{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA10436708",
  "communityStandardTitle": [
    "NM_000044.6(AR):c.2659A>G (p.Met887Val)"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=265169[alleleid]",
        "alleleId": 265169,
        "preferredName": "NM_000044.6(AR):c.2659A>G (p.Met887Val)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/279689",
        "RCV": [
          "RCV000399756",
          "RCV000623126",
          "RCV001518328",
          "RCV003330619"
        ],
        "variationId": 279689
      }
    ],
    "ExAC": [
      {
        "@id": "http://exac.broadinstitute.org/variant/X-66943579-A-G",
        "id": "X-66943579-A-G",
        "variant": "X:66943579 A / G"
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chrX:g.66943579A>G?assembly=hg19",
        "id": "chrX:g.66943579A>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chrX:g.67723737A>G?assembly=hg38",
        "id": "chrX:g.67723737A>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/755226547",
        "rs": 755226547
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/X-66943579-A-G?dataset=gnomad_r2_1",
        "id": "X-66943579-A-G",
        "variant": "X:66943579 A / G"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/X-67723737-A-G?dataset=gnomad_r3",
        "id": "X-67723737-A-G",
        "variant": "X:67723737 A / G"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/X-67723737-A-G?dataset=gnomad_r4",
        "id": "X-67723737-A-G",
        "variant": "X:67723737 A / G"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "X",
      "coordinates": [
        {
          "allele": "G",
          "end": 67723737,
          "referenceAllele": "A",
          "start": 67723736
        }
      ],
      "hgvs": [
        "NC_000023.11:g.67723737A>G",
        "CM000685.2:g.67723737A>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000071"
    },
    {
      "chromosome": "X",
      "coordinates": [
        {
          "allele": "G",
          "end": 66943579,
          "referenceAllele": "A",
          "start": 66943578
        }
      ],
      "hgvs": [
        "NC_000023.10:g.66943579A>G",
        "CM000685.1:g.66943579A>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000047"
    },
    {
      "chromosome": "X",
      "coordinates": [
        {
          "allele": "G",
          "end": 66860304,
          "referenceAllele": "A",
          "start": 66860303
        }
      ],
      "hgvs": [
        "NC_000023.9:g.66860304A>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000023"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 184706,
          "referenceAllele": "A",
          "start": 184705
        }
      ],
      "hgvs": [
        "NG_009014.2:g.184706A>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001379"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 3972,
          "referenceAllele": "A",
          "start": 3971
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000396043.4:c.*1007A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000379358.4:n.*1007A>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914009"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 3785,
          "referenceAllele": "A",
          "start": 3784
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000374690.9:c.2659A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000363822.3:p.Met887Val",
        "hgvsWellDefined": "ENSP00000363822.3:p.Met887Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS751477",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000374690.9:c.2659A>G"
          },
          "RefSeq": {
            "hgvs": "NM_000044.6:c.2659A>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000363822.3:p.Met887Val"
          },
          "RefSeq": {
            "hgvs": "NP_000035.2:p.Met887Val"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1286,
          "referenceAllele": "A",
          "start": 1285
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000396043.3:c.1286A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000379358.3:n.1286A>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS753474"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2228,
          "referenceAllele": "A",
          "start": 2227
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000396044.8:c.*20A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000379359.3:n.*20A>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS753475"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 3785,
          "referenceAllele": "A",
          "start": 3784
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000612452.5:c.2659A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484033.2:p.Met887Val",
        "hgvsWellDefined": "ENSP00000484033.2:p.Met887Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS761876"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 3183,
          "referenceAllele": "A",
          "start": 3182
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000374690.7:c.2659A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000363822.3:p.Met887Val",
        "hgvsWellDefined": "ENSP00000363822.3:p.Met887Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS270362"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1177,
          "referenceAllele": "A",
          "start": 1176
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000396043.2:c.1063A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000379358.2:p.Met355Val",
        "hgvsWellDefined": "ENSP00000379358.2:p.Met355Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS277057"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 3340,
          "referenceAllele": "A",
          "start": 3339
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000396044.7:c.*20A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000379359.3:n.*20A>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS277058"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 3795,
          "referenceAllele": "A",
          "start": 3794
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "ENST00000612452.4:c.2110A>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484033.1:p.Met704Val",
        "hgvsWellDefined": "ENSP00000484033.1:p.Met704Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS401311"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645451518",
      "coordinates": [
        {
          "allele": "G",
          "end": 3774,
          "referenceAllele": "A",
          "start": 3773
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "NM_000044.3:c.2659A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000035.2:p.Met887Val",
        "hgvsWellDefined": "NP_000035.2:p.Met887Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006109"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825305720",
      "coordinates": [
        {
          "allele": "G",
          "end": 1225,
          "referenceAllele": "A",
          "start": 1224
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "NM_001011645.2:c.1063A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001011645.1:p.Met355Val",
        "hgvsWellDefined": "NP_001011645.1:p.Met355Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS008239"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645451518",
      "coordinates": [
        {
          "allele": "G",
          "end": 3183,
          "referenceAllele": "A",
          "start": 3182
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "NM_000044.4:c.2659A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000035.2:p.Met887Val",
        "hgvsWellDefined": "NP_000035.2:p.Met887Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS510743"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825305720",
      "coordinates": [
        {
          "allele": "G",
          "end": 3370,
          "referenceAllele": "A",
          "start": 3369
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "NM_001011645.3:c.1063A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001011645.1:p.Met355Val",
        "hgvsWellDefined": "NP_001011645.1:p.Met355Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511003"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645451518",
      "coordinates": [
        {
          "allele": "G",
          "end": 3785,
          "referenceAllele": "A",
          "start": 3784
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000644",
      "geneNCBI_id": 367,
      "geneSymbol": "AR",
      "hgvs": [
        "NM_000044.6:c.2659A>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000035.2:p.Met887Val",
        "hgvsWellDefined": "NP_000035.2:p.Met887Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674674",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000374690.9:c.2659A>G"
          },
          "RefSeq": {
            "hgvs": "NM_000044.6:c.2659A>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000363822.3:p.Met887Val"
          },
          "RefSeq": {
            "hgvs": "NP_000035.2:p.Met887Val"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}