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        "hgvsWellDefined": "NP_001369323.1:p.[Arg1077_Leu1080delinsLysAsn;Pro1082_Ala1085delinsValAsnThr;Gly1087del;Ser1089_Val1094delinsCysPheTrp;Ser1096_Pro1105delinsPheGlnTyrHisArgCysLeuGlnCysIle]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS722322"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3877,
          "referenceAllele": "",
          "start": 3877
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011187",
      "geneNCBI_id": 6654,
      "geneSymbol": "SOS1",
      "hgvs": [
        "NM_001382395.1:c.3248dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001369324.1:p.Arg1084LysfsTer23",
        "hgvsWellDefined": "NP_001369324.1:p.[Arg1084_Leu1087delinsLysAsn;Pro1089_Ala1092delinsValAsnThr;Gly1094del;Ser1096_Val1101delinsCysPheTrp;Ser1103_Pro1112delinsPheGlnTyrHisArgCysLeuGlnCysIle]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS722323"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3877,
          "referenceAllele": "",
          "start": 3877
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011187",
      "geneNCBI_id": 6654,
      "geneSymbol": "SOS1",
      "hgvs": [
        "NM_005633.4:c.3248dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_005624.2:p.Arg1084LysfsTer23",
        "hgvsWellDefined": "NP_005624.2:p.[Arg1084_Leu1087delinsLysAsn;Pro1089_Ala1092delinsValAsnThr;Gly1094del;Ser1096_Val1101delinsCysPheTrp;Ser1103_Pro1112delinsPheGlnTyrHisArgCysLeuGlnCysIle]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS727653",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000402219.8:c.3248dup"
          },
          "RefSeq": {
            "hgvs": "NM_005633.4:c.3248dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000384675.2:p.Arg1084LysfsTer23"
          },
          "RefSeq": {
            "hgvs": "NP_005624.2:p.Arg1084LysfsTer23"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}