{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA007760",
  "communityStandardTitle": [
    "NM_000249.4(MLH1):c.1958T>G (p.Leu653Arg)"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=95431[alleleid]",
        "alleleId": 95431,
        "preferredName": "NM_000249.4(MLH1):c.1958T>G (p.Leu653Arg)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/89957",
        "RCV": [
          "RCV000075437",
          "RCV001203288",
          "RCV002415523",
          "RCV003451086"
        ],
        "variationId": 89957
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr3:g.37090069T>G?assembly=hg19",
        "id": "chr3:g.37090069T>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr3:g.37048578T>G?assembly=hg38",
        "id": "chr3:g.37048578T>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/63751202",
        "rs": 63751202
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "G",
          "end": 37048578,
          "referenceAllele": "T",
          "start": 37048577
        }
      ],
      "hgvs": [
        "NC_000003.12:g.37048578T>G",
        "CM000665.2:g.37048578T>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000051"
    },
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "G",
          "end": 37090069,
          "referenceAllele": "T",
          "start": 37090068
        }
      ],
      "hgvs": [
        "NC_000003.11:g.37090069T>G",
        "CM000665.1:g.37090069T>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000027"
    },
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "G",
          "end": 37065073,
          "referenceAllele": "T",
          "start": 37065072
        }
      ],
      "hgvs": [
        "NC_000003.10:g.37065073T>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000003"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 60229,
          "referenceAllele": "T",
          "start": 60228
        }
      ],
      "hgvs": [
        "NG_007109.2:g.60229T>G",
        "LRG_216:g.60229T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000485"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1858,
          "endIntronDirection": "-",
          "endIntronOffset": 1907,
          "referenceAllele": "T",
          "start": 1858,
          "startIntronDirection": "-",
          "startIntronOffset": 1908
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000413740.2:c.1668-1908T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416476.2:n.1668-1908T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914028"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1976,
          "referenceAllele": "T",
          "start": 1975
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000429117.6:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000407019.2:p.Leu555Arg",
        "hgvsWellDefined": "ENSP00000407019.2:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914050"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1588,
          "endIntronDirection": "-",
          "endIntronOffset": 1907,
          "referenceAllele": "T",
          "start": 1588,
          "startIntronDirection": "-",
          "startIntronOffset": 1908
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000450420.6:c.1559-1908T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000393006.2:n.1559-1908T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914085"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1926,
          "endIntronDirection": "+",
          "endIntronOffset": 895,
          "referenceAllele": "T",
          "start": 1926,
          "startIntronDirection": "+",
          "startIntronOffset": 894
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000456676.7:c.1896+895T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416687.3:n.1896+895T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914097"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2016,
          "referenceAllele": "T",
          "start": 2015
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000492474.6:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000518393.1:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000518393.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914167"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1972,
          "endIntronDirection": "-",
          "endIntronOffset": 325,
          "referenceAllele": "T",
          "start": 1972,
          "startIntronDirection": "-",
          "startIntronOffset": 326
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000616768.6:c.1897-326T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480669.3:n.1897-326T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914365"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2115,
          "referenceAllele": "T",
          "start": 2114
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673673.2:c.1793T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000500979.2:p.Leu598Arg",
        "hgvsWellDefined": "ENSP00000500979.2:p.Leu598Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914447"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1988,
          "referenceAllele": "T",
          "start": 1987
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000231790.8:c.1958T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000231790.3:p.Leu653Arg",
        "hgvsWellDefined": "ENSP00000231790.3:p.Leu653Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740875",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000231790.8:c.1958T>G"
          },
          "RefSeq": {
            "hgvs": "NM_000249.4:c.1958T>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000231790.3:p.Leu653Arg"
          },
          "RefSeq": {
            "hgvs": "NP_000240.1:p.Leu653Arg"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1700,
          "referenceAllele": "T",
          "start": 1699
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000413212.2:c.*876T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000400844.2:n.*876T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754523"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1961,
          "referenceAllele": "T",
          "start": 1960
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000432299.6:c.*1790T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416783.1:n.*1790T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS755407"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1780,
          "referenceAllele": "T",
          "start": 1779
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000447829.6:c.*1069T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000399329.2:n.*1069T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756143"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1837,
          "referenceAllele": "T",
          "start": 1836
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000539477.6:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000443665.1:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000443665.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS759598"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 933,
          "endIntronDirection": "-",
          "endIntronOffset": 325,
          "referenceAllele": "T",
          "start": 933,
          "startIntronDirection": "-",
          "startIntronOffset": 326
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000616768.5:c.934-326T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480669.2:n.934-326T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS762077"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1746,
          "referenceAllele": "T",
          "start": 1745
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673673.1:c.1746T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS773774"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 992,
          "referenceAllele": "T",
          "start": 991
