{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA007813",
  "communityStandardTitle": [
    "NM_000249.4(MLH1):c.1964T>C (p.Ile655Thr)"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=50077[alleleid]",
        "alleleId": 50077,
        "preferredName": "NM_000249.4(MLH1):c.1964T>C (p.Ile655Thr)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/41638",
        "RCV": [
          "RCV000034544",
          "RCV000128924",
          "RCV000148623",
          "RCV000662533",
          "RCV000781539",
          "RCV001085205",
          "RCV003944879"
        ],
        "variationId": 41638
      }
    ],
    "ExAC": [
      {
        "@id": "http://exac.broadinstitute.org/variant/3-37090075-T-C",
        "id": "3-37090075-T-C",
        "variant": "3:37090075 T / C"
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr3:g.37090075T>C?assembly=hg19",
        "id": "chr3:g.37090075T>C"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr3:g.37048584T>C?assembly=hg38",
        "id": "chr3:g.37048584T>C"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/63751225",
        "rs": 63751225
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/3-37090075-T-C?dataset=gnomad_r2_1",
        "id": "3-37090075-T-C",
        "variant": "3:37090075 T / C"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/3-37048584-T-C?dataset=gnomad_r3",
        "id": "3-37048584-T-C",
        "variant": "3:37048584 T / C"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/3-37048584-T-C?dataset=gnomad_r4",
        "id": "3-37048584-T-C",
        "variant": "3:37048584 T / C"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "C",
          "end": 37048584,
          "referenceAllele": "T",
          "start": 37048583
        }
      ],
      "hgvs": [
        "NC_000003.12:g.37048584T>C",
        "CM000665.2:g.37048584T>C"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000051"
    },
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "C",
          "end": 37090075,
          "referenceAllele": "T",
          "start": 37090074
        }
      ],
      "hgvs": [
        "NC_000003.11:g.37090075T>C",
        "CM000665.1:g.37090075T>C"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000027"
    },
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "C",
          "end": 37065079,
          "referenceAllele": "T",
          "start": 37065078
        }
      ],
      "hgvs": [
        "NC_000003.10:g.37065079T>C"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000003"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 60235,
          "referenceAllele": "T",
          "start": 60234
        }
      ],
      "hgvs": [
        "NG_007109.2:g.60235T>C",
        "LRG_216:g.60235T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000485"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1858,
          "endIntronDirection": "-",
          "endIntronOffset": 1901,
          "referenceAllele": "T",
          "start": 1858,
          "startIntronDirection": "-",
          "startIntronOffset": 1902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000413740.2:c.1668-1902T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416476.2:n.1668-1902T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914028"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1982,
          "referenceAllele": "T",
          "start": 1981
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000429117.6:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000407019.2:p.Ile557Thr",
        "hgvsWellDefined": "ENSP00000407019.2:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914050"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1588,
          "endIntronDirection": "-",
          "endIntronOffset": 1901,
          "referenceAllele": "T",
          "start": 1588,
          "startIntronDirection": "-",
          "startIntronOffset": 1902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000450420.6:c.1559-1902T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000393006.2:n.1559-1902T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914085"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1926,
          "endIntronDirection": "+",
          "endIntronOffset": 901,
          "referenceAllele": "T",
          "start": 1926,
          "startIntronDirection": "+",
          "startIntronOffset": 900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000456676.7:c.1896+901T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416687.3:n.1896+901T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914097"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2022,
          "referenceAllele": "T",
          "start": 2021
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000492474.6:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000518393.1:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000518393.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914167"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1972,
          "endIntronDirection": "-",
          "endIntronOffset": 319,
          "referenceAllele": "T",
          "start": 1972,
          "startIntronDirection": "-",
          "startIntronOffset": 320
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000616768.6:c.1897-320T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480669.3:n.1897-320T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914365"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2121,
          "referenceAllele": "T",
          "start": 2120
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673673.2:c.1799T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000500979.2:p.Ile600Thr",
        "hgvsWellDefined": "ENSP00000500979.2:p.Ile600Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914447"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1994,
          "referenceAllele": "T",
          "start": 1993
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000231790.8:c.1964T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000231790.3:p.Ile655Thr",
        "hgvsWellDefined": "ENSP00000231790.3:p.Ile655Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740875",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000231790.8:c.1964T>C"
          },
          "RefSeq": {
            "hgvs": "NM_000249.4:c.1964T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000231790.3:p.Ile655Thr"
          },
          "RefSeq": {
            "hgvs": "NP_000240.1:p.Ile655Thr"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1706,
          "referenceAllele": "T",
          "start": 1705
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000413212.2:c.*882T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000400844.2:n.*882T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754523"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1967,
          "referenceAllele": "T",
          "start": 1966
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000432299.6:c.*1796T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416783.1:n.*1796T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS755407"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1786,
          "referenceAllele": "T",
          "start": 1785
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000447829.6:c.*1075T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000399329.2:n.*1075T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756143"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1843,
          "referenceAllele": "T",
          "start": 1842
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000539477.6:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000443665.1:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000443665.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS759598"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 933,
          "endIntronDirection": "-",
          "endIntronOffset": 319,
          "referenceAllele": "T",
          "start": 933,
          "startIntronDirection": "-",
