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        "hgvsWellDefined": "NP_001356320.1:p.[His278_Ser282delinsPro;Lys284_Pro286delinsLeuArg;Leu289_Leu290delinsLysGly;Pro292_Pro295delinsArgAlaThrAla;Pro297Thr;Glu299Ala;Glu301Thr;Ser303_Pro306del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691616"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1435,
          "referenceAllele": "",
          "start": 1435
        }
      ],
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      "geneNCBI_id": 4204,
      "geneSymbol": "MECP2",
      "hgvs": [
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      ],
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        "hgvsWellDefined": "NP_001356321.1:p.[His278_Ser282delinsPro;Lys284_Pro286delinsLeuArg;Leu289_Leu290delinsLysGly;Pro292_Pro295delinsArgAlaThrAla;Pro297Thr;Glu299Ala;Glu301Thr;Ser303_Pro306del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691617"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1311,
          "referenceAllele": "",
          "start": 1311
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006990",
      "geneNCBI_id": 4204,
      "geneSymbol": "MECP2",
      "hgvs": [
        "NM_001369393.2:c.832dup"
      ],
      "proteinEffect": {
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        "hgvsWellDefined": "NP_001356322.1:p.[His278_Ser282delinsPro;Lys284_Pro286delinsLeuArg;Leu289_Leu290delinsLysGly;Pro292_Pro295delinsArgAlaThrAla;Pro297Thr;Glu299Ala;Glu301Thr;Ser303_Pro306del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691618"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1242,
          "referenceAllele": "",
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        }
      ],
      "gene": "http://reg.genome.network/gene/GN006990",
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      "hgvs": [
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      ],
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        "hgvsWellDefined": "NP_001356323.1:p.[His278_Ser282delinsPro;Lys284_Pro286delinsLeuArg;Leu289_Leu290delinsLysGly;Pro292_Pro295delinsArgAlaThrAla;Pro297Thr;Glu299Ala;Glu301Thr;Ser303_Pro306del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691619"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1242,
          "referenceAllele": "",
          "start": 1242
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006990",
      "geneNCBI_id": 4204,
      "geneSymbol": "MECP2",
      "hgvs": [
        "NM_001369394.2:c.832dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001356323.1:p.His278ProfsTer22",
        "hgvsWellDefined": "NP_001356323.1:p.[His278_Ser282delinsPro;Lys284_Pro286delinsLeuArg;Leu289_Leu290delinsLysGly;Pro292_Pro295delinsArgAlaThrAla;Pro297Thr;Glu299Ala;Glu301Thr;Ser303_Pro306del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721143"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1326,
          "referenceAllele": "",
          "start": 1326
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
      "geneNCBI_id": 4204,
      "geneSymbol": "MECP2",
      "hgvs": [
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      ],
      "proteinEffect": {
        "hgvs": "NP_001373066.1:p.His148ProfsTer22",
        "hgvsWellDefined": "NP_001373066.1:p.[His148_Ser152delinsPro;Lys154_Pro156delinsLeuArg;Leu159_Leu160delinsLysGly;Pro162_Pro165delinsArgAlaThrAla;Pro167Thr;Glu169Ala;Glu171Thr;Ser173_Pro176del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724415"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1214,
          "referenceAllele": "",
          "start": 1214
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      ],
      "gene": "http://reg.genome.network/gene/GN006990",
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      "geneSymbol": "MECP2",
      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001373067.1:p.[His148_Ser152delinsPro;Lys154_Pro156delinsLeuArg;Leu159_Leu160delinsLysGly;Pro162_Pro165delinsArgAlaThrAla;Pro167Thr;Glu169Ala;Glu171Thr;Ser173_Pro176del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724416"
    },
    {
      "coordinates": [
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          "allele": "C",
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          "referenceAllele": "",
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      "gene": "http://reg.genome.network/gene/GN006990",
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      "hgvs": [
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      "proteinEffect": {
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        "hgvsWellDefined": "NP_001373068.1:p.[His148_Ser152delinsPro;Lys154_Pro156delinsLeuArg;Leu159_Leu160delinsLysGly;Pro162_Pro165delinsArgAlaThrAla;Pro167Thr;Glu169Ala;Glu171Thr;Ser173_Pro176del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS724417"
    },
    {
      "coordinates": [
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      "gene": "http://reg.genome.network/gene/GN006990",
      "geneNCBI_id": 4204,
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      "hgvs": [
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      ],
      "proteinEffect": {
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        "hgvsWellDefined": "NP_004983.1:p.[His371_Ser375delinsPro;Lys377_Pro379delinsLeuArg;Leu382_Leu383delinsLysGly;Pro385_Pro388delinsArgAlaThrAla;Pro390Thr;Glu392Ala;Glu394Thr;Ser396_Pro399del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS727571",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000303391.11:c.1111dup"
          },
          "RefSeq": {
            "hgvs": "NM_004992.4:c.1111dup"
          }
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        "protein": {
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          }
        }
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  "type": "nucleotide"
}