{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA16603024",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.730G>C (p.Gly244Arg)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=44221",
        "active": true,
        "id": "COSM44221"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=673602",
        "active": true,
        "id": "COSM673602"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=673603",
        "active": true,
        "id": "COSM673603"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=673604",
        "active": true,
        "id": "COSM673604"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3970348",
        "active": true,
        "id": "COSM3970348"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3970349",
        "active": true,
        "id": "COSM3970349"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=363481[alleleid]",
        "alleleId": 363481,
        "preferredName": "NM_000546.6(TP53):c.730G>C (p.Gly244Arg)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/376602",
        "RCV": [
          "RCV000419267",
          "RCV000420351",
          "RCV000418001",
          "RCV000424520",
          "RCV000425133",
          "RCV000425485",
          "RCV000430145",
          "RCV000431028",
          "RCV000432729",
          "RCV000435229",
          "RCV000437599",
          "RCV000438254",
          "RCV000443153"
        ],
        "variationId": 376602
      },
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/3634428",
        "RCV": [
          "RCV005109051"
        ],
        "variationId": 3634428
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7577551C>G?assembly=hg19",
        "id": "chr17:g.7577551C>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7674233C>G?assembly=hg38",
        "id": "chr17:g.7674233C>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057519989",
        "rs": 1057519989
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/17-7674233-C-G?dataset=gnomad_r4",
        "id": "17-7674233-C-G",
        "variant": "17:7674233 C / G"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "G",
          "end": 7674233,
          "referenceAllele": "C",
          "start": 7674232
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7674233C>G",
        "CM000679.2:g.7674233C>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "G",
          "end": 7577551,
          "referenceAllele": "C",
          "start": 7577550
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7577551C>G",
        "CM000679.1:g.7577551C>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "G",
          "end": 7518276,
          "referenceAllele": "C",
          "start": 7518275
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7518276C>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 18318,
          "referenceAllele": "G",
          "start": 18317
        }
      ],
      "hgvs": [
        "NG_017013.2:g.18318G>C",
        "LRG_321:g.18318G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 912,
          "referenceAllele": "G",
          "start": 911
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000426252.2:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1012,
          "referenceAllele": "G",
          "start": 1011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000424104.2:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 466,
          "referenceAllele": "G",
          "start": 465
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Gly112Arg",
        "hgvsWellDefined": "ENSP00000425104.2:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 530,
          "referenceAllele": "G",
          "start": 529
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.451G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Gly151Arg",
        "hgvsWellDefined": "ENSP00000423862.2:p.Gly151Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 848,
          "referenceAllele": "G",
          "start": 847
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.709G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Gly237Arg",
        "hgvsWellDefined": "ENSP00000473895.2:p.Gly237Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000269305.4:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.730G>C"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.730G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Gly244Arg"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Gly244Arg"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 920,
          "referenceAllele": "G",
          "start": 919
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000269305.4:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 730,
          "referenceAllele": "G",
          "start": 729
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000352610.4:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 730,
          "referenceAllele": "G",
          "start": 729
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000410739.2:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 863,
          "referenceAllele": "G",
          "start": 862
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000391127.2:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 866,
          "referenceAllele": "G",
          "start": 865
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000391478.2:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 863,
          "referenceAllele": "G",
          "start": 862
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000398846.2:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:p.Gly112Arg",
        "hgvsWellDefined": "ENSP00000484409.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Gly112Arg",
        "hgvsWellDefined": "ENSP00000481179.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 466,
          "referenceAllele": "G",
          "start": 465
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.5:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.1:p.Gly112Arg",
        "hgvsWellDefined": "ENSP00000425104.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247215"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:p.Gly112Arg",
        "hgvsWellDefined": "ENSP00000478499.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 530,
          "referenceAllele": "G",
          "start": 529
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.5:c.451G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.1:p.Gly151Arg",
        "hgvsWellDefined": "ENSP00000423862.1:p.Gly151Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247340"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 980,
          "referenceAllele": "G",
          "start": 979
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Gly205Arg",
        "hgvsWellDefined": "ENSP00000478219.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 863,
          "referenceAllele": "G",
          "start": 862
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:p.Gly205Arg",
        "hgvsWellDefined": "ENSP00000480868.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:p.Gly85Arg",
        "hgvsWellDefined": "ENSP00000477531.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 697,
          "referenceAllele": "G",
          "start": 696
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.697G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Gly233Arg",
        "hgvsWellDefined": "ENSP00000482903.1:p.Gly233Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:p.Gly244Arg",
        "hgvsWellDefined": "ENSP00000482258.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:p.Gly85Arg",
        "hgvsWellDefined": "ENSP00000481401.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:p.Gly85Arg",
        "hgvsWellDefined": "ENSP00000484375.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 866,
          "referenceAllele": "G",
          "start": 865
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Gly205Arg",
        "hgvsWellDefined": "ENSP00000482537.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 920,
          "referenceAllele": "G",
          "start": 919
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Gly205Arg",
        "hgvsWellDefined": "ENSP00000481638.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 863,
          "referenceAllele": "G",
          "start": 862