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673741.1:n.992T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS773833"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1340,
          "referenceAllele": "T",
          "start": 1339
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673889.1:n.1340T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS773946"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1884,
          "referenceAllele": "T",
          "start": 1883
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673897.1:c.*1750T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501109.1:n.*1750T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773953"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1285,
          "referenceAllele": "T",
          "start": 1284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673899.1:c.1226T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501030.1:p.Leu409Arg",
        "hgvsWellDefined": "ENSP00000501030.1:p.Leu409Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773955"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2224,
          "referenceAllele": "T",
          "start": 2223
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673947.1:c.*2098T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501304.1:n.*2098T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS773999"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1986,
          "referenceAllele": "T",
          "start": 1985
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000673972.1:c.*1836T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501281.1:n.*1836T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS774014"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2093,
          "referenceAllele": "T",
          "start": 2092
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000674019.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501081.1:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000501081.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS774050"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1947,
          "referenceAllele": "T",
          "start": 1946
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000674111.1:c.*187T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501162.1:n.*187T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS774130"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 669,
          "referenceAllele": "T",
          "start": 668
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000674125.1:n.669T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS774144"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2174,
          "referenceAllele": "T",
          "start": 2173
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000231790.6:c.1958T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000231790.2:p.Leu653Arg",
        "hgvsWellDefined": "ENSP00000231790.2:p.Leu653Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246728"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 290,
          "endIntronDirection": "-",
          "endIntronOffset": 1907,
          "referenceAllele": "T",
          "start": 290,
          "startIntronDirection": "-",
          "startIntronOffset": 1908
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000413740.1:c.291-1908T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000416476.1:n.291-1908T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247196"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1924,
          "referenceAllele": "T",
          "start": 1923
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000435176.5:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000402564.1:p.Leu555Arg",
        "hgvsWellDefined": "ENSP00000402564.1:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247390"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 181,
          "endIntronDirection": "-",
          "endIntronOffset": 1907,
          "referenceAllele": "T",
          "start": 181,
          "startIntronDirection": "-",
          "startIntronOffset": 1908
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000450420.5:c.182-1908T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000393006.1:n.182-1908T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247407"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1930,
          "referenceAllele": "T",
          "start": 1929
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000455445.6:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398272.2:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000398272.2:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247178"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1871,
          "endIntronDirection": "+",
          "endIntronOffset": 895,
          "referenceAllele": "T",
          "start": 1871,
          "startIntronDirection": "+",
          "startIntronOffset": 894
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000456676.6:c.1871+895T>G"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS247416"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2102,
          "referenceAllele": "T",
          "start": 2101
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000458205.6:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000402667.2:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000402667.2:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247365"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2065,
          "referenceAllele": "T",
          "start": 2064
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000536378.5:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000444286.2:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000444286.2:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247118"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1864,
          "referenceAllele": "T",
          "start": 1863
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "ENST00000539477.5:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000443665.1:p.Leu412Arg",
        "hgvsWellDefined": "ENSP00000443665.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247348"
    },
    {
      "@id": "http://reg.genome.network/allele/PA330858",
      "coordinates": [
        {
          "allele": "G",
          "end": 2156,
          "referenceAllele": "T",
          "start": 2155
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_000249.3:c.1958T>G",
        "LRG_216t1:c.1958T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000240.1:p.Leu653Arg",
        "hgvsWellDefined": "NP_000240.1:p.Leu653Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006311"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826039321",
      "coordinates": [
        {
          "allele": "G",
          "end": 1951,
          "referenceAllele": "T",
          "start": 1950
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167617.1:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161089.1:p.Leu555Arg",
        "hgvsWellDefined": "NP_001161089.1:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS014972"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826041163",
      "coordinates": [
        {
          "allele": "G",
          "end": 1951,
          "referenceAllele": "T",
          "start": 1950
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167618.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161090.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001161090.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS014973"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826043005",
      "coordinates": [
        {
          "allele": "G",
          "end": 1864,
          "referenceAllele": "T",
          "start": 1863
