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        "hgvsWellDefined": "NP_277043.1:p.[Ala448_Leu450delinsArgProTrpSerArgArgTrpPro;Ser452_Ala453delinsArgArgPro;Val454_Ala455insCysTrp;Cys456_Lys457delinsSerGluSerSerGlyArg;Ala459_Gln464delinsArgArgGluAspAlaThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS526402"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 544,
          "referenceAllele": "C",
          "start": 543
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "XM_024446707.1:c.204del"
      ],
      "proteinEffect": {
        "hgvs": "XP_024302475.1:p.Ala69ArgfsTer?",
        "hgvsWellDefined": "XP_024302475.1:p.[Ala69_Leu71delinsArgProTrpSerArgArgTrpPro;Ser73_Ala74delinsArgArgPro;Val75_Ala76insCysTrp;Cys77_Lys78delinsSerGluSerSerGlyArg;Ala80_Gln85delinsArgArgGluAspAlaThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS580363"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1830,
          "referenceAllele": "C",
          "start": 1829
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_000162.5:c.1344del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000153.1:p.Ala449ArgfsTer?",
        "hgvsWellDefined": "NP_000153.1:p.[Ala449_Leu451delinsArgProTrpSerArgArgTrpPro;Ser453_Ala454delinsArgArgPro;Val455_Ala456insCysTrp;Cys457_Lys458delinsSerGluSerSerGlyArg;Ala460_Gln465delinsArgArgGluAspAlaThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662335",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000403799.8:c.1344del"
          },
          "RefSeq": {
            "hgvs": "NM_000162.5:c.1344del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000384247.3:p.Ala449ArgfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000153.1:p.Ala449ArgfsTer?"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1509,
          "referenceAllele": "C",
          "start": 1508
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_033507.3:c.1347del"
      ],
      "proteinEffect": {
        "hgvs": "NP_277042.1:p.Ala450ArgfsTer?",
        "hgvsWellDefined": "NP_277042.1:p.[Ala450_Leu452delinsArgProTrpSerArgArgTrpPro;Ser454_Ala455delinsArgArgPro;Val456_Ala457insCysTrp;Cys458_Lys459delinsSerGluSerSerGlyArg;Ala461_Gln466delinsArgArgGluAspAlaThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699364"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1633,
          "referenceAllele": "C",
          "start": 1632
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_033508.3:c.1341del"
      ],
      "proteinEffect": {
        "hgvs": "NP_277043.1:p.Ala448ArgfsTer?",
        "hgvsWellDefined": "NP_277043.1:p.[Ala448_Leu450delinsArgProTrpSerArgArgTrpPro;Ser452_Ala453delinsArgArgPro;Val454_Ala455insCysTrp;Cys456_Lys457delinsSerGluSerSerGlyArg;Ala459_Gln464delinsArgArgGluAspAlaThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699365"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 396,
          "referenceAllele": "C",
          "start": 395
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004195",
      "geneNCBI_id": 2645,
      "geneSymbol": "GCK",
      "hgvs": [
        "NM_001354803.2:c.378del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341732.1:p.Ala127ArgfsTer?",
        "hgvsWellDefined": "NP_001341732.1:p.[Ala127_Leu129delinsArgProTrpSerArgArgTrpPro;Ser131_Ala132delinsArgArgPro;Val133_Ala134insCysTrp;Cys135_Lys136delinsSerGluSerSerGlyArg;Ala138_Gln143delinsArgArgGluAspAlaThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720578"
    }
  ],
  "type": "nucleotide"
}