{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA119050",
  "communityStandardTitle": [
    "NM_001372051.1(CASP8):c.1228_1229del (p.Val410PhefsTer28)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3355742",
        "active": true,
        "id": "COSM3355742"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3718876",
        "active": true,
        "id": "COSM3718876"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3718877",
        "active": true,
        "id": "COSM3718877"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=22800[alleleid]",
        "alleleId": 22800,
        "preferredName": "NM_001372051.1(CASP8):c.1228_1229del (p.Val410fs)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/7761",
        "RCV": [
          "RCV000008202"
        ],
        "variationId": 7761
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr2:g.202149964_202149965del?assembly=hg19",
        "id": "chr2:g.202149964_202149965del"
      },
      {
        "@id": "http://myvariant.info/v1/variant/chr2:g.202149961_202149962del?assembly=hg19",
        "id": "chr2:g.202149961_202149962del"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr2:g.201285241_201285242del?assembly=hg38",
        "id": "chr2:g.201285241_201285242del"
      },
      {
        "@id": "http://myvariant.info/v1/variant/chr2:g.201285238_201285239del?assembly=hg38",
        "id": "chr2:g.201285238_201285239del"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/587776665",
        "rs": 587776665
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/2-201285237-CTG-C?dataset=gnomad_r3",
        "id": "2-201285237-CTG-C",
        "variant": "2:201285237 CTG / C"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/2-201285237-CTG-C?dataset=gnomad_r4",
        "id": "2-201285237-CTG-C",
        "variant": "2:201285237 CTG / C"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "2",
      "coordinates": [
        {
          "allele": "",
          "end": 201285242,
          "referenceAllele": "GT",
          "start": 201285240
        }
      ],
      "hgvs": [
        "NC_000002.12:g.201285241_201285242del",
        "CM000664.2:g.201285241_201285242del"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000050"
    },
    {
      "chromosome": "2",
      "coordinates": [
        {
          "allele": "",
          "end": 202149965,
          "referenceAllele": "GT",
          "start": 202149963
        }
      ],
      "hgvs": [
        "NC_000002.11:g.202149964_202149965del",
        "CM000664.1:g.202149964_202149965del"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000026"
    },
    {
      "chromosome": "2",
      "coordinates": [
        {
          "allele": "",
          "end": 201858210,
          "referenceAllele": "GT",
          "start": 201858208
        }
      ],
      "hgvs": [
        "NC_000002.10:g.201858209_201858210del"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000002"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 56785,
          "referenceAllele": "GT",
          "start": 56783
        }
      ],
      "hgvs": [
        "NG_007497.1:g.56784_56785del",
        "LRG_34:g.56784_56785del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000619"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1375,
          "referenceAllele": "GT",
          "start": 1373
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000413726.6:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000397528.2:p.Val410PhefsTer28",
        "hgvsWellDefined": "ENSP00000397528.2:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS904704"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1447,
          "referenceAllele": "GT",
          "start": 1445
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000440732.6:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000396869.2:p.Val410PhefsTer28",
        "hgvsWellDefined": "ENSP00000396869.2:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS904915"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 977,
          "referenceAllele": "GT",
          "start": 975
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000444430.3:c.976_977del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000394434.3:p.Val326PhefsTer28",
        "hgvsWellDefined": "ENSP00000394434.3:p.[Val326_Asn330delinsPheLeuProLys;Ala332_Glu333delinsCysArg;Thr335_Arg346delinsAsnLeuValHisProValThrLeuProGluPro;Cys349_Ile355delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS904938"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1113,
          "referenceAllele": "GT",
          "start": 1111
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000450491.6:c.874_875del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391709.2:p.Val292PhefsTer28",
        "hgvsWellDefined": "ENSP00000391709.2:p.[Val292_Asn296delinsPheLeuProLys;Ala298_Glu299delinsCysArg;Thr301_Arg312delinsAsnLeuValHisProValThrLeuProGluPro;Cys315_Ile321delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS904994"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1509,
          "referenceAllele": "GT",
          "start": 1507
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000696067.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512369.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "ENSP00000512369.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS907544"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1219,
          "referenceAllele": "GT",
          "start": 1217
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000696068.1:c.*455_*456del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512370.1:n.*455_*456del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS907545"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1184,
          "referenceAllele": "GT",
          "start": 1182
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000696069.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512371.1:p.Val395PhefsTer?",
        "hgvsWellDefined": "ENSP00000512371.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Ser409delinsAsnLeuValHisProValThr;Cys411_Leu414delinsProGluProGlu;Glu416_Thr424delinsAlaMetSerSerValPheAlaTyrArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS907546"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1483,
          "referenceAllele": "GT",
          "start": 1481
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000696085.1:c.1360_1361del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512381.1:p.Val454PhefsTer28",
        "hgvsWellDefined": "ENSP00000512381.1:p.[Val454_Asn458delinsPheLeuProLys;Ala460_Glu461delinsCysArg;Thr463_Arg474delinsAsnLeuValHisProValThrLeuProGluPro;Cys477_Ile483delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS907562"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 503,
