{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA16602989",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.403T>G (p.Cys135Gly)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=44829",
        "active": true,
        "id": "COSM44829"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1645410",
        "active": true,
        "id": "COSM1645410"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1645411",
        "active": true,
        "id": "COSM1645411"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1645412",
        "active": true,
        "id": "COSM1645412"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1645413",
        "active": true,
        "id": "COSM1645413"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1645414",
        "active": true,
        "id": "COSM1645414"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3937614",
        "active": true,
        "id": "COSM3937614"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=363442[alleleid]",
        "alleleId": 363442,
        "preferredName": "NM_000546.6(TP53):c.403T>G (p.Cys135Gly)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/376563",
        "RCV": [
          "RCV000418158",
          "RCV000420954",
          "RCV000422074",
          "RCV000423071",
          "RCV000429525",
          "RCV000428411",
          "RCV000432330",
          "RCV000433361",
          "RCV000437581",
          "RCV000438642",
          "RCV000439732",
          "RCV000445231",
          "RCV000444598",
          "RCV000570655",
          "RCV000785515",
          "RCV000991142",
          "RCV004022201"
        ],
        "variationId": 376563
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7578527A>C?assembly=hg19",
        "id": "chr17:g.7578527A>C"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7675209A>C?assembly=hg38",
        "id": "chr17:g.7675209A>C"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057519975",
        "rs": 1057519975
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "C",
          "end": 7675209,
          "referenceAllele": "A",
          "start": 7675208
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7675209A>C",
        "CM000679.2:g.7675209A>C"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "C",
          "end": 7578527,
          "referenceAllele": "A",
          "start": 7578526
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7578527A>C",
        "CM000679.1:g.7578527A>C"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "C",
          "end": 7519252,
          "referenceAllele": "A",
          "start": 7519251
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7519252A>C"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 17342,
          "referenceAllele": "T",
          "start": 17341
        }
      ],
      "hgvs": [
        "NG_017013.2:g.17342T>G",
        "LRG_321:g.17342T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 585,
          "referenceAllele": "T",
          "start": 584
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000426252.2:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 685,
          "referenceAllele": "T",
          "start": 684
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000424104.2:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 139,
          "referenceAllele": "T",
          "start": 138
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Cys3Gly",
        "hgvsWellDefined": "ENSP00000425104.2:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 203,
          "referenceAllele": "T",
          "start": 202
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.124T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Cys42Gly",
        "hgvsWellDefined": "ENSP00000423862.2:p.Cys42Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 521,
          "referenceAllele": "T",
          "start": 520
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.382T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Cys128Gly",
        "hgvsWellDefined": "ENSP00000473895.2:p.Cys128Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000269305.4:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.403T>G"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.403T>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Cys135Gly"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Cys135Gly"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 593,
          "referenceAllele": "T",
          "start": 592
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000269305.4:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 403,
          "referenceAllele": "T",
          "start": 402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000352610.4:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 403,
          "referenceAllele": "T",
          "start": 402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000410739.2:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 536,
          "referenceAllele": "T",
          "start": 535
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000391127.2:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 539,
          "referenceAllele": "T",
          "start": 538
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000391478.2:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 536,
          "referenceAllele": "T",
          "start": 535
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000398846.2:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:p.Cys3Gly",
        "hgvsWellDefined": "ENSP00000484409.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Cys3Gly",
        "hgvsWellDefined": "ENSP00000481179.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 659,
          "referenceAllele": "T",
          "start": 658
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000505014.5:n.659T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS336915"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 541,
          "referenceAllele": "T",
          "start": 540
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.5:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.1:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000424104.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247237"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 139,
          "referenceAllele": "T",
          "start": 138
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.5:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.1:p.Cys3Gly",
        "hgvsWellDefined": "ENSP00000425104.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247215"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:p.Cys3Gly",
        "hgvsWellDefined": "ENSP00000478499.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 203,
          "referenceAllele": "T",
          "start": 202
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.5:c.124T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.1:p.Cys42Gly",
        "hgvsWellDefined": "ENSP00000423862.1:p.Cys42Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247340"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 521,
          "referenceAllele": "T",
          "start": 520
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.5:c.382T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.1:p.Cys128Gly",
        "hgvsWellDefined": "ENSP00000473895.1:p.Cys128Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247300"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 653,
          "referenceAllele": "T",
          "start": 652
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Cys96Gly",
        "hgvsWellDefined": "ENSP00000478219.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 536,
          "referenceAllele": "T",
          "start": 535
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:p.Cys96Gly",
        "hgvsWellDefined": "ENSP00000480868.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 370,
          "referenceAllele": "T",
