala449_Val451delinsArgProTrp;Ala453delinsArgArgTrpPro;Ala455_Lys458delinsArgArgProValCysTrp;Cys460_Leu462delinsSerGluSerSer;Gln464delinsArgLysArgArgGluAspAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS526402"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 539,
          "referenceAllele": "C",
          "start": 538
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "XM_024446707.1:c.199del"
      ],
      "proteinEffect": {
        "hgvs": "XP_024302475.1:p.Arg67GlyfsTer?",
        "hgvsWellDefined": "XP_024302475.1:p.[Arg67del;Ala70_Val72delinsArgProTrp;Ala74delinsArgArgTrpPro;Ala76_Lys79delinsArgArgProValCysTrp;Cys81_Leu83delinsSerGluSerSer;Gln85delinsArgLysArgArgGluAspAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS580363"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1825,
          "referenceAllele": "C",
          "start": 1824
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_000162.5:c.1339del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000153.1:p.Arg447GlyfsTer?",
        "hgvsWellDefined": "NP_000153.1:p.[Arg447del;Ala450_Val452delinsArgProTrp;Ala454delinsArgArgTrpPro;Ala456_Lys459delinsArgArgProValCysTrp;Cys461_Leu463delinsSerGluSerSer;Gln465delinsArgLysArgArgGluAspAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662335",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000403799.8:c.1339del"
          },
          "RefSeq": {
            "hgvs": "NM_000162.5:c.1339del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000384247.3:p.Arg447GlyfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000153.1:p.Arg447GlyfsTer?"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1504,
          "referenceAllele": "C",
          "start": 1503
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_033507.3:c.1342del"
      ],
      "proteinEffect": {
        "hgvs": "NP_277042.1:p.Arg448GlyfsTer?",
        "hgvsWellDefined": "NP_277042.1:p.[Arg448del;Ala451_Val453delinsArgProTrp;Ala455delinsArgArgTrpPro;Ala457_Lys460delinsArgArgProValCysTrp;Cys462_Leu464delinsSerGluSerSer;Gln466delinsArgLysArgArgGluAspAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699364"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1628,
          "referenceAllele": "C",
          "start": 1627
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_033508.3:c.1336del"
      ],
      "proteinEffect": {
        "hgvs": "NP_277043.1:p.Arg446GlyfsTer?",
        "hgvsWellDefined": "NP_277043.1:p.[Arg446del;Ala449_Val451delinsArgProTrp;Ala453delinsArgArgTrpPro;Ala455_Lys458delinsArgArgProValCysTrp;Cys460_Leu462delinsSerGluSerSer;Gln464delinsArgLysArgArgGluAspAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699365"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 391,
          "referenceAllele": "C",
          "start": 390
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_001354803.2:c.373del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341732.1:p.Arg125GlyfsTer?",
        "hgvsWellDefined": "NP_001341732.1:p.[Arg125del;Ala128_Val130delinsArgProTrp;Ala132delinsArgArgTrpPro;Ala134_Lys137delinsArgArgProValCysTrp;Cys139_Leu141delinsSerGluSerSer;Gln143delinsArgLysArgArgGluAspAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720578"
    }
  ],
  "type": "nucleotide"
}