          "referenceAllele": "GT",
          "start": 501
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000696086.1:n.502_503del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS907563"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1314,
          "referenceAllele": "GT",
          "start": 1312
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000696087.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000512382.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "ENSP00000512382.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS907564"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1333,
          "referenceAllele": "GT",
          "start": 1331
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000673742.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501268.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "ENSP00000501268.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773834",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000673742.1:c.1228_1229del"
          },
          "RefSeq": {
            "hgvs": "NM_001372051.1:c.1228_1229del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000501268.1:p.Val410PhefsTer28"
          },
          "RefSeq": {
            "hgvs": "NP_001358980.1:p.Val410PhefsTer28"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1212,
          "referenceAllele": "GT",
          "start": 1210
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000264274.13:c.976_977del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000264274.9:p.Val326PhefsTer28",
        "hgvsWellDefined": "ENSP00000264274.9:p.[Val326_Asn330delinsPheLeuProLys;Ala332_Glu333delinsCysArg;Thr335_Arg346delinsAsnLeuValHisProValThrLeuProGluPro;Cys349_Ile355delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS251469"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1560,
          "referenceAllele": "GT",
          "start": 1558
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000264275.9:c.1279_1280del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000264275.5:p.Val427PhefsTer28",
        "hgvsWellDefined": "ENSP00000264275.5:p.[Val427_Asn431delinsPheLeuProLys;Ala433_Glu434delinsCysArg;Thr436_Arg447delinsAsnLeuValHisProValThrLeuProGluPro;Cys450_Ile456delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS251470"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1324,
          "referenceAllele": "GT",
          "start": 1322
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000323492.11:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000325722.7:p.Val395PhefsTer28",
        "hgvsWellDefined": "ENSP00000325722.7:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS258218"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1450,
          "referenceAllele": "GT",
          "start": 1448
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000339403.6:n.1449_1450del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS260856"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1602,
          "referenceAllele": "GT",
          "start": 1600
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000358485.8:c.1405_1406del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000351273.4:p.Val469PhefsTer28",
        "hgvsWellDefined": "ENSP00000351273.4:p.[Val469_Asn473delinsPheLeuProLys;Ala475_Glu476delinsCysArg;Thr478_Arg489delinsAsnLeuValHisProValThrLeuProGluPro;Cys492_Ile498delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS264467"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1419,
          "referenceAllele": "GT",
          "start": 1417
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000392263.6:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000376091.2:p.Val395PhefsTer28",
        "hgvsWellDefined": "ENSP00000376091.2:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS275004"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1418,
          "referenceAllele": "GT",
          "start": 1416
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000432109.6:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000412523.2:p.Val410PhefsTer28",
        "hgvsWellDefined": "ENSP00000412523.2:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS291945"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 566,
          "referenceAllele": "GT",
          "start": 564
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "ENST00000444430.2:c.565_566del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000394434.2:p.Val189PhefsTer28",
        "hgvsWellDefined": "ENSP00000394434.2:p.[Val189_Asn193delinsPheLeuProLys;Ala195_Glu196delinsCysArg;Thr198_Arg209delinsAsnLeuValHisProValThrLeuProGluPro;Cys212_Ile218delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS297806"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1419,
          "referenceAllele": "GT",
          "start": 1417
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001080124.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001073593.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001073593.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS010142"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1607,
          "referenceAllele": "GT",
          "start": 1605
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001080125.1:c.1405_1406del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001073594.1:p.Val469PhefsTer28",
        "hgvsWellDefined": "NP_001073594.1:p.[Val469_Asn473delinsPheLeuProLys;Ala475_Glu476delinsCysArg;Thr478_Arg489delinsAsnLeuValHisProValThrLeuProGluPro;Cys492_Ile498delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS010143"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1583,
          "referenceAllele": "GT",
          "start": 1581
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001228.4:c.1279_1280del",
        "LRG_34t1:c.1279_1280del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001219.2:p.Val427PhefsTer28",
        "hgvsWellDefined": "NP_001219.2:p.[Val427_Asn431delinsPheLeuProLys;Ala433_Glu434delinsCysArg;Thr436_Arg447delinsAsnLeuValHisProValThrLeuProGluPro;Cys450_Ile456delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS018044"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1438,
          "referenceAllele": "GT",
          "start": 1436
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_033355.3:c.1228_1229del",
        "LRG_34t2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_203519.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_203519.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS039695"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1324,
