{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA12203829",
  "communityStandardTitle": [
    "NM_001455.4(FOXO3):c.621+25486G>T"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=1258591[alleleid]",
        "alleleId": 1258591,
        "preferredName": "NM_001455.4(FOXO3):c.621+25486G>T"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/1269978",
        "RCV": [
          "RCV001684136"
        ],
        "variationId": 1269978
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr6:g.108908518G>T?assembly=hg19",
        "id": "chr6:g.108908518G>T"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr6:g.108587315G>T?assembly=hg38",
        "id": "chr6:g.108587315G>T"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/2802292",
        "rs": 2802292
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-108908518-G-T?dataset=gnomad_r2_1",
        "id": "6-108908518-G-T",
        "variant": "6:108908518 G / T"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-108587315-G-T?dataset=gnomad_r3",
        "id": "6-108587315-G-T",
        "variant": "6:108587315 G / T"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-108587315-G-T?dataset=gnomad_r4",
        "id": "6-108587315-G-T",
        "variant": "6:108587315 G / T"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "T",
          "end": 108587315,
          "referenceAllele": "G",
          "start": 108587314
        }
      ],
      "hgvs": [
        "NC_000006.12:g.108587315G>T",
        "CM000668.2:g.108587315G>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000054"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "T",
          "end": 108908518,
          "referenceAllele": "G",
          "start": 108908517
        }
      ],
      "hgvs": [
        "NC_000006.11:g.108908518G>T",
        "CM000668.1:g.108908518G>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000030"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "T",
          "end": 109015211,
          "referenceAllele": "G",
          "start": 109015210
        }
      ],
      "hgvs": [
        "NC_000006.10:g.109015211G>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000006"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 913,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 913,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000406360.2:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385824.1:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754154",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000406360.2:c.621+25486G>T"
          },
          "RefSeq": {
            "hgvs": "NM_001455.4:c.621+25486G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000385824.1:n.621+25486G>T"
          },
          "RefSeq": {
            "hgvs": "NP_001446.1:n.621+25486G>T"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 925,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 925,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000343882.10:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000339527.6:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS261853"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 964,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 964,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "ENST00000406360.1:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385824.1:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280609"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 964,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 964,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_001455.3:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001446.1:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS026837"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 937,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 937,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_201559.2:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_963853.1:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS045063"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 83,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 83,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_005266867.3:c.-64+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_005266924.1:n.-64+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS065209"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 135,
          "endIntronDirection": "+",
          "endIntronOffset": 25172,
          "referenceAllele": "G",
          "start": 135,
          "startIntronDirection": "+",
          "startIntronOffset": 25171
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535626.1:c.120+25172G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533928.1:n.120+25172G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102629"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 152,
          "endIntronDirection": "+",
          "endIntronOffset": 679,
          "referenceAllele": "G",
          "start": 152,
          "startIntronDirection": "+",
          "startIntronOffset": 678
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535627.1:c.69+679G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533929.1:n.69+679G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102630"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 68,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 68,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_005266867.4:c.-64+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_005266924.1:n.-64+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS536307"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 240,
          "endIntronDirection": "+",
          "endIntronOffset": 25172,
          "referenceAllele": "G",
          "start": 240,
          "startIntronDirection": "+",
          "startIntronOffset": 25171
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535626.2:c.120+25172G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533928.1:n.120+25172G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552102"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2163,
          "referenceAllele": "G",
          "start": 2162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_011535628.3:c.-2540G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533930.1:n.-2540G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552103"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1753,
          "endIntronDirection": "+",
          "endIntronOffset": 17573,
          "referenceAllele": "G",
          "start": 1753,
          "startIntronDirection": "+",
          "startIntronOffset": 17572
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_017010585.1:c.-64+17573G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016866074.1:n.-64+17573G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564612"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1753,
          "endIntronDirection": "+",
          "endIntronOffset": 17573,
          "referenceAllele": "G",
          "start": 1753,
          "startIntronDirection": "+",
          "startIntronOffset": 17572
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "XM_017010586.1:c.-40+17573G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016866075.1:n.-40+17573G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564613"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 913,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 913,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_001455.4:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001446.1:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664999",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000406360.2:c.621+25486G>T"
          },
          "RefSeq": {
            "hgvs": "NM_001455.4:c.621+25486G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000385824.1:n.621+25486G>T"
          },
          "RefSeq": {
            "hgvs": "NP_001446.1:n.621+25486G>T"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 935,
          "endIntronDirection": "+",
          "endIntronOffset": 25486,
          "referenceAllele": "G",
          "start": 935,
          "startIntronDirection": "+",
          "startIntronOffset": 25485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003821",
      "geneNCBI_id": 2309,
      "geneSymbol": "FOXO3",
      "hgvs": [
        "NM_201559.3:c.621+25486G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_963853.1:n.621+25486G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701570"
    }
  ],
  "type": "nucleotide"
}