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          "referenceAllele": "A",
          "start": 1963
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006547",
      "geneNCBI_id": 3949,
      "geneSymbol": "LDLR",
      "hgvs": [
        "NM_001195798.2:c.1878del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001182727.1:p.Ala627ProfsTer?",
        "hgvsWellDefined": "NP_001182727.1:p.[Ala627_Ile628delinsPro;Ala631_Leu634delinsValPro;Gly636Ala;Asp638Gln;Asn640_Asn645delinsProMetSerThrCysTrp;Leu647_Leu654delinsLysThrTyrCysProGlnArgIleTrp;His656delinsSerSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679343"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1841,
          "referenceAllele": "A",
          "start": 1840
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006547",
      "geneNCBI_id": 3949,
      "geneSymbol": "LDLR",
      "hgvs": [
        "NM_001195799.2:c.1755del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001182728.1:p.Ala586ProfsTer?",
        "hgvsWellDefined": "NP_001182728.1:p.[Ala586_Ile587delinsPro;Ala590_Leu593delinsValPro;Gly595Ala;Asp597Gln;Asn599_Asn604delinsProMetSerThrCysTrp;Leu606_Leu613delinsLysThrTyrCysProGlnArgIleTrp;His615delinsSerSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679344"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1460,
          "referenceAllele": "A",
          "start": 1459
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006547",
      "geneNCBI_id": 3949,
      "geneSymbol": "LDLR",
      "hgvs": [
        "NM_001195800.2:c.1374del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001182729.1:p.Ala459ProfsTer?",
        "hgvsWellDefined": "NP_001182729.1:p.[Ala459_Ile460delinsPro;Ala463_Leu466delinsValPro;Gly468Ala;Asp470Gln;Asn472_Asn477delinsProMetSerThrCysTrp;Leu479_Leu486delinsLysThrTyrCysProGlnArgIleTrp;His488delinsSerSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679345"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1583,
          "referenceAllele": "A",
          "start": 1582
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006547",
      "geneNCBI_id": 3949,
      "geneSymbol": "LDLR",
      "hgvs": [
        "NM_001195803.2:c.1497del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001182732.1:p.Ala500ProfsTer?",
        "hgvsWellDefined": "NP_001182732.1:p.[Ala500_Ile501delinsPro;Ala504_Leu507delinsValPro;Gly509Ala;Asp511Gln;Asn513_Asn518delinsProMetSerThrCysTrp;Leu520_Leu527delinsLysThrTyrCysProGlnArgIleTrp;His529delinsSerSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679346"
    }
  ],
  "type": "nucleotide"
}