{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA14920925",
  "communityStandardTitle": [
    "NM_002745.5(MAPK1):c.857-3854A>C"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "active": false,
        "id": "COSN6692198"
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr22:g.22131125T>G?assembly=hg19",
        "id": "chr22:g.22131125T>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr22:g.21776836T>G?assembly=hg38",
        "id": "chr22:g.21776836T>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/2283792",
        "rs": 2283792
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/22-22131125-T-G?dataset=gnomad_r2_1",
        "id": "22-22131125-T-G",
        "variant": "22:22131125 T / G"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/22-21776836-T-G?dataset=gnomad_r3",
        "id": "22-21776836-T-G",
        "variant": "22:21776836 T / G"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/22-21776836-T-G?dataset=gnomad_r4",
        "id": "22-21776836-T-G",
        "variant": "22:21776836 T / G"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "G",
          "end": 21776836,
          "referenceAllele": "T",
          "start": 21776835
        }
      ],
      "hgvs": [
        "NC_000022.11:g.21776836T>G",
        "CM000684.2:g.21776836T>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000070"
    },
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "G",
          "end": 22131125,
          "referenceAllele": "T",
          "start": 22131124
        }
      ],
      "hgvs": [
        "NC_000022.10:g.22131125T>G",
        "CM000684.1:g.22131125T>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000046"
    },
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "G",
          "end": 20461125,
          "referenceAllele": "T",
          "start": 20461124
        }
      ],
      "hgvs": [
        "NC_000022.9:g.20461125T>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000022"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 95845,
          "referenceAllele": "A",
          "start": 95844
        }
      ],
      "hgvs": [
        "NG_023054.2:g.95845A>C",
        "LRG_786:g.95845A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003698"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1061,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 1061,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "ENST00000215832.11:c.857-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000215832.7:n.857-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740242",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000215832.11:c.857-3854A>C"
          },
          "RefSeq": {
            "hgvs": "NM_002745.5:c.857-3854A>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000215832.7:n.857-3854A>C"
          },
          "RefSeq": {
            "hgvs": "NP_002736.3:n.857-3854A>C"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1045,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 1045,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "ENST00000215832.10:c.857-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000215832.6:n.857-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247909"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1096,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 1096,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "ENST00000398822.7:c.857-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000381803.3:n.857-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS278434"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 724,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 724,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "ENST00000544786.1:c.725-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000440842.1:n.725-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS364749"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1096,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 1096,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "NM_002745.4:c.857-3854A>C",
        "LRG_786t1:c.857-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_002736.3:n.857-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS028032"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1096,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 1096,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "NM_138957.3:c.857-3854A>C",
        "LRG_786t2:c.857-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_620407.1:n.857-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS040917"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1061,
          "endIntronDirection": "-",
          "endIntronOffset": 3853,
          "referenceAllele": "A",
          "start": 1061,
          "startIntronDirection": "-",
          "startIntronOffset": 3854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006871",
      "geneNCBI_id": 5594,
      "geneSymbol": "MAPK1",
      "hgvs": [
        "NM_002745.5:c.857-3854A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_002736.3:n.857-3854A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS695627",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000215832.11:c.857-3854A>C"
          },
          "RefSeq": {
            "hgvs": "NM_002745.5:c.857-3854A>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000215832.7:n.857-3854A>C"
          },
          "RefSeq": {
            "hgvs": "NP_002736.3:n.857-3854A>C"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}