{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1619118760",
  "communityStandardTitle": [
    "NM_005514.8(HLA-B):c.834G= (p.Glu278=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1065502",
        "rs": 1065502
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "C",
          "end": 31355378,
          "referenceAllele": "C",
          "start": 31355377
        }
      ],
      "hgvs": [
        "NC_000006.12:g.31355378C=",
        "CM000668.2:g.31355378C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000054"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "C",
          "end": 31323155,
          "referenceAllele": "C",
          "start": 31323154
        }
      ],
      "hgvs": [
        "NC_000006.11:g.31323155C=",
        "CM000668.1:g.31323155C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000030"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "C",
          "end": 31431134,
          "referenceAllele": "C",
          "start": 31431133
        }
      ],
      "hgvs": [
        "NC_000006.10:g.31431134C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000006"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 6835,
          "referenceAllele": "G",
          "start": 6834
        }
      ],
      "hgvs": [
        "NG_023187.1:g.6835G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003703"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2881,
          "referenceAllele": "G",
          "start": 2880
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000474381.2:n.2881G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS905216"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2307,
          "referenceAllele": "G",
          "start": 2306
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000481849.6:n.2307G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS905289"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2307,
          "referenceAllele": "G",
          "start": 2306
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000497377.6:n.2307G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS905445"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 834,
          "referenceAllele": "G",
          "start": 833
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000640094.2:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000491275.2:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS906383"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 903,
          "referenceAllele": "G",
          "start": 902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000696558.1:c.903G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512716.1:n.903G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908005"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1351,
          "referenceAllele": "G",
          "start": 1350
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000696559.1:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512717.1:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908006"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2362,
          "referenceAllele": "G",
          "start": 2361
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000696560.1:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512718.1:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908007"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1275,
          "referenceAllele": "G",
          "start": 1274
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000696561.1:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512719.1:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908008"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2267,
          "referenceAllele": "G",
          "start": 2266
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000696562.1:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512720.1:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908009"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 855,
          "referenceAllele": "G",
          "start": 854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000412585.7:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000399168.2:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754501",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000412585.7:c.834G="
          },
          "RefSeq": {
            "hgvs": "NM_005514.8:c.834G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000399168.2:p.Glu278="
          },
          "RefSeq": {
            "hgvs": "NP_005505.2:p.Glu278="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 27,
          "referenceAllele": "G",
          "start": 26
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000640094.1:c.27G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000491275.1:p.Glu9="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS765334"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 863,
          "referenceAllele": "G",
          "start": 862
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000412585.6:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000399168.2:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS282676"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 425,
          "referenceAllele": "G",
          "start": 424
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "ENST00000463574.1:n.425G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS307580"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829593615",
      "coordinates": [
        {
          "allele": "G",
          "end": 888,
          "referenceAllele": "G",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "NM_005514.6:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "NP_005505.2:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS030605"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 883,
          "referenceAllele": "G",
          "start": 882
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "XM_011514556.1:c.867G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011512858.1:p.Glu289="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081781"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 844,
          "referenceAllele": "G",
          "start": 843
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "XM_011514557.1:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011512859.1:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081782"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1273,
          "referenceAllele": "G",
          "start": 1272
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "XR_926175.1:n.1273G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS122789"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829593615",
      "coordinates": [
        {
          "allele": "G",
          "end": 921,
          "referenceAllele": "G",
          "start": 920
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "NM_005514.7:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "NP_005505.2:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525318"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829593615",
      "coordinates": [
        {
          "allele": "G",
          "end": 855,
          "referenceAllele": "G",
          "start": 854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN004932",
      "geneNCBI_id": 3106,
      "geneSymbol": "HLA-B",
      "hgvs": [
        "NM_005514.8:c.834G="
      ],
      "proteinEffect": {
        "hgvs": "NP_005505.2:p.Glu278="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS667005",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000412585.7:c.834G="
          },
          "RefSeq": {
            "hgvs": "NM_005514.8:c.834G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000399168.2:p.Glu278="
          },
          "RefSeq": {
            "hgvs": "NP_005505.2:p.Glu278="
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}