{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA16022087",
  "communityStandardTitle": [
    "NM_000038.6(APC):c.350C>G (p.Ser117Ter)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr5:g.112103015C>G?assembly=hg19",
        "id": "chr5:g.112103015C>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr5:g.112767318C>G?assembly=hg38",
        "id": "chr5:g.112767318C>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1064793535",
        "rs": 1064793535
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "G",
          "end": 112767318,
          "referenceAllele": "C",
          "start": 112767317
        }
      ],
      "hgvs": [
        "NC_000005.10:g.112767318C>G",
        "CM000667.2:g.112767318C>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000053"
    },
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "G",
          "end": 112103015,
          "referenceAllele": "C",
          "start": 112103014
        }
      ],
      "hgvs": [
        "NC_000005.9:g.112103015C>G",
        "CM000667.1:g.112103015C>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000029"
    },
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "G",
          "end": 112130914,
          "referenceAllele": "C",
          "start": 112130913
        }
      ],
      "hgvs": [
        "NC_000005.8:g.112130914C>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000005"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 79798,
          "referenceAllele": "C",
          "start": 79797
        }
      ],
      "hgvs": [
        "NG_008481.4:g.79798C>G",
        "LRG_130:g.79798C>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001117"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 350,
          "referenceAllele": "C",
          "start": 349
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000502371.3:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484935.2:p.Ser117Ter",
        "hgvsWellDefined": "ENSP00000484935.2:p.Ser117_His488delinsPheProArgArgGlyPheValAsnGlySerArgGluSerThrGlyTyrLeuGluGluLeuGluLysGluArgSerLeuLeuLeuAlaAspLeuAspLysGluGluLysGluLysAspTrpTyrTyrAlaGlnLeuGlnAsnLeuThrLysArgIleAspSerLeuProLeuThrGluAsnPheSerLeuGlnThrAspMetThrArgArgGlnLeuGluTyrGluAlaArgGlnIleArgValAlaMetGluGluGlnLeuGlyThrCysGlnAspMetGluLysArgAlaGlnArgArgIleAlaArgIleGlnGlnIleGluLysAspIleLeuArgIleArgGlnLeuLeuGlnSerGlnAlaThrGluAlaGluArgSerSerGlnAsnLysHisGluThrGlySerHisAspAlaGluArgGlnAsnGluGlyGlnGlyValGlyGluIleAsnMetAlaThrSerGlyAsnGlyGlnGlySerThrThrArgMetAspHisGluThrAlaSerValLeuSerSerSerSerThrHisSerAlaProArgArgLeuThrSerHisLeuGlyThrLysValGluMetValTyrSerLeuLeuSerMetLeuGlyThrHisAspLysAspAspMetSerArgThrLeuLeuAlaMetSerSerSerGlnAspSerCysIleSerMetArgGlnSerGlyCysLeuProLeuLeuIleGlnLeuLeuHisGlyAsnAspLysAspSerValLeuLeuGlyAsnSerArgGlySerLysGluAlaArgAlaArgAlaSerAlaAlaLeuHisAsnIleIleHisSerGlnProAspAspLysArgGlyArgArgGluIleArgValLeuHisLeuLeuGluGlnIleArgAlaTyrCysGluThrCysTrpGluTrpGlnGluAlaHisGluProGlyMetAspGlnAspLysAsnProMetProAlaProValGluHisGlnIleCysProAlaValCysValLeuMetLysLeuSerPheAspGluGluHisArgHisAlaMetAsnGluLeuGlyIleAsnProGlnLysArgIleGluCysLeuMetGluPheValSerThrLeuHisTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914176"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 406,
          "referenceAllele": "C",
          "start": 405
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000504915.3:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473355.2:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914183"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 406,
          "referenceAllele": "C",
          "start": 405
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000505084.2:n.406C>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS914184"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 730,
          "referenceAllele": "C",
          "start": 729
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000505350.2:c.*356C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481752.1:n.*356C>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914185"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 576,
          "referenceAllele": "C",
          "start": 575
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000507379.6:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423224.2:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914189"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 500,
          "referenceAllele": "C",
          "start": 499
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000509732.6:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426541.2:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914195"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 701,
          "referenceAllele": "C",
          "start": 700
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000512211.7:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423828.3:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914202"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000257430.9:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000257430.4:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS741831",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000257430.9:c.350C>G"
          },
          "RefSeq": {
            "hgvs": "NM_000038.6:c.350C>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000257430.4:p.Ser117Ter"
          },
          "RefSeq": {
            "hgvs": "NP_000029.2:p.Ser117Ter"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 406,
          "referenceAllele": "C",
          "start": 405
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000257430.8:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000257430.4:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247400"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 576,
          "referenceAllele": "C",
          "start": 575
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000507379.5:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423224.1:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247315"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 507,
          "referenceAllele": "C",
          "start": 506
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000508376.6:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000427089.2:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247198"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000508624.5:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424265.1:p.Ser117Ter",
        "hgvsWellDefined": "ENSP00000424265.1:p.Ser117_Cys287delinsPheProArgArgGlyPheValAsnGlySerArgGluSerThrGlyTyrLeuGluGluLeuGluLysGluArgSerLeuLeuLeuAlaAspLeuAspLysGluGluLysGluLysAspTrpTyrTyrAlaGlnLeuGlnAsnLeuThrLysArgIleAspSerLeuProLeuThrGluAsnPheSerLeuGlnThrAspMetThrArgArgGlnLeuGluTyrGluAlaArgGlnIleArgValAlaMetGluGluGlnLeuGlyThrCysGlnAspMetGluLysArgAlaGlnArgArgIleAlaArgIleGlnGlnIleGluLysAspIleLeuArgIleArgGlnLeuLeuGlnSerGlnAlaThrGluAlaGluArgSerSerGlnAsnLysHisGluThrGlySerHisAspAlaGluArgGlnAsnGluGlyGlnGlyValGlyGluIleAsnMetAlaThrSerGlyAsnGlyGlnIleGluLysMetArgMetPheGluCysTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS339602"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 520,
          "referenceAllele": "C",
          "start": 519
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000509732.5:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426541.1:p.Ser117Ter",
        "hgvsWellDefined": "ENSP00000426541.1:p.Ser117_Phe118del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247336"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 497,
          "referenceAllele": "C",
          "start": 496
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000512211.6:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423828.2:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247286"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 435,
          "referenceAllele": "C",
          "start": 434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_000038.5:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000029.2:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006103"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 543,
          "referenceAllele": "C",
          "start": 542
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127510.2:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120982.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011634"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 593,
