{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1182937545",
  "communityStandardTitle": [
    "NM_000110.4(DPYD):c.851-1G="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057516696",
        "rs": 1057516696
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "1",
      "coordinates": [
        {
          "allele": "C",
          "end": 97595167,
          "referenceAllele": "C",
          "start": 97595166
        }
      ],
      "hgvs": [
        "NC_000001.11:g.97595167C=",
        "CM000663.2:g.97595167C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000049"
    },
    {
      "chromosome": "1",
      "coordinates": [
        {
          "allele": "C",
          "end": 98060723,
          "referenceAllele": "C",
          "start": 98060722
        }
      ],
      "hgvs": [
        "NC_000001.10:g.98060723C=",
        "CM000663.1:g.98060723C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000025"
    },
    {
      "chromosome": "1",
      "coordinates": [
        {
          "allele": "C",
          "end": 97833311,
          "referenceAllele": "C",
          "start": 97833310
        }
      ],
      "hgvs": [
        "NC_000001.9:g.97833311C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000001"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 330893,
          "referenceAllele": "G",
          "start": 330892
        }
      ],
      "hgvs": [
        "NG_008807.2:g.330893G=",
        "LRG_722:g.330893G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001226"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 962,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 962,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "ENST00000370192.8:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000359211.3:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS750558",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000370192.8:c.851-1G="
          },
          "RefSeq": {
            "hgvs": "NM_000110.4:c.851-1G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000359211.3:n.851-1G="
          },
          "RefSeq": {
            "hgvs": "NP_000101.2:n.851-1G="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 951,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 951,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "ENST00000370192.7:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000359211.3:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267925"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 987,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 987,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "NM_000110.3:c.851-1G=",
        "LRG_722t1:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000101.2:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006173"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 987,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 987,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_005270562.3:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005270619.2:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS066568"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 987,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 987,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_006710397.2:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_006710460.1:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS068587"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 987,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 987,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_006710397.3:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_006710460.1:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS537767"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 870,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 870,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_017000507.1:c.740-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016855996.1:n.740-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556868"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1140,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 1140,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_017000508.2:c.356-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016855997.1:n.356-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556869"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1039,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 1039,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_017000509.2:c.356-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016855998.1:n.356-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556870"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 984,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 984,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "XM_017000510.1:c.356-1G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016855999.1:n.356-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556871"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 962,
          "endIntronDirection": "-",
          "endIntronOffset": 0,
          "referenceAllele": "G",
          "start": 962,
          "startIntronDirection": "-",
          "startIntronOffset": 1
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003012",
      "geneNCBI_id": 1806,
      "geneSymbol": "DPYD",
      "hgvs": [
        "NM_000110.4:c.851-1G="
      ],
      "proteinEffect": {
        "hgvs": "NP_000101.2:n.851-1G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674705",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000370192.8:c.851-1G="
          },
          "RefSeq": {
            "hgvs": "NM_000110.4:c.851-1G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000359211.3:n.851-1G="
          },
          "RefSeq": {
            "hgvs": "NP_000101.2:n.851-1G="
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}