{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA008436",
  "communityStandardTitle": [
    "NM_000038.6(APC):c.3472A>T (p.Arg1158Ter)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=4385836",
        "active": true,
        "id": "COSM4385836"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=132746[alleleid]",
        "alleleId": 132746,
        "preferredName": "NM_000038.6(APC):c.3472A>T (p.Arg1158Ter)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/127289",
        "RCV": [
          "RCV000115085",
          "RCV003278666",
          "RCV003335099"
        ],
        "variationId": 127289
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr5:g.112174763A>T?assembly=hg19",
        "id": "chr5:g.112174763A>T"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr5:g.112839066A>T?assembly=hg38",
        "id": "chr5:g.112839066A>T"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/587779790",
        "rs": 587779790
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "T",
          "end": 112839066,
          "referenceAllele": "A",
          "start": 112839065
        }
      ],
      "hgvs": [
        "NC_000005.10:g.112839066A>T",
        "CM000667.2:g.112839066A>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000053"
    },
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "T",
          "end": 112174763,
          "referenceAllele": "A",
          "start": 112174762
        }
      ],
      "hgvs": [
        "NC_000005.9:g.112174763A>T",
        "CM000667.1:g.112174763A>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000029"
    },
    {
      "chromosome": "5",
      "coordinates": [
        {
          "allele": "T",
          "end": 112202662,
          "referenceAllele": "A",
          "start": 112202661
        }
      ],
      "hgvs": [
        "NC_000005.8:g.112202662A>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000005"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 151546,
          "referenceAllele": "A",
          "start": 151545
        }
      ],
      "hgvs": [
        "NG_008481.4:g.151546A>T",
        "LRG_130:g.151546A>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001117"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3137,
          "referenceAllele": "A",
          "start": 3136
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000502371.3:c.3137A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484935.2:n.3137A>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914176"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3582,
          "referenceAllele": "A",
          "start": 3581
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000504915.3:c.3526A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473355.2:p.Arg1176Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914183"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3852,
          "referenceAllele": "A",
          "start": 3851
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000505350.2:c.*3478A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481752.1:n.*3478A>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914185"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3614,
          "referenceAllele": "A",
          "start": 3613
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000507379.6:c.3418A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423224.2:p.Arg1140Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914189"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3622,
          "referenceAllele": "A",
          "start": 3621
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000509732.6:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426541.2:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914195"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3823,
          "referenceAllele": "A",
          "start": 3822
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000512211.7:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423828.3:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914202"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3531,
          "referenceAllele": "A",
          "start": 3530
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000257430.9:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000257430.4:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS741831",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000257430.9:c.3472A>T"
          },
          "RefSeq": {
            "hgvs": "NM_000038.6:c.3472A>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000257430.4:p.Arg1158Ter"
          },
          "RefSeq": {
            "hgvs": "NP_000029.2:p.Arg1158Ter"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3528,
          "referenceAllele": "A",
          "start": 3527
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000257430.8:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000257430.4:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247400"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1825,
          "referenceAllele": "A",
          "start": 1824
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000502371.2:c.1825A>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS334951"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3629,
          "referenceAllele": "A",
          "start": 3628
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000508376.6:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000427089.2:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247198"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3717,
          "referenceAllele": "A",
          "start": 3716
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000508624.5:c.*2794A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424265.1:n.*2794A>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS339602"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3619,
          "referenceAllele": "A",
          "start": 3618
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "ENST00000512211.6:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423828.2:p.Arg1158Ter",
        "hgvsWellDefined": "ENSP00000423828.2:p.Arg1158_Ala1305del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247286"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 230,
          "endIntronDirection": "+",
          "endIntronOffset": 10094,
          "referenceAllele": "A",
          "start": 230,
          "startIntronDirection": "+",
          "startIntronOffset": 10093
        }
      ],
      "hgvs": [
        "ENST00000520401.1:c.230+10094A>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS347453"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3557,
          "referenceAllele": "A",
          "start": 3556
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_000038.5:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000029.2:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006103"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3665,
          "referenceAllele": "A",
          "start": 3664
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127510.2:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120982.1:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011634"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3631,
          "referenceAllele": "A",
          "start": 3630
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127511.2:c.3418A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120983.2:p.Arg1140Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011635"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3868,
          "referenceAllele": "A",
          "start": 3867
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354895.1:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341824.1:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522733"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3611,
          "referenceAllele": "A",
          "start": 3610
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354896.1:c.3526A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341825.1:p.Arg1176Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522734"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3715,
