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      "proteinEffect": {
        "hgvs": "NP_115781.1:p.Cys194Ter",
        "hgvsWellDefined": "NP_115781.1:p.Cys194_Leu344delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGlyThrSerGlySerLeuCysGlySerAlaAlaLeuProLeuPheGlnGluAspLeuGlnLeuLeuIleGluAlaPheLeuTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS039057"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1538,
          "referenceAllele": "T",
          "start": 1537
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NR_046020.1:n.1538T>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS051455"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826381736",
      "coordinates": [
        {
          "allele": "A",
          "end": 744,
          "referenceAllele": "T",
          "start": 743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NM_001256317.2:c.582T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001243246.1:p.Cys194Ter",
        "hgvsWellDefined": "NP_001243246.1:p.Cys194_Thr453delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGluMetIleGlnProValCysLeuProAsnSerGluGluAsnPheProAspGlyLysValCysTrpThrSerGlyTrpGlyAlaThrGluAspGlyGlyAspAlaSerProValLeuAsnHisAlaAlaValProLeuIleSerAsnLysIleCysAsnHisArgAspValTyrGlyGlyIleIleSerProSerMetLeuCysAlaGlyTyrLeuThrGlyGlyValAspSerCysGlnGlyAspSerGlyGlyProLeuValCysGlnGluArgArgLeuTrpLysLeuValGlyAlaThrSerPheGlyIleGlyCysAlaGluValAsnLysProGlyValTyrThrArgValThrSerPheLeuAspTrpIleHisGluGlnMetGluArgAspLeuLysThrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS680535"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2830021270",
      "coordinates": [
        {
          "allele": "A",
          "end": 744,
          "referenceAllele": "T",
          "start": 743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NM_024022.3:c.582T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_076927.1:p.Cys194Ter",
        "hgvsWellDefined": "NP_076927.1:p.Cys194_Thr454delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGluMetIleGlnProValCysLeuProAsnSerGluGluAsnPheProAspGlyLysValCysTrpThrSerGlyTrpGlyAlaThrGluAspGlyAlaGlyAspAlaSerProValLeuAsnHisAlaAlaValProLeuIleSerAsnLysIleCysAsnHisArgAspValTyrGlyGlyIleIleSerProSerMetLeuCysAlaGlyTyrLeuThrGlyGlyValAspSerCysGlnGlyAspSerGlyGlyProLeuValCysGlnGluArgArgLeuTrpLysLeuValGlyAlaThrSerPheGlyIleGlyCysAlaGluValAsnLysProGlyValTyrThrArgValThrSerPheLeuAspTrpIleHisGluGlnMetGluArgAspLeuLysThrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS698644"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645434905",
      "coordinates": [
        {
          "allele": "A",
          "end": 744,
          "referenceAllele": "T",
          "start": 743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NM_032405.2:c.582T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_115781.1:p.Cys194Ter",
        "hgvsWellDefined": "NP_115781.1:p.Cys194_Leu344delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGlyThrSerGlySerLeuCysGlySerAlaAlaLeuProLeuPheGlnGluAspLeuGlnLeuLeuIleGluAlaPheLeuTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826381736",
      "coordinates": [
        {
          "allele": "A",
          "end": 744,
          "referenceAllele": "T",
          "start": 743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NM_001256317.3:c.582T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001243246.1:p.Cys194Ter",
        "hgvsWellDefined": "NP_001243246.1:p.Cys194_Thr453delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGluMetIleGlnProValCysLeuProAsnSerGluGluAsnPheProAspGlyLysValCysTrpThrSerGlyTrpGlyAlaThrGluAspGlyGlyAspAlaSerProValLeuAsnHisAlaAlaValProLeuIleSerAsnLysIleCysAsnHisArgAspValTyrGlyGlyIleIleSerProSerMetLeuCysAlaGlyTyrLeuThrGlyGlyValAspSerCysGlnGlyAspSerGlyGlyProLeuValCysGlnGluArgArgLeuTrpLysLeuValGlyAlaThrSerPheGlyIleGlyCysAlaGluValAsnLysProGlyValTyrThrArgValThrSerPheLeuAspTrpIleHisGluGlnMetGluArgAspLeuLysThrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714742",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000644384.2:c.582T>A"
          },
          "RefSeq": {
            "hgvs": "NM_001256317.3:c.582T>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000494414.1:p.Cys194Ter"
          },
          "RefSeq": {
            "hgvs": "NP_001243246.1:p.Cys194Ter"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2830021270",
      "coordinates": [
        {
          "allele": "A",
          "end": 744,
          "referenceAllele": "T",
          "start": 743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NM_024022.4:c.582T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_076927.1:p.Cys194Ter",
        "hgvsWellDefined": "NP_076927.1:p.Cys194_Thr454delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGluMetIleGlnProValCysLeuProAsnSerGluGluAsnPheProAspGlyLysValCysTrpThrSerGlyTrpGlyAlaThrGluAspGlyAlaGlyAspAlaSerProValLeuAsnHisAlaAlaValProLeuIleSerAsnLysIleCysAsnHisArgAspValTyrGlyGlyIleIleSerProSerMetLeuCysAlaGlyTyrLeuThrGlyGlyValAspSerCysGlnGlyAspSerGlyGlyProLeuValCysGlnGluArgArgLeuTrpLysLeuValGlyAlaThrSerPheGlyIleGlyCysAlaGluValAsnLysProGlyValTyrThrArgValThrSerPheLeuAspTrpIleHisGluGlnMetGluArgAspLeuLysThrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS728624"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916067313",
      "coordinates": [
        {
          "allele": "A",
          "end": 481,
          "referenceAllele": "T",
          "start": 480
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011877",
      "geneNCBI_id": 64699,
      "geneSymbol": "TMPRSS3",
      "hgvs": [
        "NM_032404.3:c.201T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_115780.1:p.Cys67Ter",
        "hgvsWellDefined": "NP_115780.1:p.Cys67_Thr327delinsAlaSerGlyHisValValThrLeuGlnCysThrAlaCysGlyHisArgArgGlyTyrSerSerArgIleValGlyGlyAsnMetSerLeuLeuSerGlnTrpProTrpGlnAlaSerLeuGlnPheGlnGlyTyrHisLeuCysGlyGlySerValIleThrProLeuTrpIleIleThrAlaAlaHisCysValTyrAspLeuTyrLeuProLysSerTrpThrIleGlnValGlyLeuValSerLeuLeuAspAsnProAlaProSerHisLeuValGluLysIleValTyrHisSerLysTyrLysProLysArgLeuGlyAsnAspIleAlaLeuMetLysLeuAlaGlyProLeuThrPheAsnGluMetIleGlnProValCysLeuProAsnSerGluGluAsnPheProAspGlyLysValCysTrpThrSerGlyTrpGlyAlaThrGluAspGlyAlaGlyAspAlaSerProValLeuAsnHisAlaAlaValProLeuIleSerAsnLysIleCysAsnHisArgAspValTyrGlyGlyIleIleSerProSerMetLeuCysAlaGlyTyrLeuThrGlyGlyValAspSerCysGlnGlyAspSerGlyGlyProLeuValCysGlnGluArgArgLeuTrpLysLeuValGlyAlaThrSerPheGlyIleGlyCysAlaGluValAsnLysProGlyValTyrThrArgValThrSerPheLeuAspTrpIleHisGluGlnMetGluArgAspLeuLysThrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS728830"
    }
  ],
  "type": "nucleotide"
}