{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1519908124",
  "communityStandardTitle": [
    "NM_000892.5(KLKB1):c.598+1601G="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/71640036",
        "rs": 71640036
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "G",
          "end": 186239966,
          "referenceAllele": "G",
          "start": 186239965
        }
      ],
      "hgvs": [
        "NC_000004.12:g.186239966G=",
        "CM000666.2:g.186239966G="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000052"
    },
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "G",
          "end": 187161120,
          "referenceAllele": "G",
          "start": 187161119
        }
      ],
      "hgvs": [
        "NC_000004.11:g.187161120G=",
        "CM000666.1:g.187161120G="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000028"
    },
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "G",
          "end": 187398114,
          "referenceAllele": "G",
          "start": 187398113
        }
      ],
      "hgvs": [
        "NC_000004.10:g.187398114G="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000004"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 35988,
          "referenceAllele": "G",
          "start": 35987
        }
      ],
      "hgvs": [
        "NG_012095.2:g.35988G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002179"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 680,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 680,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "ENST00000264690.11:c.598+1601G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000264690.6:n.598+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS742712",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000264690.11:c.598+1601G="
          },
          "RefSeq": {
            "hgvs": "NM_000892.5:c.598+1601G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000264690.6:n.598+1601G="
          },
          "RefSeq": {
            "hgvs": "NP_000883.2:n.598+1601G="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 785,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 785,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "ENST00000264690.10:c.598+1601G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000264690.6:n.598+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS251560"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 628,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 628,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "ENST00000511406.5:n.628+1601G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS341682"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 741,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 741,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "ENST00000511608.5:c.741+1601G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS341835"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 738,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 738,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "ENST00000513864.2:c.484+1601G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424469.2:n.484+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS343495"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 669,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 669,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_000892.3:c.598+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000883.2:n.598+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006919"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 702,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 702,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_011531930.1:c.631+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011530232.1:n.631+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS098960"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4587,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 4587,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_011531931.1:c.631+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011530233.1:n.631+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS098961"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4723,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 4723,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_011531932.1:c.517+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011530234.1:n.517+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS098962"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4537,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 4537,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_011531933.1:c.517+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011530235.1:n.517+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS098963"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 593,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 593,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_011531934.1:c.-40+1601G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011530236.1:n.-40+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS098964"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 716,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 716,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_000892.4:c.598+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000883.2:n.598+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS510866"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 785,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 785,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_001318394.1:c.484+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001305323.1:n.484+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS512879"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 716,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 716,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_001318396.1:c.-40+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001305325.1:n.-40+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS512881"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 702,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 702,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_011531930.2:c.631+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011530232.1:n.631+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS550624"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1466,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 1466,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_017008181.1:c.631+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016863670.1:n.631+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS562736"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 702,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 702,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_017008182.1:c.631+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016863671.1:n.631+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS562737"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 669,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 669,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_017008183.1:c.598+1601G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016863672.1:n.598+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS562738"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 87,
          "endIntronDirection": "+",
          "endIntronOffset": 1568,
          "referenceAllele": "G",
          "start": 87,
          "startIntronDirection": "+",
          "startIntronOffset": 1567
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "XM_017008184.1:c.-40+1568G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016863673.1:n.-40+1568G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS562739"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 680,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 680,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_000892.5:c.598+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000883.2:n.598+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662632",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000264690.11:c.598+1601G="
          },
          "RefSeq": {
            "hgvs": "NM_000892.5:c.598+1601G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000264690.6:n.598+1601G="
          },
          "RefSeq": {
            "hgvs": "NP_000883.2:n.598+1601G="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 749,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 749,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_001318394.2:c.484+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001305323.1:n.484+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684517"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 680,
          "endIntronDirection": "+",
          "endIntronOffset": 1601,
          "referenceAllele": "G",
          "start": 680,
          "startIntronDirection": "+",
          "startIntronOffset": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006371",
      "geneNCBI_id": 3818,
      "geneSymbol": "KLKB1",
      "hgvs": [
        "NM_001318396.2:c.-40+1601G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001305325.1:n.-40+1601G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684519"
    }
  ],
  "type": "nucleotide"
}