          "start": 369
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.370T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Cys124Gly",
        "hgvsWellDefined": "ENSP00000482903.1:p.Cys124Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:p.Cys135Gly",
        "hgvsWellDefined": "ENSP00000482258.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 539,
          "referenceAllele": "T",
          "start": 538
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Cys96Gly",
        "hgvsWellDefined": "ENSP00000482537.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 593,
          "referenceAllele": "T",
          "start": 592
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Cys96Gly",
        "hgvsWellDefined": "ENSP00000481638.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 536,
          "referenceAllele": "T",
          "start": 535
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:p.Cys96Gly",
        "hgvsWellDefined": "ENSP00000482222.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 546,
          "referenceAllele": "T",
          "start": 545
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Cys96Gly",
        "hgvsWellDefined": "ENSP00000488924.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579936491",
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.403T>G",
        "LRG_321t1:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Cys135Gly",
        "hgvsWellDefined": "NP_000537.3:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825599521",
      "coordinates": [
        {
          "allele": "G",
          "end": 602,
          "referenceAllele": "T",
          "start": 601
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.403T>G",
        "LRG_321t2:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Cys135Gly",
        "hgvsWellDefined": "NP_001119584.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825603548",
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.403T>G",
        "LRG_321t4:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Cys135Gly",
        "hgvsWellDefined": "NP_001119585.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825607057",
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.403T>G",
        "LRG_321t3:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Cys135Gly",
        "hgvsWellDefined": "NP_001119586.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825609465",
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.7T>G",
        "LRG_321t5:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Cys3Gly",
        "hgvsWellDefined": "NP_001119587.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825612316",
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.7T>G",
        "LRG_321t6:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Cys3Gly",
        "hgvsWellDefined": "NP_001119588.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825614612",
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.7T>G",
        "LRG_321t7:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Cys3Gly",
        "hgvsWellDefined": "NP_001119589.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645438192",
      "coordinates": [
        {
          "allele": "G",
          "end": 722,
          "referenceAllele": "T",
          "start": 721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.286T>G",
        "LRG_321t8:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001119590.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559309",
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263624.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826560770",
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263625.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 285,
          "referenceAllele": "T",
          "start": 284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565163",
      "coordinates": [
        {
          "allele": "G",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263689.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006755",
      "coordinates": [
        {
          "allele": "G",
          "end": 602,
          "referenceAllele": "T",
          "start": 601
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263690.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559309",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263624.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826560770",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263625.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565163",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263689.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006755",
      "coordinates": [
        {
          "allele": "G",
          "end": 542,
          "referenceAllele": "T",
          "start": 541
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263690.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579936491",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Cys135Gly",
        "hgvsWellDefined": "NP_000537.3:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.403T>G"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.403T>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Cys135Gly"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Cys135Gly"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825599521",
      "coordinates": [
        {
          "allele": "G",
          "end": 542,
          "referenceAllele": "T",
          "start": 541
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Cys135Gly",
        "hgvsWellDefined": "NP_001119584.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825603548",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Cys135Gly",
        "hgvsWellDefined": "NP_001119585.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825607057",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.403T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Cys135Gly",
        "hgvsWellDefined": "NP_001119586.1:p.Cys135Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825609465",
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Cys3Gly",
        "hgvsWellDefined": "NP_001119587.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825612316",
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Cys3Gly",
        "hgvsWellDefined": "NP_001119588.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825614612",
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.7T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Cys3Gly",
        "hgvsWellDefined": "NP_001119589.1:p.Cys3Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645438192",
      "coordinates": [
        {
          "allele": "G",
          "end": 662,
          "referenceAllele": "T",
          "start": 661
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001119590.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559309",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263624.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826560770",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263625.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 36,
          "referenceAllele": "T",
          "start": 35
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.-75T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.-75T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565163",
      "coordinates": [
        {
          "allele": "G",
          "end": 545,
          "referenceAllele": "T",
          "start": 544
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263689.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006755",
      "coordinates": [
        {
          "allele": "G",
          "end": 542,
          "referenceAllele": "T",
          "start": 541
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.286T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Cys96Gly",
        "hgvsWellDefined": "NP_001263690.1:p.Cys96Gly"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}