{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1286883449",
  "communityStandardTitle": [
    "NM_000312.4(PROC):c.659G= (p.Arg220=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/121918153",
        "rs": 121918153
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "2",
      "coordinates": [
        {
          "allele": "G",
          "end": 127426208,
          "referenceAllele": "G",
          "start": 127426207
        }
      ],
      "hgvs": [
        "NC_000002.12:g.127426208G=",
        "CM000664.2:g.127426208G="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000050"
    },
    {
      "chromosome": "2",
      "coordinates": [
        {
          "allele": "G",
          "end": 128183784,
          "referenceAllele": "G",
          "start": 128183783
        }
      ],
      "hgvs": [
        "NC_000002.11:g.128183784G=",
        "CM000664.1:g.128183784G="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000026"
    },
    {
      "chromosome": "2",
      "coordinates": [
        {
          "allele": "G",
          "end": 127900254,
          "referenceAllele": "G",
          "start": 127900253
        }
      ],
      "hgvs": [
        "NC_000002.10:g.127900254G="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000002"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 12789,
          "referenceAllele": "G",
          "start": 12788
        }
      ],
      "hgvs": [
        "NG_016323.1:g.12789G=",
        "LRG_599:g.12789G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003093"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 746,
          "referenceAllele": "G",
          "start": 745
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "ENST00000234071.8:c.659G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000234071.4:p.Arg220="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740940",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000234071.8:c.659G="
          },
          "RefSeq": {
            "hgvs": "NM_000312.4:c.659G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000234071.4:p.Arg220="
          },
          "RefSeq": {
            "hgvs": "NP_000303.1:p.Arg220="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 746,
          "referenceAllele": "G",
          "start": 745
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "ENST00000234071.7:c.659G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000234071.3:p.Arg220="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS248899"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 120,
          "endIntronDirection": "-",
          "endIntronOffset": 2148,
          "referenceAllele": "G",
          "start": 120,
          "startIntronDirection": "-",
          "startIntronOffset": 2149
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "ENST00000402125.2:c.121-2149G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS279415"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 822,
          "referenceAllele": "G",
          "start": 821
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "ENST00000409048.1:c.761G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000386679.1:p.Arg254="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS281212"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 245,
          "referenceAllele": "G",
          "start": 244
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "ENST00000464089.1:n.245G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS307992"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825116601",
      "coordinates": [
        {
          "allele": "G",
          "end": 753,
          "referenceAllele": "G",
          "start": 752
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_000312.3:c.659G=",
        "LRG_599t1:c.659G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000303.1:p.Arg220="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006374"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 856,
          "referenceAllele": "G",
          "start": 855
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_005263715.3:c.842G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005263772.1:p.Arg281="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS063924"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 866,
          "referenceAllele": "G",
          "start": 865
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_005263716.3:c.824G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005263773.1:p.Arg275="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS063925"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 749,
          "referenceAllele": "G",
          "start": 748
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_005263717.3:c.722G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005263774.1:p.Arg241="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS063926"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 749,
          "referenceAllele": "G",
          "start": 748
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_005263717.4:c.722G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005263774.1:p.Arg241="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS535743"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 917,
          "referenceAllele": "G",
          "start": 916
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_017004505.1:c.902G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016859994.1:p.Arg301="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS559993"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1097,
          "referenceAllele": "G",
          "start": 1096
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_024453002.1:c.1004G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024308770.1:p.Arg335="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS586389"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 999,
          "referenceAllele": "G",
          "start": 998
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_024453003.1:c.944G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024308771.1:p.Arg315="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS586390"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 897,
          "referenceAllele": "G",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_024453004.1:c.842G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024308772.1:p.Arg281="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS586391"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 868,
          "referenceAllele": "G",
          "start": 867
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_024453005.1:c.824G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024308773.1:p.Arg275="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS586392"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 849,
          "referenceAllele": "G",
          "start": 848
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "XM_024453006.1:c.761G="
      ],
      "proteinEffect": {
        "hgvs": "XP_024308774.1:p.Arg254="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS586393"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 4377,
          "referenceAllele": "C",
          "start": 4376
        }
      ],
      "hgvs": [
        "XR_923313.2:n.4377C="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS607340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825116601",
      "coordinates": [
        {
          "allele": "G",
          "end": 746,
          "referenceAllele": "G",
          "start": 745
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_000312.4:c.659G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000303.1:p.Arg220="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674786",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000234071.8:c.659G="
          },
          "RefSeq": {
            "hgvs": "NM_000312.4:c.659G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000234071.4:p.Arg220="
          },
          "RefSeq": {
            "hgvs": "NP_000303.1:p.Arg220="
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828620368",
      "coordinates": [
        {
          "allele": "G",
          "end": 862,
          "referenceAllele": "G",
          "start": 861
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375602.1:c.842G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362531.1:p.Arg281="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693696"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828620657",
      "coordinates": [
        {
          "allele": "G",
          "end": 844,
          "referenceAllele": "G",
          "start": 843
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375603.1:c.824G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362532.1:p.Arg275="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693697"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828620941",
      "coordinates": [
        {
          "allele": "G",
          "end": 742,
          "referenceAllele": "G",
          "start": 741
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375604.1:c.722G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362533.1:p.Arg241="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693698"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828621227",
      "coordinates": [
        {
          "allele": "G",
          "end": 848,
          "referenceAllele": "G",
          "start": 847
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375605.1:c.761G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362534.1:p.Arg254="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693699"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828621517",
      "coordinates": [
        {
          "allele": "G",
          "end": 847,
          "referenceAllele": "G",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375606.1:c.827G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362535.1:p.Arg276="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693700"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828621741",
      "coordinates": [
        {
          "allele": "G",
          "end": 865,
          "referenceAllele": "G",
          "start": 864
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375607.1:c.845G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362536.1:p.Arg282="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693701"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828621894",
      "coordinates": [
        {
          "allele": "G",
          "end": 689,
          "referenceAllele": "G",
          "start": 688
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375608.1:c.602G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362537.1:p.Arg201="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693702"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828622161",
      "coordinates": [
        {
          "allele": "G",
          "end": 655,
          "referenceAllele": "G",
          "start": 654
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375609.1:c.635G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362538.1:p.Arg212="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693703"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828622436",
      "coordinates": [
        {
          "allele": "G",
          "end": 740,
          "referenceAllele": "G",
          "start": 739
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375610.1:c.653G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362539.1:p.Arg218="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693704"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828622713",
      "coordinates": [
        {
          "allele": "G",
          "end": 762,
          "referenceAllele": "G",
          "start": 761
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375611.1:c.659G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362540.1:p.Arg220="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693705"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828623028",
      "coordinates": [
        {
          "allele": "G",
          "end": 905,
          "referenceAllele": "G",
          "start": 904
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009451",
      "geneNCBI_id": 5624,
      "geneSymbol": "PROC",
      "hgvs": [
        "NM_001375613.1:c.659G="
      ],
      "proteinEffect": {
        "hgvs": "NP_001362542.1:p.Arg220="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693707"
    }
  ],
  "type": "nucleotide"
}