          "startIntronOffset": 320
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000616768.5:c.934-320T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480669.2:n.934-320T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS762077"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1752,
          "referenceAllele": "T",
          "start": 1751
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673673.1:c.1752T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS773774"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 998,
          "referenceAllele": "T",
          "start": 997
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673741.1:n.998T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS773833"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1346,
          "referenceAllele": "T",
          "start": 1345
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673889.1:n.1346T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS773946"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1890,
          "referenceAllele": "T",
          "start": 1889
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673897.1:c.*1756T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501109.1:n.*1756T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773953"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1291,
          "referenceAllele": "T",
          "start": 1290
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673899.1:c.1232T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501030.1:p.Ile411Thr",
        "hgvsWellDefined": "ENSP00000501030.1:p.Ile411Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773955"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2230,
          "referenceAllele": "T",
          "start": 2229
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673947.1:c.*2104T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501304.1:n.*2104T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773999"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1992,
          "referenceAllele": "T",
          "start": 1991
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673972.1:c.*1842T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501281.1:n.*1842T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS774014"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2099,
          "referenceAllele": "T",
          "start": 2098
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000674019.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501081.1:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000501081.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS774050"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1953,
          "referenceAllele": "T",
          "start": 1952
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000674111.1:c.*193T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501162.1:n.*193T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS774130"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 675,
          "referenceAllele": "T",
          "start": 674
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000674125.1:n.675T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS774144"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2180,
          "referenceAllele": "T",
          "start": 2179
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000231790.6:c.1964T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000231790.2:p.Ile655Thr",
        "hgvsWellDefined": "ENSP00000231790.2:p.Ile655Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246728"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 290,
          "endIntronDirection": "-",
          "endIntronOffset": 1901,
          "referenceAllele": "T",
          "start": 290,
          "startIntronDirection": "-",
          "startIntronOffset": 1902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000413740.1:c.291-1902T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416476.1:n.291-1902T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247196"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1930,
          "referenceAllele": "T",
          "start": 1929
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000435176.5:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000402564.1:p.Ile557Thr",
        "hgvsWellDefined": "ENSP00000402564.1:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247390"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 181,
          "endIntronDirection": "-",
          "endIntronOffset": 1901,
          "referenceAllele": "T",
          "start": 181,
          "startIntronDirection": "-",
          "startIntronOffset": 1902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000450420.5:c.182-1902T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000393006.1:n.182-1902T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247407"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1936,
          "referenceAllele": "T",
          "start": 1935
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000455445.6:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398272.2:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000398272.2:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247178"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1871,
          "endIntronDirection": "+",
          "endIntronOffset": 901,
          "referenceAllele": "T",
          "start": 1871,
          "startIntronDirection": "+",
          "startIntronOffset": 900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000456676.6:c.1871+901T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS247416"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2108,
          "referenceAllele": "T",
          "start": 2107
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000458205.6:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000402667.2:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000402667.2:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247365"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2071,
          "referenceAllele": "T",
          "start": 2070
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000536378.5:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000444286.2:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000444286.2:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247118"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1870,
          "referenceAllele": "T",
          "start": 1869
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000539477.5:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000443665.1:p.Ile414Thr",
        "hgvsWellDefined": "ENSP00000443665.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247348"
    },
    {
      "@id": "http://reg.genome.network/allele/PA211653",
      "coordinates": [
        {
          "allele": "C",
          "end": 2162,
          "referenceAllele": "T",
          "start": 2161
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_000249.3:c.1964T>C",
        "LRG_216t1:c.1964T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000240.1:p.Ile655Thr",
        "hgvsWellDefined": "NP_000240.1:p.Ile655Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006311"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826039328",
      "coordinates": [
        {
          "allele": "C",
          "end": 1957,
          "referenceAllele": "T",
          "start": 1956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167617.1:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161089.1:p.Ile557Thr",
        "hgvsWellDefined": "NP_001161089.1:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS014972"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826041169",
      "coordinates": [
        {
          "allele": "C",
          "end": 1957,
          "referenceAllele": "T",