          "referenceAllele": "GT",
          "start": 1322
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_033356.3:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_203520.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_203520.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS039696"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1743,
          "referenceAllele": "GT",
          "start": 1741
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_111983.1:n.1742_1743del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS055171"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1382,
          "referenceAllele": "GT",
          "start": 1380
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246885.1:c.1360_1361del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246942.1:p.Val454PhefsTer28",
        "hgvsWellDefined": "XP_005246942.1:p.[Val454_Asn458delinsPheLeuProLys;Ala460_Glu461delinsCysArg;Thr463_Arg474delinsAsnLeuValHisProValThrLeuProGluPro;Cys477_Ile483delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057824"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1353,
          "referenceAllele": "GT",
          "start": 1351
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246886.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246943.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246943.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057825"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1505,
          "referenceAllele": "GT",
          "start": 1503
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246887.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246944.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246944.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057826"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1447,
          "referenceAllele": "GT",
          "start": 1445
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246888.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246945.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246945.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057827"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1324,
          "referenceAllele": "GT",
          "start": 1322
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246889.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246946.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246946.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057828"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1325,
          "referenceAllele": "GT",
          "start": 1323
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246890.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246947.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246947.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057829"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1568,
          "referenceAllele": "GT",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246891.3:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246948.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246948.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057830"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1279,
          "referenceAllele": "GT",
          "start": 1277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246892.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246949.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "XP_005246949.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057831"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1436,
          "referenceAllele": "GT",
          "start": 1434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246894.2:c.631_632del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246951.1:p.Val211PhefsTer28",
        "hgvsWellDefined": "XP_005246951.1:p.[Val211_Asn215delinsPheLeuProLys;Ala217_Glu218delinsCysArg;Thr220_Arg231delinsAsnLeuValHisProValThrLeuProGluPro;Cys234_Ile240delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS057833"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1464,
          "referenceAllele": "GT",
          "start": 1462
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_006712789.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_006712852.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_006712852.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS069830"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1340,
          "referenceAllele": "GT",
          "start": 1338
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_006712790.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_006712853.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_006712853.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS069831"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1175,
          "referenceAllele": "GT",
          "start": 1173
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_006712791.1:c.1153_1154del"
      ],
      "proteinEffect": {
        "hgvs": "XP_006712854.1:p.Val385PhefsTer28",
        "hgvsWellDefined": "XP_006712854.1:p.[Val385_Asn389delinsPheLeuProLys;Ala391_Glu392delinsCysArg;Thr394_Arg405delinsAsnLeuValHisProValThrLeuProGluPro;Cys408_Ile414delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS069832"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 908,
          "referenceAllele": "GT",
          "start": 906
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_011511969.1:c.793_794del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011510271.1:p.Val265PhefsTer28",
        "hgvsWellDefined": "XP_011510271.1:p.[Val265_Asn269delinsPheLeuProLys;Ala271_Glu272delinsCysArg;Thr274_Arg285delinsAsnLeuValHisProValThrLeuProGluPro;Cys288_Ile294delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS079228"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1382,
          "referenceAllele": "GT",
          "start": 1380
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246885.2:c.1360_1361del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246942.1:p.Val454PhefsTer28",
        "hgvsWellDefined": "XP_005246942.1:p.[Val454_Asn458delinsPheLeuProLys;Ala460_Glu461delinsCysArg;Thr463_Arg474delinsAsnLeuValHisProValThrLeuProGluPro;Cys477_Ile483delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532715"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1353,
          "referenceAllele": "GT",
          "start": 1351
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246886.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246943.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246943.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532716"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1505,