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167619.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161091.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001161091.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS014974"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2094,
          "endIntronDirection": "+",
          "endIntronOffset": 895,
          "referenceAllele": "T",
          "start": 2094,
          "startIntronDirection": "+",
          "startIntronOffset": 894
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258271.1:c.1896+895T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245200.1:n.1896+895T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS019757"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826460378",
      "coordinates": [
        {
          "allele": "G",
          "end": 2065,
          "referenceAllele": "T",
          "start": 2064
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258273.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245202.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001245202.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS019759"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826462221",
      "coordinates": [
        {
          "allele": "G",
          "end": 2101,
          "referenceAllele": "T",
          "start": 2100
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258274.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245203.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001245203.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS019760"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1839,
          "referenceAllele": "T",
          "start": 1838
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265161.1:c.1751T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265218.1:p.Leu584Arg",
        "hgvsWellDefined": "XP_005265218.1:p.Leu584Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064527"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1956,
          "referenceAllele": "T",
          "start": 1955
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265163.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265220.1:p.Leu412Arg",
        "hgvsWellDefined": "XP_005265220.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064528"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2009,
          "referenceAllele": "T",
          "start": 2008
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265164.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265221.1:p.Leu412Arg",
        "hgvsWellDefined": "XP_005265221.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064529"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1870,
          "referenceAllele": "T",
          "start": 1869
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265166.1:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265223.1:p.Leu312Arg",
        "hgvsWellDefined": "XP_005265223.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS064530"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1716,
          "referenceAllele": "T",
          "start": 1715
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_011533727.1:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_011532029.1:p.Leu295Arg",
        "hgvsWellDefined": "XP_011532029.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS100748"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826039321",
      "coordinates": [
        {
          "allele": "G",
          "end": 2378,
          "referenceAllele": "T",
          "start": 2377
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167617.2:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161089.1:p.Leu555Arg",
        "hgvsWellDefined": "NP_001161089.1:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511683"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826041163",
      "coordinates": [
        {
          "allele": "G",
          "end": 2378,
          "referenceAllele": "T",
          "start": 2377
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167618.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161090.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001161090.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511684"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826043005",
      "coordinates": [
        {
          "allele": "G",
          "end": 2291,
          "referenceAllele": "T",
          "start": 2290
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167619.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161091.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001161091.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511685"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826462221",
      "coordinates": [
        {
          "allele": "G",
          "end": 2528,
          "referenceAllele": "T",
          "start": 2527
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258274.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245203.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001245203.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS511992"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827886386",
      "coordinates": [
        {
          "allele": "G",
          "end": 2059,
          "referenceAllele": "T",
          "start": 2058
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354615.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341544.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341544.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522556"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827888230",
      "coordinates": [
        {
          "allele": "G",
          "end": 2059,
          "referenceAllele": "T",
          "start": 2058
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354616.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341545.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341545.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522557"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827890073",
      "coordinates": [
        {
          "allele": "G",
          "end": 2151,
          "referenceAllele": "T",
          "start": 2150
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354617.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341546.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341546.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522558"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827891916",
      "coordinates": [
        {
          "allele": "G",
          "end": 2383,
          "referenceAllele": "T",
          "start": 2382
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354618.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341547.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341547.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522559"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827893522",
      "coordinates": [
        {
          "allele": "G",
          "end": 2507,
          "referenceAllele": "T",
          "start": 2506
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354619.1:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341548.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341548.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522560"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827895688",
      "coordinates": [
        {
          "allele": "G",
          "end": 2146,
          "referenceAllele": "T",
          "start": 2145
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354620.1:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341549.1:p.Leu555Arg",
        "hgvsWellDefined": "NP_001341549.1:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522561"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827897156",
      "coordinates": [
        {
          "allele": "G",
          "end": 2176,
          "referenceAllele": "T",
          "start": 2175