          "start": 1956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167618.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161090.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001161090.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS014973"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826043013",
      "coordinates": [
        {
          "allele": "C",
          "end": 1870,
          "referenceAllele": "T",
          "start": 1869
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167619.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161091.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001161091.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS014974"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2094,
          "endIntronDirection": "+",
          "endIntronOffset": 901,
          "referenceAllele": "T",
          "start": 2094,
          "startIntronDirection": "+",
          "startIntronOffset": 900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258271.1:c.1896+901T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245200.1:n.1896+901T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS019757"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826460385",
      "coordinates": [
        {
          "allele": "C",
          "end": 2071,
          "referenceAllele": "T",
          "start": 2070
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258273.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245202.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001245202.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS019759"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826462228",
      "coordinates": [
        {
          "allele": "C",
          "end": 2107,
          "referenceAllele": "T",
          "start": 2106
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258274.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245203.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001245203.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS019760"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1845,
          "referenceAllele": "T",
          "start": 1844
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265161.1:c.1757T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265218.1:p.Ile586Thr",
        "hgvsWellDefined": "XP_005265218.1:p.Ile586Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064527"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1962,
          "referenceAllele": "T",
          "start": 1961
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265163.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265220.1:p.Ile414Thr",
        "hgvsWellDefined": "XP_005265220.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064528"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2015,
          "referenceAllele": "T",
          "start": 2014
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265164.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265221.1:p.Ile414Thr",
        "hgvsWellDefined": "XP_005265221.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064529"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1876,
          "referenceAllele": "T",
          "start": 1875
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265166.1:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265223.1:p.Ile314Thr",
        "hgvsWellDefined": "XP_005265223.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064530"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1722,
          "referenceAllele": "T",
          "start": 1721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_011533727.1:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011532029.1:p.Ile297Thr",
        "hgvsWellDefined": "XP_011532029.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS100748"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826039328",
      "coordinates": [
        {
          "allele": "C",
          "end": 2384,
          "referenceAllele": "T",
          "start": 2383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167617.2:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161089.1:p.Ile557Thr",
        "hgvsWellDefined": "NP_001161089.1:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511683"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826041169",
      "coordinates": [
        {
          "allele": "C",
          "end": 2384,
          "referenceAllele": "T",
          "start": 2383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167618.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161090.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001161090.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511684"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826043013",
      "coordinates": [
        {
          "allele": "C",
          "end": 2297,
          "referenceAllele": "T",
          "start": 2296
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167619.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161091.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001161091.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511685"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826462228",
      "coordinates": [
        {
          "allele": "C",
          "end": 2534,
          "referenceAllele": "T",
          "start": 2533
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258274.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245203.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001245203.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511992"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827886393",
      "coordinates": [
        {
          "allele": "C",
          "end": 2065,
          "referenceAllele": "T",
          "start": 2064
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354615.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341544.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341544.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522556"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827888236",
      "coordinates": [
        {
          "allele": "C",
          "end": 2065,
          "referenceAllele": "T",
          "start": 2064
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354616.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341545.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341545.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522557"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827890080",
      "coordinates": [
        {
          "allele": "C",
          "end": 2157,
          "referenceAllele": "T",
          "start": 2156
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354617.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341546.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341546.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522558"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827891922",
      "coordinates": [
        {
          "allele": "C",
          "end": 2389,
          "referenceAllele": "T",
          "start": 2388
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354618.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341547.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341547.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522559"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827893530",
      "coordinates": [
        {
          "allele": "C",
          "end": 2513,
          "referenceAllele": "T",
          "start": 2512
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354619.1:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341548.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341548.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522560"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827895695",
      "coordinates": [
        {
          "allele": "C",
          "end": 2152,
          "referenceAllele": "T",
          "start": 2151
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354620.1:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341549.1:p.Ile557Thr",
