{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA16602854",
  "communityStandardTitle": [
    "NM_001349798.2(FBXW7):c.1394G>T (p.Arg465Leu)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=33762",
        "active": true,
        "id": "COSM33762"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=673923",
        "active": true,
        "id": "COSM673923"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=673924",
        "active": true,
        "id": "COSM673924"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=673925",
        "active": true,
        "id": "COSM673925"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=4775085",
        "active": true,
        "id": "COSM4775085"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=363296[alleleid]",
        "alleleId": 363296,
        "preferredName": "NM_001349798.2(FBXW7):c.1394G>T (p.Arg465Leu)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/376417",
        "RCV": [
          "RCV000419727",
          "RCV000421731",
          "RCV000422964",
          "RCV000423635",
          "RCV000425901",
          "RCV000431029",
          "RCV000430408",
          "RCV000431539",
          "RCV000434382",
          "RCV000436100",
          "RCV000440224",
          "RCV000441781",
          "RCV000443518",
          "RCV000443662"
        ],
        "variationId": 376417
      },
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/4530542",
        "RCV": [
          "RCV006255036"
        ],
        "variationId": 4530542
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr4:g.153249384C>A?assembly=hg19",
        "id": "chr4:g.153249384C>A"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr4:g.152328232C>A?assembly=hg38",
        "id": "chr4:g.152328232C>A"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057519895",
        "rs": 1057519895
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/4-152328232-C-A?dataset=gnomad_r4",
        "id": "4-152328232-C-A",
        "variant": "4:152328232 C / A"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "A",
          "end": 152328232,
          "referenceAllele": "C",
          "start": 152328231
        }
      ],
      "hgvs": [
        "NC_000004.12:g.152328232C>A",
        "CM000666.2:g.152328232C>A"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000052"
    },
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "A",
          "end": 153249384,
          "referenceAllele": "C",
          "start": 153249383
        }
      ],
      "hgvs": [
        "NC_000004.11:g.153249384C>A",
        "CM000666.1:g.153249384C>A"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000028"
    },
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "A",
          "end": 153468834,
          "referenceAllele": "C",
          "start": 153468833
        }
      ],
      "hgvs": [
        "NC_000004.10:g.153468834C>A"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000004"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 211789,
          "referenceAllele": "G",
          "start": 211788
        }
      ],
      "hgvs": [
        "NG_029466.1:g.211789G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS004405"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 213642,
          "referenceAllele": "G",
          "start": 213641
        }
      ],
      "hgvs": [
        "NG_029466.2:g.213642G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS616304"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1009,
          "referenceAllele": "G",
          "start": 1008
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000703551.1:c.*87G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000515367.1:n.*87G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS911789"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1098,
          "referenceAllele": "G",
          "start": 1097
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000703552.1:c.893G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000515368.1:p.Arg298Leu",
        "hgvsWellDefined": "ENSP00000515368.1:p.Arg298Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS911790"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2079,
          "referenceAllele": "G",
          "start": 2078
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000703553.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000515369.1:p.Arg465Leu",
        "hgvsWellDefined": "ENSP00000515369.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS911791"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1763,
          "referenceAllele": "G",
          "start": 1762
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000703554.1:c.*1041G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000515370.1:n.*1041G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS911792"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 724,
          "referenceAllele": "G",
          "start": 723
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000703555.1:c.*370G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000515371.1:n.*370G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS911793"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2572,
          "referenceAllele": "G",
          "start": 2571
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000281708.10:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000281708.3:p.Arg465Leu",
        "hgvsWellDefined": "ENSP00000281708.3:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743620",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000281708.10:c.1394G>T"
          },
          "RefSeq": {
            "hgvs": "NM_001349798.2:c.1394G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000281708.3:p.Arg465Leu"
          },
          "RefSeq": {
            "hgvs": "NP_001336727.1:p.Arg465Leu"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1234,
          "referenceAllele": "G",
          "start": 1233
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000296555.11:c.1040G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000296555.4:p.Arg347Leu",
        "hgvsWellDefined": "ENSP00000296555.4:p.Arg347Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS744438"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1250,
          "referenceAllele": "G",
          "start": 1249
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000393956.9:c.1154G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000377528.4:p.Arg385Leu",
        "hgvsWellDefined": "ENSP00000377528.4:p.Arg385Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS753193"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2586,
          "referenceAllele": "G",
          "start": 2585
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000603548.6:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474725.1:p.Arg465Leu",
        "hgvsWellDefined": "ENSP00000474725.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS761599"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 943,
          "referenceAllele": "G",
          "start": 942
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000647183.1:n.943G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS769278"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1395,
          "referenceAllele": "G",
          "start": 1394
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000263981.9:c.1154G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000263981.4:p.Arg385Leu",
        "hgvsWellDefined": "ENSP00000263981.4:p.Arg385Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS251387"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2624,
          "referenceAllele": "G",
          "start": 2623
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000281708.8:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000281708.3:p.Arg465Leu",
        "hgvsWellDefined": "ENSP00000281708.3:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS253017"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1220,
          "referenceAllele": "G",
          "start": 1219
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000296555.9:c.1040G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000296555.4:p.Arg347Leu",
        "hgvsWellDefined": "ENSP00000296555.4:p.Arg347Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS254336"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 943,
          "referenceAllele": "G",
          "start": 942
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000393956.7:c.866G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000377528.3:p.Arg289Leu",
        "hgvsWellDefined": "ENSP00000377528.3:p.Arg289Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS275896"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1574,
          "referenceAllele": "G",
          "start": 1573
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000603548.5:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474725.1:p.Arg465Leu",
        "hgvsWellDefined": "ENSP00000474725.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS398657"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 842,
          "referenceAllele": "G",
          "start": 841
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000603821.1:n.842G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS398778"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1469,
          "referenceAllele": "G",
          "start": 1468
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000603841.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474971.1:p.Arg465Leu",
        "hgvsWellDefined": "ENSP00000474971.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS398790"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 581,
