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      "proteinEffect": {
        "hgvs": "NP_002993.1:p.Arg22Ter",
        "hgvsWellDefined": "NP_002993.1:p.Arg22_Leu159delinsThrProValValArgProAlaHisIleSerAlaPheLeuGlnAspArgProIleProGluTrpCysGlyValGlnHisIleHisLeuSerProSerHisHisSerGlySerLysAlaAlaSerLeuHisTrpThrSerGluArgValValSerValLeuLeuLeuGlyLeuLeuProAlaAlaTyrLeuAsnProCysSerAlaMetAspTyrSerLeuAlaAlaAlaLeuThrLeuHisGlyHisTrpGlyLeuGlyGlnValValThrAspTyrValHisGlyAspAlaLeuGlnLysAlaAlaLysAlaGlyLeuLeuAlaLeuSerAlaLeuThrPheAlaGlyLeuCysTyrPheAsnTyrHisAspValGlyIleCysLysAlaValAlaMetLeuTrpLysLeuTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS028283"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 148,
          "referenceAllele": "C",
          "start": 147
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010683",
      "geneNCBI_id": 6392,
      "geneSymbol": "SDHD",
      "hgvs": [
        "NR_077060.1:n.148C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS052741"
    },
    {
      "@id": "http://reg.genome.network/allele/PA253993",
      "coordinates": [
        {
          "allele": "T",
          "end": 99,
          "referenceAllele": "C",
          "start": 98
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010683",
      "geneNCBI_id": 6392,
      "geneSymbol": "SDHD",
      "hgvs": [
        "NM_003002.4:c.64C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_002993.1:p.Arg22Ter",
        "hgvsWellDefined": "NP_002993.1:p.Arg22_Leu159delinsThrProValValArgProAlaHisIleSerAlaPheLeuGlnAspArgProIleProGluTrpCysGlyValGlnHisIleHisLeuSerProSerHisHisSerGlySerLysAlaAlaSerLeuHisTrpThrSerGluArgValValSerValLeuLeuLeuGlyLeuLeuProAlaAlaTyrLeuAsnProCysSerAlaMetAspTyrSerLeuAlaAlaAlaLeuThrLeuHisGlyHisTrpGlyLeuGlyGlnValValThrAspTyrValHisGlyAspAlaLeuGlnLysAlaAlaLysAlaGlyLeuLeuAlaLeuSerAlaLeuThrPheAlaGlyLeuCysTyrPheAsnTyrHisAspValGlyIleCysLysAlaValAlaMetLeuTrpLysLeuTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS665822",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000375549.8:c.64C>T"
          },
          "RefSeq": {
            "hgvs": "NM_003002.4:c.64C>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000364699.3:p.Arg22Ter"
          },
          "RefSeq": {
            "hgvs": "NP_002993.1:p.Arg22Ter"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826558125",
      "coordinates": [
        {
          "allele": "T",
          "end": 99,
          "referenceAllele": "C",
          "start": 98
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010683",
      "geneNCBI_id": 6392,
      "geneSymbol": "SDHD",
      "hgvs": [
        "NM_001276503.2:c.64C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263432.1:p.Arg22Ter",
        "hgvsWellDefined": "NP_001263432.1:p.Arg22_Leu85delinsThrProValValArgProAlaHisIleSerAlaPheLeuGlnAspArgProIleProGluTrpCysGlyValGlnHisIleHisLeuSerProSerHisHisTrpAlaLeuAspLysLeuLeuLeuThrMetPheMetGlyMetProCysArgLysLeuProArgGlnGlyPheTrpHisPheGlnLeuTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681327"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 87,
          "endIntronDirection": "+",
          "endIntronOffset": 909,
          "referenceAllele": "C",
          "start": 87,
          "startIntronDirection": "+",
          "startIntronOffset": 908
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010683",
      "geneNCBI_id": 6392,
      "geneSymbol": "SDHD",
      "hgvs": [
        "NM_001276504.2:c.52+909C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263433.1:n.52+909C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681328"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826558661",
      "coordinates": [
        {
          "allele": "T",
          "end": 99,
          "referenceAllele": "C",
          "start": 98
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010683",
      "geneNCBI_id": 6392,
      "geneSymbol": "SDHD",
      "hgvs": [
        "NM_001276506.2:c.64C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263435.1:p.Arg22Ter",
        "hgvsWellDefined": "NP_001263435.1:p.Arg22_Lys143delinsThrProValValArgProAlaHisIleSerAlaPheLeuGlnAspArgProIleProGluTrpCysGlyValGlnHisIleHisLeuSerProSerHisHisSerGlySerLysAlaAlaSerLeuHisTrpThrSerGluArgValValSerValLeuLeuLeuGlyLeuLeuProAlaAlaTyrLeuAsnProCysSerAlaMetAspTyrSerLeuAlaAlaAlaLeuThrLeuHisGlyHisTrpLeuGluCysAsnGlyAlaIleLeuAlaArgHisAspLeuGlySerAlaArgSerGlnLeuThrAlaThrSerAlaPheArgValGlnAlaIleLeuLeuProGlnProProLysTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681329"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 99,
          "referenceAllele": "C",
          "start": 98
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010683",
      "geneNCBI_id": 6392,
      "geneSymbol": "SDHD",
      "hgvs": [
        "NR_077060.2:n.99C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS702805"
    }
  ],
  "type": "nucleotide"
}