        "hgvsWellDefined": "NP_001341549.1:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522561"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827897163",
      "coordinates": [
        {
          "allele": "C",
          "end": 2182,
          "referenceAllele": "T",
          "start": 2181
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354621.1:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341550.1:p.Ile314Thr",
        "hgvsWellDefined": "NP_001341550.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522562"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827898633",
      "coordinates": [
        {
          "allele": "C",
          "end": 2295,
          "referenceAllele": "T",
          "start": 2294
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354622.1:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341551.1:p.Ile314Thr",
        "hgvsWellDefined": "NP_001341551.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522563"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827899917",
      "coordinates": [
        {
          "allele": "C",
          "end": 2204,
          "referenceAllele": "T",
          "start": 2203
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354623.1:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341552.1:p.Ile314Thr",
        "hgvsWellDefined": "NP_001341552.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522564"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827901327",
      "coordinates": [
        {
          "allele": "C",
          "end": 1914,
          "referenceAllele": "T",
          "start": 1913
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354624.1:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341553.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341553.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522565"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827902741",
      "coordinates": [
        {
          "allele": "C",
          "end": 1812,
          "referenceAllele": "T",
          "start": 1811
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354625.1:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341554.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341554.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522566"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827904148",
      "coordinates": [
        {
          "allele": "C",
          "end": 1909,
          "referenceAllele": "T",
          "start": 1908
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354626.1:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341555.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341555.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522567"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827905317",
      "coordinates": [
        {
          "allele": "C",
          "end": 2141,
          "referenceAllele": "T",
          "start": 2140
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354627.1:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341556.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341556.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522568"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2094,
          "endIntronDirection": "-",
          "endIntronOffset": 319,
          "referenceAllele": "T",
          "start": 2094,
          "startIntronDirection": "-",
          "startIntronOffset": 320
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354628.1:c.1897-320T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341557.1:n.1897-320T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522569"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827910621",
      "coordinates": [
        {
          "allele": "C",
          "end": 2063,
          "referenceAllele": "T",
          "start": 2062
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354629.1:c.1865T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341558.1:p.Ile622Thr",
        "hgvsWellDefined": "NP_001341558.1:p.Ile622Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522570"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827912301",
      "coordinates": [
        {
          "allele": "C",
          "end": 1997,
          "referenceAllele": "T",
          "start": 1996
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354630.1:c.1799T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341559.1:p.Ile600Thr",
        "hgvsWellDefined": "NP_001341559.1:p.Ile600Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522571"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1818,
          "referenceAllele": "T",
          "start": 1817
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265161.2:c.1757T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265218.1:p.Ile586Thr",
        "hgvsWellDefined": "XP_005265218.1:p.Ile586Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS536007"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1794,
          "referenceAllele": "T",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_017006450.2:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016861939.1:p.Ile314Thr",
        "hgvsWellDefined": "XP_016861939.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS561484"
    },
    {
      "@id": "http://reg.genome.network/allele/PA211653",
      "coordinates": [
        {
          "allele": "C",
          "end": 1994,
          "referenceAllele": "T",
          "start": 1993
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_000249.4:c.1964T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000240.1:p.Ile655Thr",
        "hgvsWellDefined": "NP_000240.1:p.Ile655Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674761",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000231790.8:c.1964T>C"
          },
          "RefSeq": {
            "hgvs": "NM_000249.4:c.1964T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000231790.3:p.Ile655Thr"
          },
          "RefSeq": {
            "hgvs": "NP_000240.1:p.Ile655Thr"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826039328",
      "coordinates": [
        {
          "allele": "C",
          "end": 2216,
          "referenceAllele": "T",
          "start": 2215
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167617.3:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161089.1:p.Ile557Thr",
        "hgvsWellDefined": "NP_001161089.1:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS713242"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826041169",
      "coordinates": [
        {
          "allele": "C",
          "end": 2216,
          "referenceAllele": "T",
          "start": 2215
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167618.3:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161090.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001161090.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS713243"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826043013",
      "coordinates": [
        {
          "allele": "C",
          "end": 2129,
          "referenceAllele": "T",
          "start": 2128
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167619.3:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161091.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001161091.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS713244"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1926,
          "endIntronDirection": "+",
          "endIntronOffset": 901,
          "referenceAllele": "T",
          "start": 1926,
          "startIntronDirection": "+",
          "startIntronOffset": 900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258271.2:c.1896+901T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245200.1:n.1896+901T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714924"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826460385",
      "coordinates": [
        {
