{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA14971097",
  "communityStandardTitle": [
    "NM_000754.4(COMT):c.615+310C>T"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr22:g.19952132C>T?assembly=hg19",
        "id": "chr22:g.19952132C>T"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr22:g.19964609C>T?assembly=hg38",
        "id": "chr22:g.19964609C>T"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/4646316",
        "rs": 4646316
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/22-19952132-C-T?dataset=gnomad_r2_1",
        "id": "22-19952132-C-T",
        "variant": "22:19952132 C / T"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/22-19964609-C-T?dataset=gnomad_r3",
        "id": "22-19964609-C-T",
        "variant": "22:19964609 C / T"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/22-19964609-C-T?dataset=gnomad_r4",
        "id": "22-19964609-C-T",
        "variant": "22:19964609 C / T"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "T",
          "end": 19964609,
          "referenceAllele": "C",
          "start": 19964608
        }
      ],
      "hgvs": [
        "NC_000022.11:g.19964609C>T",
        "CM000684.2:g.19964609C>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000070"
    },
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "T",
          "end": 19952132,
          "referenceAllele": "C",
          "start": 19952131
        }
      ],
      "hgvs": [
        "NC_000022.10:g.19952132C>T",
        "CM000684.1:g.19952132C>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000046"
    },
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "T",
          "end": 18332132,
          "referenceAllele": "C",
          "start": 18332131
        }
      ],
      "hgvs": [
        "NC_000022.9:g.18332132C>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000022"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 27870,
          "referenceAllele": "C",
          "start": 27869
        }
      ],
      "hgvs": [
        "NG_011526.1:g.27870C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001793"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 832,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 832,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000361682.11:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000354511.6:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS749519",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000361682.11:c.615+310C>T"
          },
          "RefSeq": {
            "hgvs": "NM_000754.4:c.615+310C>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000354511.6:n.615+310C>T"
          },
          "RefSeq": {
            "hgvs": "NP_000745.1:n.615+310C>T"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 733,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 733,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000428707.2:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000387695.2:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS755236"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 911,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 911,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000676678.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000503719.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS776354"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 486,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 486,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000677397.1:c.465+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000503422.1:n.465+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS777059"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 465,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 465,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000677470.1:n.465+310C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS777132"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 398,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 398,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000677564.1:n.398+310C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS777225"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 415,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 415,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000677675.1:n.415+310C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS777333"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1699,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1699,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000678255.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000504402.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS777903"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 770,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 770,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000678769.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000503289.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS778407"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 985,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 985,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000678868.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000503583.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS778505"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 483,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 483,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000678945.1:n.483+310C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS778582"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 838,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 838,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000207636.9:c.*73+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000207636.5:n.*73+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247841"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 997,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 997,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000361682.10:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000354511.6:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS265597"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1181,
          "referenceAllele": "C",
          "start": 1180
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000403184.5:c.*217C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000383966.1:n.*217C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS279742"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1125,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1125,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000403710.5:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385917.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS279881"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 858,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 858,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000406520.7:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385150.3:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280660"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 994,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 994,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000407537.5:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000384654.2:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280938"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 817,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 817,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000412786.5:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000403958.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS282770"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 193,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 193,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000428707.1:c.193+310C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS290325"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 572,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 572,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "ENST00000449653.5:c.465+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416778.1:n.465+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS300322"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 864,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 864,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_000754.3:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000745.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006786"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 822,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 822,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_001135161.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001128633.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS012370"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 839,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 839,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_001135162.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001128634.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS012371"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 595,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 595,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_007310.2:c.465+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_009294.1:n.465+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS032219"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 769,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 769,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529885.1:c.729+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528187.1:n.729+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096944"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 769,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 769,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529886.1:c.729+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528188.1:n.729+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096945"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 811,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 811,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529887.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528189.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096946"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 853,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 853,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529888.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528190.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096947"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 859,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529889.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528191.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096948"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1088,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1088,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529890.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528192.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096949"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1032,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1032,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529891.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528193.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS096950"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1158,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1158,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_001362828.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001349757.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS523081"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2069,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 2069,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_011529886.2:c.1026+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011528188.2:n.1026+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS549703"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1032,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1032,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "XM_017028595.1:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016884084.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS578298"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 832,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 832,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_000754.4:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000745.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674944",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000361682.11:c.615+310C>T"
          },
          "RefSeq": {
            "hgvs": "NM_000754.4:c.615+310C>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000354511.6:n.615+310C>T"
          },
          "RefSeq": {
            "hgvs": "NP_000745.1:n.615+310C>T"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 857,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 857,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_001135161.2:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001128633.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677288"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 843,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 843,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_001135162.2:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001128634.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677289"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1126,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 1126,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_001362828.2:c.615+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001349757.1:n.615+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690554"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 589,
          "endIntronDirection": "+",
          "endIntronOffset": 310,
          "referenceAllele": "C",
          "start": 589,
          "startIntronDirection": "+",
          "startIntronOffset": 309
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002228",
      "geneNCBI_id": 1312,
      "geneSymbol": "COMT",
      "hgvs": [
        "NM_007310.3:c.465+310C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_009294.1:n.465+310C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS696966"
    }
  ],
  "type": "nucleotide"
}