          "referenceAllele": "GT",
          "start": 1503
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246887.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246944.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246944.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532717"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1447,
          "referenceAllele": "GT",
          "start": 1445
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246888.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246945.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246945.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532718"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1324,
          "referenceAllele": "GT",
          "start": 1322
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246889.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246946.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246946.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532719"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1331,
          "referenceAllele": "GT",
          "start": 1329
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246890.4:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246947.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246947.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532720"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1571,
          "referenceAllele": "GT",
          "start": 1569
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246891.5:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246948.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_005246948.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532721"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1279,
          "referenceAllele": "GT",
          "start": 1277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246892.2:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246949.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "XP_005246949.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532722"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1404,
          "referenceAllele": "GT",
          "start": 1402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_005246894.4:c.631_632del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005246951.1:p.Val211PhefsTer28",
        "hgvsWellDefined": "XP_005246951.1:p.[Val211_Asn215delinsPheLeuProLys;Ala217_Glu218delinsCysArg;Thr220_Arg231delinsAsnLeuValHisProValThrLeuProGluPro;Cys234_Ile240delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS532724"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1464,
          "referenceAllele": "GT",
          "start": 1462
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_006712789.2:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_006712852.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_006712852.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS538347"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1343,
          "referenceAllele": "GT",
          "start": 1341
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_006712790.4:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "XP_006712853.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "XP_006712853.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS538348"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 908,
          "referenceAllele": "GT",
          "start": 906
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "XM_011511969.2:c.793_794del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011510271.1:p.Val265PhefsTer28",
        "hgvsWellDefined": "XP_011510271.1:p.[Val265_Asn269delinsPheLeuProLys;Ala271_Glu272delinsCysArg;Thr274_Arg285delinsAsnLeuValHisProValThrLeuProGluPro;Cys288_Ile294delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS542364"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1399,
          "referenceAllele": "GT",
          "start": 1397
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001080124.2:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001073593.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001073593.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676242"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1603,
          "referenceAllele": "GT",
          "start": 1601
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001080125.2:c.1405_1406del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001073594.1:p.Val469PhefsTer28",
        "hgvsWellDefined": "NP_001073594.1:p.[Val469_Asn473delinsPheLeuProLys;Ala475_Glu476delinsCysArg;Thr478_Arg489delinsAsnLeuValHisProValThrLeuProGluPro;Cys492_Ile498delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676243"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1333,
          "referenceAllele": "GT",
          "start": 1331
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001372051.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001358980.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001358980.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693114",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000673742.1:c.1228_1229del"
          },
          "RefSeq": {
            "hgvs": "NM_001372051.1:c.1228_1229del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000501268.1:p.Val410PhefsTer28"
          },
          "RefSeq": {
            "hgvs": "NP_001358980.1:p.Val410PhefsTer28"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1288,
          "referenceAllele": "GT",
          "start": 1286
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_033356.4:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_203520.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_203520.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699340"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1739,
          "referenceAllele": "GT",
          "start": 1737
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_111983.2:n.1738_1739del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS703185"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1558,
          "referenceAllele": "GT",
          "start": 1556
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400642.1:c.1360_1361del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387571.1:p.Val454PhefsTer28",
        "hgvsWellDefined": "NP_001387571.1:p.[Val454_Asn458delinsPheLeuProLys;Ala460_Glu461delinsCysArg;Thr463_Arg474delinsAsnLeuValHisProValThrLeuProGluPro;Cys477_Ile483delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783904"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1408,
