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      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "GA",
          "end": 889,
          "referenceAllele": "",
          "start": 889
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.563_564dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Tyr189AspfsTer9",
        "hgvsWellDefined": "NP_001291646.4:p.[Tyr189_Glu191del;Gly193_Leu196delinsIleLysArgMet;Leu198Ser;Ile201_Tyr219del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
        {
          "allele": "GA",
          "end": 889,
          "referenceAllele": "",
          "start": 889
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.-662_-661dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:n.-662_-661dup"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
        {
          "allele": "GA",
          "end": 890,
          "referenceAllele": "",
          "start": 890
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.44_45dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Tyr16AspfsTer9",
        "hgvsWellDefined": "NP_000305.3:p.[Tyr16_Glu18del;Gly20_Leu23delinsIleLysArgMet;Leu25Ser;Ile28_Tyr46del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.44_45dup"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.44_45dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Tyr16AspfsTer9"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Tyr16AspfsTer9"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}