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354621.1:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341550.1:p.Leu312Arg",
        "hgvsWellDefined": "NP_001341550.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522562"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827898626",
      "coordinates": [
        {
          "allele": "G",
          "end": 2289,
          "referenceAllele": "T",
          "start": 2288
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354622.1:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341551.1:p.Leu312Arg",
        "hgvsWellDefined": "NP_001341551.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522563"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827899908",
      "coordinates": [
        {
          "allele": "G",
          "end": 2198,
          "referenceAllele": "T",
          "start": 2197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354623.1:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341552.1:p.Leu312Arg",
        "hgvsWellDefined": "NP_001341552.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522564"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827901321",
      "coordinates": [
        {
          "allele": "G",
          "end": 1908,
          "referenceAllele": "T",
          "start": 1907
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354624.1:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341553.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341553.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522565"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827902731",
      "coordinates": [
        {
          "allele": "G",
          "end": 1806,
          "referenceAllele": "T",
          "start": 1805
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354625.1:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341554.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341554.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522566"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827904142",
      "coordinates": [
        {
          "allele": "G",
          "end": 1903,
          "referenceAllele": "T",
          "start": 1902
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354626.1:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341555.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341555.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522567"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827905310",
      "coordinates": [
        {
          "allele": "G",
          "end": 2135,
          "referenceAllele": "T",
          "start": 2134
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354627.1:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341556.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341556.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522568"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2094,
          "endIntronDirection": "-",
          "endIntronOffset": 325,
          "referenceAllele": "T",
          "start": 2094,
          "startIntronDirection": "-",
          "startIntronOffset": 326
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354628.1:c.1897-326T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341557.1:n.1897-326T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522569"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827910613",
      "coordinates": [
        {
          "allele": "G",
          "end": 2057,
          "referenceAllele": "T",
          "start": 2056
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354629.1:c.1859T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341558.1:p.Leu620Arg",
        "hgvsWellDefined": "NP_001341558.1:p.Leu620Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522570"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827912296",
      "coordinates": [
        {
          "allele": "G",
          "end": 1991,
          "referenceAllele": "T",
          "start": 1990
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354630.1:c.1793T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341559.1:p.Leu598Arg",
        "hgvsWellDefined": "NP_001341559.1:p.Leu598Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522571"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1812,
          "referenceAllele": "T",
          "start": 1811
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_005265161.2:c.1751T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_005265218.1:p.Leu584Arg",
        "hgvsWellDefined": "XP_005265218.1:p.Leu584Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS536007"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1788,
          "referenceAllele": "T",
          "start": 1787
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "XM_017006450.2:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "XP_016861939.1:p.Leu312Arg",
        "hgvsWellDefined": "XP_016861939.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS561484"
    },
    {
      "@id": "http://reg.genome.network/allele/PA330858",
      "coordinates": [
        {
          "allele": "G",
          "end": 1988,
          "referenceAllele": "T",
          "start": 1987
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_000249.4:c.1958T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_000240.1:p.Leu653Arg",
        "hgvsWellDefined": "NP_000240.1:p.Leu653Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674761",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000231790.8:c.1958T>G"
          },
          "RefSeq": {
            "hgvs": "NM_000249.4:c.1958T>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000231790.3:p.Leu653Arg"
          },
          "RefSeq": {
            "hgvs": "NP_000240.1:p.Leu653Arg"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826039321",
      "coordinates": [
        {
          "allele": "G",
          "end": 2210,
          "referenceAllele": "T",
          "start": 2209
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167617.3:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161089.1:p.Leu555Arg",
        "hgvsWellDefined": "NP_001161089.1:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS713242"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826041163",
      "coordinates": [
        {
          "allele": "G",
          "end": 2210,
          "referenceAllele": "T",
          "start": 2209
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167618.3:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161090.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001161090.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS713243"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826043005",
      "coordinates": [
        {
          "allele": "G",
          "end": 2123,
          "referenceAllele": "T",
          "start": 2122
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001167619.3:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001161091.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001161091.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS713244"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1926,
          "endIntronDirection": "+",
          "endIntronOffset": 895,
          "referenceAllele": "T",
          "start": 1926,
          "startIntronDirection": "+",
          "startIntronOffset": 894
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258271.2:c.1896+895T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245200.1:n.1896+895T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714924"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826460378",
      "coordinates": [
        {
          "allele": "G",
          "end": 1897,
          "referenceAllele": "T",