          "allele": "C",
          "end": 1903,
          "referenceAllele": "T",
          "start": 1902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258273.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245202.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001245202.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714925"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826462228",
      "coordinates": [
        {
          "allele": "C",
          "end": 2366,
          "referenceAllele": "T",
          "start": 2365
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258274.3:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245203.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001245203.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714926"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827886393",
      "coordinates": [
        {
          "allele": "C",
          "end": 1897,
          "referenceAllele": "T",
          "start": 1896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354615.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341544.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341544.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720517"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827888236",
      "coordinates": [
        {
          "allele": "C",
          "end": 1897,
          "referenceAllele": "T",
          "start": 1896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354616.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341545.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341545.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720518"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827890080",
      "coordinates": [
        {
          "allele": "C",
          "end": 1989,
          "referenceAllele": "T",
          "start": 1988
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354617.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341546.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341546.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720519"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827891922",
      "coordinates": [
        {
          "allele": "C",
          "end": 2221,
          "referenceAllele": "T",
          "start": 2220
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354618.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341547.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341547.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720520"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827893530",
      "coordinates": [
        {
          "allele": "C",
          "end": 2345,
          "referenceAllele": "T",
          "start": 2344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354619.2:c.1241T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341548.1:p.Ile414Thr",
        "hgvsWellDefined": "NP_001341548.1:p.Ile414Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720521"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827895695",
      "coordinates": [
        {
          "allele": "C",
          "end": 1984,
          "referenceAllele": "T",
          "start": 1983
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354620.2:c.1670T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341549.1:p.Ile557Thr",
        "hgvsWellDefined": "NP_001341549.1:p.Ile557Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720522"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827897163",
      "coordinates": [
        {
          "allele": "C",
          "end": 2014,
          "referenceAllele": "T",
          "start": 2013
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354621.2:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341550.1:p.Ile314Thr",
        "hgvsWellDefined": "NP_001341550.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720523"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827898633",
      "coordinates": [
        {
          "allele": "C",
          "end": 2127,
          "referenceAllele": "T",
          "start": 2126
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354622.2:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341551.1:p.Ile314Thr",
        "hgvsWellDefined": "NP_001341551.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720524"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827899917",
      "coordinates": [
        {
          "allele": "C",
          "end": 2036,
          "referenceAllele": "T",
          "start": 2035
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354623.2:c.941T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341552.1:p.Ile314Thr",
        "hgvsWellDefined": "NP_001341552.1:p.Ile314Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720525"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827901327",
      "coordinates": [
        {
          "allele": "C",
          "end": 1746,
          "referenceAllele": "T",
          "start": 1745
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354624.2:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341553.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341553.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720526"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827902741",
      "coordinates": [
        {
          "allele": "C",
          "end": 1644,
          "referenceAllele": "T",
          "start": 1643
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354625.2:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341554.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341554.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720527"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827904148",
      "coordinates": [
        {
          "allele": "C",
          "end": 1741,
          "referenceAllele": "T",
          "start": 1740
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354626.2:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341555.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341555.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720528"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827905317",
      "coordinates": [
        {
          "allele": "C",
          "end": 1973,
          "referenceAllele": "T",
          "start": 1972
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354627.2:c.890T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341556.1:p.Ile297Thr",
        "hgvsWellDefined": "NP_001341556.1:p.Ile297Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720529"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1926,
          "endIntronDirection": "-",
          "endIntronOffset": 319,
          "referenceAllele": "T",
          "start": 1926,
          "startIntronDirection": "-",
          "startIntronOffset": 320
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354628.2:c.1897-320T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341557.1:n.1897-320T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720530"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827910621",
      "coordinates": [
        {
          "allele": "C",
          "end": 1895,
          "referenceAllele": "T",
          "start": 1894
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354629.2:c.1865T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341558.1:p.Ile622Thr",
        "hgvsWellDefined": "NP_001341558.1:p.Ile622Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720531"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827912301",
      "coordinates": [
        {
          "allele": "C",
          "end": 1829,
          "referenceAllele": "T",
          "start": 1828
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354630.2:c.1799T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341559.1:p.Ile600Thr",
        "hgvsWellDefined": "NP_001341559.1:p.Ile600Thr"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720532"
    }
  ],
  "type": "nucleotide"
}