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:p.Gly205Arg",
        "hgvsWellDefined": "ENSP00000482222.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 873,
          "referenceAllele": "G",
          "start": 872
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Gly205Arg",
        "hgvsWellDefined": "ENSP00000488924.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579935192",
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.730G>C",
        "LRG_321t1:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Gly244Arg",
        "hgvsWellDefined": "NP_000537.3:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825601003",
      "coordinates": [
        {
          "allele": "C",
          "end": 929,
          "referenceAllele": "G",
          "start": 928
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.730G>C",
        "LRG_321t2:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Gly244Arg",
        "hgvsWellDefined": "NP_001119584.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825605088",
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.730G>C",
        "LRG_321t4:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Gly244Arg",
        "hgvsWellDefined": "NP_001119585.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645435703",
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.730G>C",
        "LRG_321t3:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Gly244Arg",
        "hgvsWellDefined": "NP_001119586.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825610830",
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.334G>C",
        "LRG_321t5:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Gly112Arg",
        "hgvsWellDefined": "NP_001119587.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825613640",
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.334G>C",
        "LRG_321t6:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Gly112Arg",
        "hgvsWellDefined": "NP_001119588.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825615624",
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.334G>C",
        "LRG_321t7:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Gly112Arg",
        "hgvsWellDefined": "NP_001119589.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825618412",
      "coordinates": [
        {
          "allele": "C",
          "end": 1049,
          "referenceAllele": "G",
          "start": 1048
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.613G>C",
        "LRG_321t8:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001119590.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559923",
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263624.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561386",
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263625.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562295",
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263626.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563418",
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263627.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006346",
      "coordinates": [
        {
          "allele": "C",
          "end": 612,
          "referenceAllele": "G",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263628.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565770",
      "coordinates": [
        {
          "allele": "C",
          "end": 932,
          "referenceAllele": "G",
          "start": 931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263689.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567287",
      "coordinates": [
        {
          "allele": "C",
          "end": 929,
          "referenceAllele": "G",
          "start": 928
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263690.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559923",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263624.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561386",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263625.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562295",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263626.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563418",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263627.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006346",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263628.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565770",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263689.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567287",
      "coordinates": [
        {
          "allele": "C",
          "end": 869,
          "referenceAllele": "G",
          "start": 868
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263690.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579935192",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Gly244Arg",
        "hgvsWellDefined": "NP_000537.3:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.730G>C"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.730G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Gly244Arg"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Gly244Arg"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825601003",
      "coordinates": [
        {
          "allele": "C",
          "end": 869,
          "referenceAllele": "G",
          "start": 868
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Gly244Arg",
        "hgvsWellDefined": "NP_001119584.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825605088",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Gly244Arg",
        "hgvsWellDefined": "NP_001119585.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645435703",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.730G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Gly244Arg",
        "hgvsWellDefined": "NP_001119586.1:p.Gly244Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825610830",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Gly112Arg",
        "hgvsWellDefined": "NP_001119587.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825613640",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Gly112Arg",
        "hgvsWellDefined": "NP_001119588.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825615624",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.334G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Gly112Arg",
        "hgvsWellDefined": "NP_001119589.1:p.Gly112Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825618412",
      "coordinates": [
        {
          "allele": "C",
          "end": 989,
          "referenceAllele": "G",
          "start": 988
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001119590.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559923",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263624.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561386",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263625.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562295",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263626.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563418",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263627.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006346",
      "coordinates": [
        {
          "allele": "C",
          "end": 363,
          "referenceAllele": "G",
          "start": 362
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.253G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Gly85Arg",
        "hgvsWellDefined": "NP_001263628.1:p.Gly85Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565770",
      "coordinates": [
        {
          "allele": "C",
          "end": 872,
          "referenceAllele": "G",
          "start": 871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263689.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567287",
      "coordinates": [
        {
          "allele": "C",
          "end": 869,
          "referenceAllele": "G",
          "start": 868
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.613G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Gly205Arg",
        "hgvsWellDefined": "NP_001263690.1:p.Gly205Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}