          "start": 1896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258273.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245202.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001245202.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714925"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826462221",
      "coordinates": [
        {
          "allele": "G",
          "end": 2360,
          "referenceAllele": "T",
          "start": 2359
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001258274.3:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001245203.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001245203.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS714926"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827886386",
      "coordinates": [
        {
          "allele": "G",
          "end": 1891,
          "referenceAllele": "T",
          "start": 1890
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354615.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341544.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341544.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720517"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827888230",
      "coordinates": [
        {
          "allele": "G",
          "end": 1891,
          "referenceAllele": "T",
          "start": 1890
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354616.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341545.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341545.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720518"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827890073",
      "coordinates": [
        {
          "allele": "G",
          "end": 1983,
          "referenceAllele": "T",
          "start": 1982
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354617.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341546.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341546.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720519"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827891916",
      "coordinates": [
        {
          "allele": "G",
          "end": 2215,
          "referenceAllele": "T",
          "start": 2214
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354618.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341547.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341547.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720520"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827893522",
      "coordinates": [
        {
          "allele": "G",
          "end": 2339,
          "referenceAllele": "T",
          "start": 2338
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354619.2:c.1235T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341548.1:p.Leu412Arg",
        "hgvsWellDefined": "NP_001341548.1:p.Leu412Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720521"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827895688",
      "coordinates": [
        {
          "allele": "G",
          "end": 1978,
          "referenceAllele": "T",
          "start": 1977
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354620.2:c.1664T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341549.1:p.Leu555Arg",
        "hgvsWellDefined": "NP_001341549.1:p.Leu555Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720522"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827897156",
      "coordinates": [
        {
          "allele": "G",
          "end": 2008,
          "referenceAllele": "T",
          "start": 2007
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354621.2:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341550.1:p.Leu312Arg",
        "hgvsWellDefined": "NP_001341550.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720523"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827898626",
      "coordinates": [
        {
          "allele": "G",
          "end": 2121,
          "referenceAllele": "T",
          "start": 2120
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354622.2:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341551.1:p.Leu312Arg",
        "hgvsWellDefined": "NP_001341551.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720524"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827899908",
      "coordinates": [
        {
          "allele": "G",
          "end": 2030,
          "referenceAllele": "T",
          "start": 2029
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354623.2:c.935T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341552.1:p.Leu312Arg",
        "hgvsWellDefined": "NP_001341552.1:p.Leu312Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720525"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827901321",
      "coordinates": [
        {
          "allele": "G",
          "end": 1740,
          "referenceAllele": "T",
          "start": 1739
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354624.2:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341553.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341553.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720526"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827902731",
      "coordinates": [
        {
          "allele": "G",
          "end": 1638,
          "referenceAllele": "T",
          "start": 1637
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354625.2:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341554.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341554.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720527"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827904142",
      "coordinates": [
        {
          "allele": "G",
          "end": 1735,
          "referenceAllele": "T",
          "start": 1734
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354626.2:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341555.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341555.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720528"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827905310",
      "coordinates": [
        {
          "allele": "G",
          "end": 1967,
          "referenceAllele": "T",
          "start": 1966
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354627.2:c.884T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341556.1:p.Leu295Arg",
        "hgvsWellDefined": "NP_001341556.1:p.Leu295Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720529"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1926,
          "endIntronDirection": "-",
          "endIntronOffset": 325,
          "referenceAllele": "T",
          "start": 1926,
          "startIntronDirection": "-",
          "startIntronOffset": 326
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354628.2:c.1897-326T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341557.1:n.1897-326T>G"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720530"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827910613",
      "coordinates": [
        {
          "allele": "G",
          "end": 1889,
          "referenceAllele": "T",
          "start": 1888
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354629.2:c.1859T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341558.1:p.Leu620Arg",
        "hgvsWellDefined": "NP_001341558.1:p.Leu620Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720531"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827912296",
      "coordinates": [
        {
          "allele": "G",
          "end": 1823,
          "referenceAllele": "T",
          "start": 1822
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007127",
      "geneNCBI_id": 4292,
      "geneSymbol": "MLH1",
      "hgvs": [
        "NM_001354630.2:c.1793T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341559.1:p.Leu598Arg",
        "hgvsWellDefined": "NP_001341559.1:p.Leu598Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS720532"
    }
  ],
  "type": "nucleotide"
}