          "referenceAllele": "A",
          "start": 3714
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354897.1:c.3502A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341826.1:p.Arg1168Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522735"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3512,
          "referenceAllele": "A",
          "start": 3511
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354898.1:c.3397A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341827.1:p.Arg1133Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522736"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3473,
          "referenceAllele": "A",
          "start": 3472
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354899.1:c.3388A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341828.1:p.Arg1130Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522737"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3458,
          "referenceAllele": "A",
          "start": 3457
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354900.1:c.3349A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341829.1:p.Arg1117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522738"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3404,
          "referenceAllele": "A",
          "start": 3403
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354901.1:c.3295A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341830.1:p.Arg1099Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522739"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3412,
          "referenceAllele": "A",
          "start": 3411
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354902.1:c.3199A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341831.1:p.Arg1067Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522740"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3254,
          "referenceAllele": "A",
          "start": 3253
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354903.1:c.3169A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341832.1:p.Arg1057Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522741"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3209,
          "referenceAllele": "A",
          "start": 3208
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354904.1:c.3094A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341833.1:p.Arg1032Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522742"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3101,
          "referenceAllele": "A",
          "start": 3100
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354905.1:c.2992A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341834.1:p.Arg998Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522743"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3743,
          "referenceAllele": "A",
          "start": 3742
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354906.1:c.2623A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341835.1:p.Arg875Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522744"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3531,
          "referenceAllele": "A",
          "start": 3530
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_000038.6:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000029.2:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662295",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000257430.9:c.3472A>T"
          },
          "RefSeq": {
            "hgvs": "NM_000038.6:c.3472A>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000257430.4:p.Arg1158Ter"
          },
          "RefSeq": {
            "hgvs": "NP_000029.2:p.Arg1158Ter"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3639,
          "referenceAllele": "A",
          "start": 3638
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127510.3:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120982.1:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676902"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3638,
          "referenceAllele": "A",
          "start": 3637
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001127511.3:c.3418A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001120983.2:p.Arg1140Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676903"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3875,
          "referenceAllele": "A",
          "start": 3874
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354895.2:c.3472A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341824.1:p.Arg1158Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690347"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3585,
          "referenceAllele": "A",
          "start": 3584
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354896.2:c.3526A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341825.1:p.Arg1176Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690348"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3722,
          "referenceAllele": "A",
          "start": 3721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354897.2:c.3502A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341826.1:p.Arg1168Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690349"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3486,
          "referenceAllele": "A",
          "start": 3485
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354898.2:c.3397A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341827.1:p.Arg1133Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690350"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3447,
          "referenceAllele": "A",
          "start": 3446
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354899.2:c.3388A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341828.1:p.Arg1130Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690351"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3432,
          "referenceAllele": "A",
          "start": 3431
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354900.2:c.3349A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341829.1:p.Arg1117Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690352"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3378,
          "referenceAllele": "A",
          "start": 3377
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354901.2:c.3295A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341830.1:p.Arg1099Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690353"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3419,
          "referenceAllele": "A",
          "start": 3418
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354902.2:c.3199A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341831.1:p.Arg1067Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690354"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3228,
          "referenceAllele": "A",
          "start": 3227
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354903.2:c.3169A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341832.1:p.Arg1057Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690355"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3183,
          "referenceAllele": "A",
          "start": 3182
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354904.2:c.3094A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341833.1:p.Arg1032Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690356"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3075,
          "referenceAllele": "A",
          "start": 3074
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354905.2:c.2992A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341834.1:p.Arg998Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690357"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3717,
          "referenceAllele": "A",
          "start": 3716
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000583",
      "geneNCBI_id": 324,
      "geneSymbol": "APC",
      "hgvs": [
        "NM_001354906.2:c.2623A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341835.1:p.Arg875Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690358"
    }
  ],
  "type": "nucleotide"
}