          "referenceAllele": "C",
          "start": 592
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127511.2:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120983.2:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011635"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 746,
          "referenceAllele": "C",
          "start": 745
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354895.1:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341824.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522733"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 435,
          "referenceAllele": "C",
          "start": 434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354896.1:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341825.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522734"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 593,
          "referenceAllele": "C",
          "start": 592
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354897.1:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341826.1:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522735"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 390,
          "referenceAllele": "C",
          "start": 389
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354898.1:c.275C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341827.1:p.Ser92Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522736"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 435,
          "referenceAllele": "C",
          "start": 434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354899.1:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341828.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522737"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 282,
          "referenceAllele": "C",
          "start": 281
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354900.1:c.173C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341829.1:p.Ser58Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522738"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 282,
          "referenceAllele": "C",
          "start": 281
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354901.1:c.173C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341830.1:p.Ser58Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522739"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 593,
          "referenceAllele": "C",
          "start": 592
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354902.1:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341831.1:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522740"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 435,
          "referenceAllele": "C",
          "start": 434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354903.1:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341832.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522741"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 390,
          "referenceAllele": "C",
          "start": 389
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354904.1:c.275C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341833.1:p.Ser92Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522742"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 282,
          "referenceAllele": "C",
          "start": 281
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354905.1:c.173C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341834.1:p.Ser58Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522743"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 435,
          "referenceAllele": "C",
          "start": 434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354906.1:c.-686C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341835.1:n.-686C>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522744"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_000038.6:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000029.2:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662295",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000257430.9:c.350C>G"
          },
          "RefSeq": {
            "hgvs": "NM_000038.6:c.350C>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000257430.4:p.Ser117Ter"
          },
          "RefSeq": {
            "hgvs": "NP_000029.2:p.Ser117Ter"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 517,
          "referenceAllele": "C",
          "start": 516
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127510.3:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120982.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676902"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 600,
          "referenceAllele": "C",
          "start": 599
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127511.3:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120983.2:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676903"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 753,
          "referenceAllele": "C",
          "start": 752
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354895.2:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341824.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690347"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354896.2:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341825.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690348"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 600,
          "referenceAllele": "C",
          "start": 599
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354897.2:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341826.1:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690349"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 364,
          "referenceAllele": "C",
          "start": 363
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354898.2:c.275C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341827.1:p.Ser92Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690350"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354899.2:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341828.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690351"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 256,
          "referenceAllele": "C",
          "start": 255
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354900.2:c.173C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341829.1:p.Ser58Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690352"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 256,
          "referenceAllele": "C",
          "start": 255
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354901.2:c.173C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341830.1:p.Ser58Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690353"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 600,
          "referenceAllele": "C",
          "start": 599
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354902.2:c.380C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341831.1:p.Ser127Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690354"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354903.2:c.350C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341832.1:p.Ser117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690355"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 364,
          "referenceAllele": "C",
          "start": 363
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354904.2:c.275C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341833.1:p.Ser92Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690356"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 256,
          "referenceAllele": "C",
          "start": 255
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354905.2:c.173C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341834.1:p.Ser58Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690357"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 409,
          "referenceAllele": "C",
          "start": 408
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354906.2:c.-686C>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341835.1:n.-686C>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690358"
    }
  ],
  "type": "nucleotide"
}