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        "NM_001145103.2:c.527-4011A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138575.1:n.527-4011A>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712752"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 159,
          "endIntronDirection": "-",
          "endIntronOffset": 4010,
          "referenceAllele": "A",
          "start": 159,
          "startIntronDirection": "-",
          "startIntronOffset": 4011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006769",
      "geneNCBI_id": 4088,
      "geneSymbol": "SMAD3",
      "hgvs": [
        "NM_001145104.2:c.74-4011A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138576.1:n.74-4011A>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712753"
    }
  ],
  "type": "nucleotide"
}