{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA16023181",
  "communityStandardTitle": [
    "NM_000038.6(APC):c.852G>A (p.Met284Ile)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr5:g.112151209G>A?assembly=hg19",
        "id": "chr5:g.112151209G>A"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr5:g.112815512G>A?assembly=hg38",
        "id": "chr5:g.112815512G>A"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/772181347",
        "rs": 772181347
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "A",
          "end": 112815512,
          "referenceAllele": "G",
          "start": 112815511
        }
      ],
      "hgvs": [
        "NC_000005.10:g.112815512G>A",
        "CM000667.2:g.112815512G>A"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000053"
    },
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "A",
          "end": 112151209,
          "referenceAllele": "G",
          "start": 112151208
        }
      ],
      "hgvs": [
        "NC_000005.9:g.112151209G>A",
        "CM000667.1:g.112151209G>A"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000029"
    },
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "A",
          "end": 112179108,
          "referenceAllele": "G",
          "start": 112179107
        }
      ],
      "hgvs": [
        "NC_000005.8:g.112179108G>A"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000005"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 127992,
          "referenceAllele": "G",
          "start": 127991
        }
      ],
      "hgvs": [
        "NG_008481.4:g.127992G>A",
        "LRG_130:g.127992G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001117"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 852,
          "referenceAllele": "G",
          "start": 851
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000502371.3:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484935.2:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000484935.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914176"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 908,
          "referenceAllele": "G",
          "start": 907
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000504915.3:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473355.2:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000473355.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914183"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 908,
          "referenceAllele": "G",
          "start": 907
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000505084.2:n.908G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS914184"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1232,
          "referenceAllele": "G",
          "start": 1231
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000505350.2:c.*858G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481752.1:n.*858G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914185"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 994,
          "referenceAllele": "G",
          "start": 993
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000507379.6:c.798G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423224.2:p.Met266Ile",
        "hgvsWellDefined": "ENSP00000423224.2:p.Met266Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914189"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1002,
          "referenceAllele": "G",
          "start": 1001
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000509732.6:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426541.2:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000426541.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914195"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1203,
          "referenceAllele": "G",
          "start": 1202
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000512211.7:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423828.3:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000423828.3:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914202"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 911,
          "referenceAllele": "G",
          "start": 910
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000257430.9:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000257430.4:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000257430.4:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS741831",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000257430.9:c.852G>A"
          },
          "RefSeq": {
            "hgvs": "NM_000038.6:c.852G>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000257430.4:p.Met284Ile"
          },
          "RefSeq": {
            "hgvs": "NP_000029.2:p.Met284Ile"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 908,
          "referenceAllele": "G",
          "start": 907
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000257430.8:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000257430.4:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000257430.4:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247400"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 994,
          "referenceAllele": "G",
          "start": 993
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000507379.5:c.798G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423224.1:p.Met266Ile",
        "hgvsWellDefined": "ENSP00000423224.1:p.Met266Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247315"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1009,
          "referenceAllele": "G",
          "start": 1008
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000508376.6:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000427089.2:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000427089.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247198"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1097,
          "referenceAllele": "G",
          "start": 1096
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000508624.5:c.*174G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424265.1:n.*174G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS339602"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 999,
          "referenceAllele": "G",
          "start": 998
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000512211.6:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423828.2:p.Met284Ile",
        "hgvsWellDefined": "ENSP00000423828.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247286"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825014021",
      "coordinates": [
        {
          "allele": "A",
          "end": 937,
          "referenceAllele": "G",
          "start": 936
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_000038.5:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000029.2:p.Met284Ile",
        "hgvsWellDefined": "NP_000029.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006103"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825626265",
      "coordinates": [
        {
          "allele": "A",
          "end": 1045,
          "referenceAllele": "G",
          "start": 1044
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127510.2:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120982.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001120982.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011634"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825637612",
      "coordinates": [
        {
          "allele": "A",
          "end": 1011,
          "referenceAllele": "G",
          "start": 1010
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127511.2:c.798G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120983.2:p.Met266Ile",
        "hgvsWellDefined": "NP_001120983.2:p.Met266Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011635"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827940343",
      "coordinates": [
        {
          "allele": "A",
          "end": 1248,
          "referenceAllele": "G",
          "start": 1247
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354895.1:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341824.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001341824.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522733"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827949515",
      "coordinates": [
        {
          "allele": "A",
          "end": 937,
          "referenceAllele": "G",
          "start": 936
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354896.1:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341825.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001341825.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522734"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827955206",
      "coordinates": [
        {
          "allele": "A",
          "end": 1095,
          "referenceAllele": "G",
          "start": 1094
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354897.1:c.882G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341826.1:p.Met294Ile",
        "hgvsWellDefined": "NP_001341826.1:p.Met294Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522735"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827964172",
      "coordinates": [
        {
          "allele": "A",
          "end": 892,
          "referenceAllele": "G",
          "start": 891
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354898.1:c.777G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341827.1:p.Met259Ile",
        "hgvsWellDefined": "NP_001341827.1:p.Met259Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522736"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827973331",
      "coordinates": [
        {
          "allele": "A",
          "end": 853,
          "referenceAllele": "G",
          "start": 852
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354899.1:c.768G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341828.1:p.Met256Ile",
        "hgvsWellDefined": "NP_001341828.1:p.Met256Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522737"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827982428",
      "coordinates": [
