{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA12203848",
  "communityStandardTitle": [
    "NM_001455.4(FOXO3):c.*35-2125G>C"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr6:g.108998905G>C?assembly=hg19",
        "id": "chr6:g.108998905G>C"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr6:g.108677702G>C?assembly=hg38",
        "id": "chr6:g.108677702G>C"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1935952",
        "rs": 1935952
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-108998905-G-C?dataset=gnomad_r2_1",
        "id": "6-108998905-G-C",
        "variant": "6:108998905 G / C"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-108677702-G-C?dataset=gnomad_r3",
        "id": "6-108677702-G-C",
        "variant": "6:108677702 G / C"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-108677702-G-C?dataset=gnomad_r4",
        "id": "6-108677702-G-C",
        "variant": "6:108677702 G / C"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "C",
          "end": 108677702,
          "referenceAllele": "G",
          "start": 108677701
        }
      ],
      "hgvs": [
        "NC_000006.12:g.108677702G>C",
        "CM000668.2:g.108677702G>C"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000054"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "C",
          "end": 108998905,
          "referenceAllele": "G",
          "start": 108998904
        }
      ],
      "hgvs": [
        "NC_000006.11:g.108998905G>C",
        "CM000668.1:g.108998905G>C"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000030"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "C",
          "end": 109105598,
          "referenceAllele": "G",
          "start": 109105597
        }
      ],
      "hgvs": [
        "NC_000006.10:g.109105598G>C"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000006"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2348,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2348,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000406360.2:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385824.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754154",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000406360.2:c.*35-2125G>C"
          },
          "RefSeq": {
            "hgvs": "NM_001455.4:c.*35-2125G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000385824.1:n.*35-2125G>C"
          },
          "RefSeq": {
            "hgvs": "NP_001446.1:n.*35-2125G>C"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2360,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2360,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000343882.10:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000339527.6:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS261853"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2399,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2399,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000406360.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385824.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280609"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1628,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1628,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000540898.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000446316.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS362647"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2399,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2399,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_001455.3:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001446.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS026837"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2372,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2372,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_201559.2:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_963853.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS045063"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1635,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1635,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_005266867.3:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005266924.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS065209"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1649,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1649,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_005266868.2:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005266925.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS065210"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1570,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1570,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535626.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533928.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102629"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1587,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1587,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535627.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533929.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102630"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1559,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1559,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535628.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533930.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102631"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1534,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1534,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535629.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533931.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102632"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1620,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1620,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_005266867.4:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005266924.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS536307"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1644,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1644,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_005266868.3:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005266925.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS536308"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1675,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1675,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535626.2:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533928.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552102"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 6098,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 6098,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535628.3:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533930.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552103"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1593,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 1593,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535629.2:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533931.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552104"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3305,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 3305,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_017010585.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016866074.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564612"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3188,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 3188,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_017010586.1:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016866075.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564613"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2348,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2348,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_001455.4:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001446.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664999",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000406360.2:c.*35-2125G>C"
          },
          "RefSeq": {
            "hgvs": "NM_001455.4:c.*35-2125G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000385824.1:n.*35-2125G>C"
          },
          "RefSeq": {
            "hgvs": "NP_001446.1:n.*35-2125G>C"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2370,
          "endIntronDirection": "-",
          "endIntronOffset": 2124,
          "referenceAllele": "G",
          "start": 2370,
          "startIntronDirection": "-",
          "startIntronOffset": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_201559.3:c.*35-2125G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_963853.1:n.*35-2125G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701570"
    }
  ],
  "type": "nucleotide"
}