          "referenceAllele": "GT",
          "start": 1406
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400645.1:c.1261_1262del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387574.1:p.Val421PhefsTer28",
        "hgvsWellDefined": "NP_001387574.1:p.[Val421_Asn425delinsPheLeuProLys;Ala427_Glu428delinsCysArg;Thr430_Arg441delinsAsnLeuValHisProValThrLeuProGluPro;Cys444_Ile450delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783907"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1444,
          "referenceAllele": "GT",
          "start": 1442
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400648.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387577.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387577.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783910"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1512,
          "referenceAllele": "GT",
          "start": 1510
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400651.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387580.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387580.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783913"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1307,
          "referenceAllele": "GT",
          "start": 1305
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400653.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387582.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387582.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783915"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1349,
          "referenceAllele": "GT",
          "start": 1347
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400654.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387583.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387583.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783916"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1577,
          "referenceAllele": "GT",
          "start": 1575
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400655.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387584.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387584.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783917"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1375,
          "referenceAllele": "GT",
          "start": 1373
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400656.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387585.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387585.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783918"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1486,
          "referenceAllele": "GT",
          "start": 1484
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400657.1:c.1228_1229del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387586.1:p.Val410PhefsTer28",
        "hgvsWellDefined": "NP_001387586.1:p.[Val410_Asn414delinsPheLeuProLys;Ala416_Glu417delinsCysArg;Thr419_Arg430delinsAsnLeuValHisProValThrLeuProGluPro;Cys433_Ile439delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783919"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1330,
          "referenceAllele": "GT",
          "start": 1328
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400658.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387587.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001387587.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783920"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1262,
          "referenceAllele": "GT",
          "start": 1260
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400659.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387588.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001387588.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783921"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1441,
          "referenceAllele": "GT",
          "start": 1439
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400660.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387589.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001387589.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783922"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1373,
          "referenceAllele": "GT",
          "start": 1371
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400661.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387590.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001387590.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783923"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1532,
          "referenceAllele": "GT",
          "start": 1530
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400662.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387591.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001387591.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783924"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1467,
          "referenceAllele": "GT",
          "start": 1465
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400663.1:c.1183_1184del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387592.1:p.Val395PhefsTer28",
        "hgvsWellDefined": "NP_001387592.1:p.[Val395_Asn399delinsPheLeuProLys;Ala401_Glu402delinsCysArg;Thr404_Arg415delinsAsnLeuValHisProValThrLeuProGluPro;Cys418_Ile424delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783925"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1264,
          "referenceAllele": "GT",
          "start": 1262
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400664.1:c.1159_1160del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387593.1:p.Val387PhefsTer28",
        "hgvsWellDefined": "NP_001387593.1:p.[Val387_Asn391delinsPheLeuProLys;Ala393_Glu394delinsCysArg;Thr396_Arg407delinsAsnLeuValHisProValThrLeuProGluPro;Cys410_Ile416delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783926"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1351,
          "referenceAllele": "GT",
          "start": 1349
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400665.1:c.1153_1154del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387594.1:p.Val385PhefsTer28",
        "hgvsWellDefined": "NP_001387594.1:p.[Val385_Asn389delinsPheLeuProLys;Ala391_Glu392delinsCysArg;Thr394_Arg405delinsAsnLeuValHisProValThrLeuProGluPro;Cys408_Ile414delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783927"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1126,
          "referenceAllele": "GT",
          "start": 1124