          "referenceAllele": "G",
          "start": 580
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "ENST00000604069.1:n.581G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS398884"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825317257",
      "coordinates": [
        {
          "allele": "T",
          "end": 1217,
          "referenceAllele": "G",
          "start": 1216
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "NM_001013415.1:c.1040G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001013433.1:p.Arg347Leu",
        "hgvsWellDefined": "NP_001013433.1:p.Arg347Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008405"
    },
    {
      "@id": "http://reg.genome.network/allele/PA658655395",
      "coordinates": [
        {
          "allele": "T",
          "end": 1382,
          "referenceAllele": "G",
          "start": 1381
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "NM_018315.4:c.1154G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_060785.2:p.Arg385Leu",
        "hgvsWellDefined": "NP_060785.2:p.Arg385Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS035637"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645466288",
      "coordinates": [
        {
          "allele": "T",
          "end": 1556,
          "referenceAllele": "G",
          "start": 1555
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "NM_033632.3:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_361014.1:p.Arg465Leu",
        "hgvsWellDefined": "NP_361014.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS039806"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2569,
          "referenceAllele": "G",
          "start": 2568
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532083.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530385.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_011530385.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS099111"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2519,
          "referenceAllele": "G",
          "start": 2518
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532084.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530386.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_011530386.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS099112"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2426,
          "referenceAllele": "G",
          "start": 2425
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532085.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530387.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_011530387.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS099113"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2747,
          "referenceAllele": "G",
          "start": 2746
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532086.1:c.1310G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530388.1:p.Arg437Leu",
        "hgvsWellDefined": "XP_011530388.1:p.Arg437Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS099114"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2697,
          "referenceAllele": "G",
          "start": 2696
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532087.1:c.1310G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530389.1:p.Arg437Leu",
        "hgvsWellDefined": "XP_011530389.1:p.Arg437Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS099115"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1955,
          "referenceAllele": "G",
          "start": 1954
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532088.1:c.893G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530390.1:p.Arg298Leu",
        "hgvsWellDefined": "XP_011530390.1:p.Arg298Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS099116"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825317257",
      "coordinates": [
        {
          "allele": "T",
          "end": 1234,
          "referenceAllele": "G",
          "start": 1233
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "NM_001013415.2:c.1040G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001013433.1:p.Arg347Leu",
        "hgvsWellDefined": "NP_001013433.1:p.Arg347Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511028"
    },
    {
      "@id": "http://reg.genome.network/allele/PA891866340",
      "coordinates": [
        {
          "allele": "T",
          "end": 2572,
          "referenceAllele": "G",
          "start": 2571
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "NM_001349798.2:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001336727.1:p.Arg465Leu",
        "hgvsWellDefined": "NP_001336727.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS518952",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000281708.10:c.1394G>T"
          },
          "RefSeq": {
            "hgvs": "NM_001349798.2:c.1394G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000281708.3:p.Arg465Leu"
          },
          "RefSeq": {
            "hgvs": "NP_001336727.1:p.Arg465Leu"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA658655395",
      "coordinates": [
        {
          "allele": "T",
          "end": 1250,
          "referenceAllele": "G",
          "start": 1249
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "NM_018315.5:c.1154G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_060785.2:p.Arg385Leu",
        "hgvsWellDefined": "NP_060785.2:p.Arg385Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525898"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3303,
          "referenceAllele": "G",
          "start": 3302
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532084.2:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530386.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_011530386.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS550690"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3210,
          "referenceAllele": "G",
          "start": 3209
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532085.2:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530387.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_011530387.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS550691"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3531,
          "referenceAllele": "G",
          "start": 3530
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532086.2:c.1310G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530388.1:p.Arg437Leu",
        "hgvsWellDefined": "XP_011530388.1:p.Arg437Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS550692"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3481,
          "referenceAllele": "G",
          "start": 3480
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532087.2:c.1310G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530389.1:p.Arg437Leu",
        "hgvsWellDefined": "XP_011530389.1:p.Arg437Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS550693"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2733,
          "referenceAllele": "G",
          "start": 2732
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_011532088.2:c.893G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011530390.1:p.Arg298Leu",
        "hgvsWellDefined": "XP_011530390.1:p.Arg298Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS550694"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3446,
          "referenceAllele": "G",
          "start": 3445
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_024454121.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_024309889.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_024309889.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587491"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3705,
          "referenceAllele": "G",
          "start": 3704
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_024454122.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_024309890.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_024309890.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587492"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3401,
          "referenceAllele": "G",
          "start": 3400
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_024454123.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_024309891.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_024309891.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587493"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3657,
          "referenceAllele": "G",
          "start": 3656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_024454124.1:c.1394G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_024309892.1:p.Arg465Leu",
        "hgvsWellDefined": "XP_024309892.1:p.Arg465Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587494"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3624,
          "referenceAllele": "G",
          "start": 3623
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_024454125.1:c.1310G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_024309893.1:p.Arg437Leu",
        "hgvsWellDefined": "XP_024309893.1:p.Arg437Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587495"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2826,
          "referenceAllele": "G",
          "start": 2825
        }
      ],
      "gene": "http://reg.genome.network/gene/GN016712",
      "geneNCBI_id": 55294,
      "geneSymbol": "FBXW7",
      "hgvs": [
        "XM_024454126.1:c.893G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_024309894.1:p.Arg298Leu",
        "hgvsWellDefined": "XP_024309894.1:p.Arg298Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587496"
    }
  ],
  "type": "nucleotide"
}