        {
          "allele": "A",
          "end": 784,
          "referenceAllele": "G",
          "start": 783
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354900.1:c.675G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341829.1:p.Met225Ile",
        "hgvsWellDefined": "NP_001341829.1:p.Met225Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522738"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827991507",
      "coordinates": [
        {
          "allele": "A",
          "end": 784,
          "referenceAllele": "G",
          "start": 783
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354901.1:c.675G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341830.1:p.Met225Ile",
        "hgvsWellDefined": "NP_001341830.1:p.Met225Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522739"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2499252481",
      "coordinates": [
        {
          "allele": "A",
          "end": 1095,
          "referenceAllele": "G",
          "start": 1094
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354902.1:c.882G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341831.1:p.Met294Ile",
        "hgvsWellDefined": "NP_001341831.1:p.Met294Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522740"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828015045",
      "coordinates": [
        {
          "allele": "A",
          "end": 937,
          "referenceAllele": "G",
          "start": 936
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354903.1:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341832.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001341832.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522741"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828032123",
      "coordinates": [
        {
          "allele": "A",
          "end": 892,
          "referenceAllele": "G",
          "start": 891
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354904.1:c.777G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341833.1:p.Met259Ile",
        "hgvsWellDefined": "NP_001341833.1:p.Met259Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522742"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828051776",
      "coordinates": [
        {
          "allele": "A",
          "end": 784,
          "referenceAllele": "G",
          "start": 783
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354905.1:c.675G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341834.1:p.Met225Ile",
        "hgvsWellDefined": "NP_001341834.1:p.Met225Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522743"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828014396",
      "coordinates": [
        {
          "allele": "A",
          "end": 1123,
          "referenceAllele": "G",
          "start": 1122
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354906.1:c.3G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341835.1:p.Met1Ile",
        "hgvsWellDefined": "NP_001341835.1:p.Met1Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522744"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825014021",
      "coordinates": [
        {
          "allele": "A",
          "end": 911,
          "referenceAllele": "G",
          "start": 910
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_000038.6:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000029.2:p.Met284Ile",
        "hgvsWellDefined": "NP_000029.2:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662295",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000257430.9:c.852G>A"
          },
          "RefSeq": {
            "hgvs": "NM_000038.6:c.852G>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000257430.4:p.Met284Ile"
          },
          "RefSeq": {
            "hgvs": "NP_000029.2:p.Met284Ile"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825626265",
      "coordinates": [
        {
          "allele": "A",
          "end": 1019,
          "referenceAllele": "G",
          "start": 1018
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127510.3:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120982.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001120982.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676902"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825637612",
      "coordinates": [
        {
          "allele": "A",
          "end": 1018,
          "referenceAllele": "G",
          "start": 1017
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127511.3:c.798G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120983.2:p.Met266Ile",
        "hgvsWellDefined": "NP_001120983.2:p.Met266Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676903"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827940343",
      "coordinates": [
        {
          "allele": "A",
          "end": 1255,
          "referenceAllele": "G",
          "start": 1254
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354895.2:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341824.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001341824.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690347"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827949515",
      "coordinates": [
        {
          "allele": "A",
          "end": 911,
          "referenceAllele": "G",
          "start": 910
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354896.2:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341825.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001341825.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690348"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827955206",
      "coordinates": [
        {
          "allele": "A",
          "end": 1102,
          "referenceAllele": "G",
          "start": 1101
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354897.2:c.882G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341826.1:p.Met294Ile",
        "hgvsWellDefined": "NP_001341826.1:p.Met294Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690349"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827964172",
      "coordinates": [
        {
          "allele": "A",
          "end": 866,
          "referenceAllele": "G",
          "start": 865
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354898.2:c.777G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341827.1:p.Met259Ile",
        "hgvsWellDefined": "NP_001341827.1:p.Met259Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690350"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827973331",
      "coordinates": [
        {
          "allele": "A",
          "end": 827,
          "referenceAllele": "G",
          "start": 826
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354899.2:c.768G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341828.1:p.Met256Ile",
        "hgvsWellDefined": "NP_001341828.1:p.Met256Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690351"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827982428",
      "coordinates": [
        {
          "allele": "A",
          "end": 758,
          "referenceAllele": "G",
          "start": 757
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354900.2:c.675G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341829.1:p.Met225Ile",
        "hgvsWellDefined": "NP_001341829.1:p.Met225Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690352"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827991507",
      "coordinates": [
        {
          "allele": "A",
          "end": 758,
          "referenceAllele": "G",
          "start": 757
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354901.2:c.675G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341830.1:p.Met225Ile",
        "hgvsWellDefined": "NP_001341830.1:p.Met225Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690353"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2499252481",
      "coordinates": [
        {
          "allele": "A",
          "end": 1102,
          "referenceAllele": "G",
          "start": 1101
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354902.2:c.882G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341831.1:p.Met294Ile",
        "hgvsWellDefined": "NP_001341831.1:p.Met294Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690354"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828015045",
      "coordinates": [
        {
          "allele": "A",
          "end": 911,
          "referenceAllele": "G",
          "start": 910
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354903.2:c.852G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341832.1:p.Met284Ile",
        "hgvsWellDefined": "NP_001341832.1:p.Met284Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690355"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828032123",
      "coordinates": [
        {
          "allele": "A",
          "end": 866,
          "referenceAllele": "G",
          "start": 865
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354904.2:c.777G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341833.1:p.Met259Ile",
        "hgvsWellDefined": "NP_001341833.1:p.Met259Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690356"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828051776",
      "coordinates": [
        {
          "allele": "A",
          "end": 758,
          "referenceAllele": "G",
          "start": 757
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354905.2:c.675G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341834.1:p.Met225Ile",
        "hgvsWellDefined": "NP_001341834.1:p.Met225Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690357"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828014396",
      "coordinates": [
        {
          "allele": "A",
          "end": 1097,
          "referenceAllele": "G",
          "start": 1096
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354906.2:c.3G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341835.1:p.Met1Ile",
        "hgvsWellDefined": "NP_001341835.1:p.Met1Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690358"
    }
  ],
  "type": "nucleotide"
}