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400666.1:c.1021_1022del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387595.1:p.Val341PhefsTer28",
        "hgvsWellDefined": "NP_001387595.1:p.[Val341_Asn345delinsPheLeuProLys;Ala347_Glu348delinsCysArg;Thr350_Arg361delinsAsnLeuValHisProValThrLeuProGluPro;Cys364_Ile370delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783928"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1081,
          "referenceAllele": "GT",
          "start": 1079
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400667.1:c.976_977del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387596.1:p.Val326PhefsTer28",
        "hgvsWellDefined": "NP_001387596.1:p.[Val326_Asn330delinsPheLeuProLys;Ala332_Glu333delinsCysArg;Thr335_Arg346delinsAsnLeuValHisProValThrLeuProGluPro;Cys349_Ile355delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783929"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1123,
          "referenceAllele": "GT",
          "start": 1121
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400668.1:c.976_977del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387597.1:p.Val326PhefsTer28",
        "hgvsWellDefined": "NP_001387597.1:p.[Val326_Asn330delinsPheLeuProLys;Ala332_Glu333delinsCysArg;Thr335_Arg346delinsAsnLeuValHisProValThrLeuProGluPro;Cys349_Ile355delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783930"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1181,
          "referenceAllele": "GT",
          "start": 1179
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400669.1:c.919_920del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387598.1:p.Val307PhefsTer28",
        "hgvsWellDefined": "NP_001387598.1:p.[Val307_Asn311delinsPheLeuProLys;Ala313_Glu314delinsCysArg;Thr316_Arg327delinsAsnLeuValHisProValThrLeuProGluPro;Cys330_Ile336delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783931"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 906,
          "endIntronDirection": "-",
          "endIntronOffset": 20,
          "referenceAllele": "GT",
          "start": 906,
          "startIntronDirection": "-",
          "startIntronOffset": 22
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400670.1:c.803-22_803-21del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387599.1:n.803-22_803-21del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783932"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1268,
          "referenceAllele": "GT",
          "start": 1266
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400671.1:c.631_632del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387600.1:p.Val211PhefsTer28",
        "hgvsWellDefined": "NP_001387600.1:p.[Val211_Asn215delinsPheLeuProLys;Ala217_Glu218delinsCysArg;Thr220_Arg231delinsAsnLeuValHisProValThrLeuProGluPro;Cys234_Ile240delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783933"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 937,
          "referenceAllele": "GT",
          "start": 935
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400672.1:c.631_632del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387601.1:p.Val211PhefsTer28",
        "hgvsWellDefined": "NP_001387601.1:p.[Val211_Asn215delinsPheLeuProLys;Ala217_Glu218delinsCysArg;Thr220_Arg231delinsAsnLeuValHisProValThrLeuProGluPro;Cys234_Ile240delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783934"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1242,
          "referenceAllele": "GT",
          "start": 1240
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400673.1:c.631_632del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387602.1:p.Val211PhefsTer28",
        "hgvsWellDefined": "NP_001387602.1:p.[Val211_Asn215delinsPheLeuProLys;Ala217_Glu218delinsCysArg;Thr220_Arg231delinsAsnLeuValHisProValThrLeuProGluPro;Cys234_Ile240delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783935"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1431,
          "referenceAllele": "GT",
          "start": 1429
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400674.1:c.613_614del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387603.1:p.Val205PhefsTer28",
        "hgvsWellDefined": "NP_001387603.1:p.[Val205_Asn209delinsPheLeuProLys;Ala211_Glu212delinsCysArg;Thr214_Arg225delinsAsnLeuValHisProValThrLeuProGluPro;Cys228_Ile234delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783936"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 892,
          "referenceAllele": "GT",
          "start": 890
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400675.1:c.586_587del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387604.1:p.Val196PhefsTer28",
        "hgvsWellDefined": "NP_001387604.1:p.[Val196_Asn200delinsPheLeuProLys;Ala202_Glu203delinsCysArg;Thr205_Arg216delinsAsnLeuValHisProValThrLeuProGluPro;Cys219_Ile225delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783937"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1223,
          "referenceAllele": "GT",
          "start": 1221
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400676.1:c.586_587del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387605.1:p.Val196PhefsTer28",
        "hgvsWellDefined": "NP_001387605.1:p.[Val196_Asn200delinsPheLeuProLys;Ala202_Glu203delinsCysArg;Thr205_Arg216delinsAsnLeuValHisProValThrLeuProGluPro;Cys219_Ile225delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783938"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1376,
          "referenceAllele": "GT",
          "start": 1374
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400677.1:c.586_587del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387606.1:p.Val196PhefsTer28",
        "hgvsWellDefined": "NP_001387606.1:p.[Val196_Asn200delinsPheLeuProLys;Ala202_Glu203delinsCysArg;Thr205_Arg216delinsAsnLeuValHisProValThrLeuProGluPro;Cys219_Ile225delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783939"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1265,
          "referenceAllele": "GT",
          "start": 1263
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400678.1:c.586_587del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387607.1:p.Val196PhefsTer28",
        "hgvsWellDefined": "NP_001387607.1:p.[Val196_Asn200delinsPheLeuProLys;Ala202_Glu203delinsCysArg;Thr205_Arg216delinsAsnLeuValHisProValThrLeuProGluPro;Cys219_Ile225delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783940"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1440,
          "referenceAllele": "GT",
          "start": 1438
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400680.1:c.613_614del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387609.1:p.Val205PhefsTer28",
        "hgvsWellDefined": "NP_001387609.1:p.[Val205_Asn209delinsPheLeuProLys;Ala211_Glu212delinsCysArg;Thr214_Arg225delinsAsnLeuValHisProValThrLeuProGluPro;Cys228_Ile234delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS783942"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1512,
          "referenceAllele": "GT",
          "start": 1510
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400750.1:c.631_632del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387679.1:p.Val211PhefsTer28",
        "hgvsWellDefined": "NP_001387679.1:p.[Val211_Asn215delinsPheLeuProLys;Ala217_Glu218delinsCysArg;Thr220_Arg231delinsAsnLeuValHisProValThrLeuProGluPro;Cys234_Ile240delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS784009"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1467,
          "referenceAllele": "GT",
          "start": 1465
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NM_001400751.1:c.586_587del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001387680.1:p.Val196PhefsTer28",
        "hgvsWellDefined": "NP_001387680.1:p.[Val196_Asn200delinsPheLeuProLys;Ala202_Glu203delinsCysArg;Thr205_Arg216delinsAsnLeuValHisProValThrLeuProGluPro;Cys219_Ile225delinsAlaMetSerSerArgArg]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS784010"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1318,
          "referenceAllele": "GT",
          "start": 1316
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174564.1:n.1317_1318del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785003"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1448,
          "referenceAllele": "GT",
          "start": 1446
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174565.1:n.1447_1448del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785004"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1474,
          "referenceAllele": "GT",
          "start": 1472
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174581.1:n.1473_1474del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785019"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1580,
          "referenceAllele": "GT",
          "start": 1578
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174583.1:n.1579_1580del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785021"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1493,
          "referenceAllele": "GT",
          "start": 1491
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174584.1:n.1492_1493del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785022"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1511,
          "referenceAllele": "GT",
          "start": 1509
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174585.1:n.1510_1511del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785023"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1485,
          "referenceAllele": "GT",
          "start": 1483
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174586.1:n.1484_1485del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785024"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1648,
          "referenceAllele": "GT",
          "start": 1646
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174588.1:n.1647_1648del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785025"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1443,
          "referenceAllele": "GT",
          "start": 1441
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174589.1:n.1442_1443del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785026"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1535,
          "referenceAllele": "GT",
          "start": 1533
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174590.1:n.1534_1535del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785027"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1466,
          "referenceAllele": "GT",
          "start": 1464
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174591.1:n.1465_1466del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785028"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1811,
          "referenceAllele": "GT",
          "start": 1809
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174592.1:n.1810_1811del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785029"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1609,
          "referenceAllele": "GT",
          "start": 1607
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174593.1:n.1608_1609del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785030"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1652,
          "referenceAllele": "GT",
          "start": 1650
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174594.1:n.1651_1652del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785031"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1567,
          "referenceAllele": "GT",
          "start": 1565
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174595.1:n.1566_1567del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785032"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1404,
          "referenceAllele": "GT",
          "start": 1402
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174596.1:n.1403_1404del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785033"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1762,
          "referenceAllele": "GT",
          "start": 1760
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174598.1:n.1761_1762del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785034"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1146,
          "referenceAllele": "GT",
          "start": 1144
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174599.1:n.1145_1146del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785035"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1674,
          "referenceAllele": "GT",
          "start": 1672
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174600.1:n.1673_1674del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785036"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1599,
          "referenceAllele": "GT",
          "start": 1597
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174601.1:n.1598_1599del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785037"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1469,
          "referenceAllele": "GT",
          "start": 1467
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001509",
      "geneNCBI_id": 841,
      "geneSymbol": "CASP8",
      "hgvs": [
        "NR_174602.1:n.1468_1469del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS785038"
    }
  ],
  "type": "nucleotide"
}