{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA000398",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.755T>C (p.Leu252Pro)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "active": false,
        "id": "COSM44769"
      },
      {
        "active": false,
        "id": "COSM148174"
      },
      {
        "active": false,
        "id": "COSM148175"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=4735392",
        "active": true,
        "id": "COSM4735392"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=4735393",
        "active": true,
        "id": "COSM4735393"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=27389[alleleid]",
        "alleleId": 27389,
        "preferredName": "NM_000546.6(TP53):c.755T>C (p.Leu252Pro)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/12350",
        "RCV": [
          "RCV000013143",
          "RCV001213570",
          "RCV003237412"
        ],
        "variationId": 12350
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7577526A>G?assembly=hg19",
        "id": "chr17:g.7577526A>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7674208A>G?assembly=hg38",
        "id": "chr17:g.7674208A>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/121912653",
        "rs": 121912653
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "G",
          "end": 7674208,
          "referenceAllele": "A",
          "start": 7674207
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7674208A>G",
        "CM000679.2:g.7674208A>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "G",
          "end": 7577526,
          "referenceAllele": "A",
          "start": 7577525
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7577526A>G",
        "CM000679.1:g.7577526A>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "G",
          "end": 7518251,
          "referenceAllele": "A",
          "start": 7518250
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7518251A>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 18343,
          "referenceAllele": "T",
          "start": 18342
        }
      ],
      "hgvs": [
        "NG_017013.2:g.18343T>C",
        "LRG_321:g.18343T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 937,
          "referenceAllele": "T",
          "start": 936
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000426252.2:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1037,
          "referenceAllele": "T",
          "start": 1036
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000424104.2:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 491,
          "referenceAllele": "T",
          "start": 490
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Leu120Pro",
        "hgvsWellDefined": "ENSP00000425104.2:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 555,
          "referenceAllele": "T",
          "start": 554
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.476T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Leu159Pro",
        "hgvsWellDefined": "ENSP00000423862.2:p.Leu159Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 873,
          "referenceAllele": "T",
          "start": 872
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.734T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Leu245Pro",
        "hgvsWellDefined": "ENSP00000473895.2:p.Leu245Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000269305.4:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.755T>C"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.755T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Leu252Pro"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Leu252Pro"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 945,
          "referenceAllele": "T",
          "start": 944
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000269305.4:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 755,
          "referenceAllele": "T",
          "start": 754
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000352610.4:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 755,
          "referenceAllele": "T",
          "start": 754
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000410739.2:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 888,
          "referenceAllele": "T",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000391127.2:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 891,
          "referenceAllele": "T",
          "start": 890
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000391478.2:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 888,
          "referenceAllele": "T",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000398846.2:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:p.Leu120Pro",
        "hgvsWellDefined": "ENSP00000484409.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Leu120Pro",
        "hgvsWellDefined": "ENSP00000481179.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 491,
          "referenceAllele": "T",
          "start": 490
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.5:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.1:p.Leu120Pro",
        "hgvsWellDefined": "ENSP00000425104.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247215"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:p.Leu120Pro",
        "hgvsWellDefined": "ENSP00000478499.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1005,
          "referenceAllele": "T",
          "start": 1004
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Leu213Pro",
        "hgvsWellDefined": "ENSP00000478219.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 888,
          "referenceAllele": "T",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:p.Leu213Pro",
        "hgvsWellDefined": "ENSP00000480868.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:p.Leu93Pro",
        "hgvsWellDefined": "ENSP00000477531.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 722,
          "referenceAllele": "T",
          "start": 721
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.722T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Leu241Pro",
        "hgvsWellDefined": "ENSP00000482903.1:p.Leu241Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:p.Leu252Pro",
        "hgvsWellDefined": "ENSP00000482258.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:p.Leu93Pro",
        "hgvsWellDefined": "ENSP00000481401.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:p.Leu93Pro",
        "hgvsWellDefined": "ENSP00000484375.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 891,
          "referenceAllele": "T",
          "start": 890
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Leu213Pro",
        "hgvsWellDefined": "ENSP00000482537.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 945,
          "referenceAllele": "T",
          "start": 944
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Leu213Pro",
        "hgvsWellDefined": "ENSP00000481638.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 888,
          "referenceAllele": "T",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:p.Leu213Pro",
        "hgvsWellDefined": "ENSP00000482222.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 898,
          "referenceAllele": "T",
          "start": 897
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Leu213Pro",
        "hgvsWellDefined": "ENSP00000488924.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA107082",
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.755T>C",
        "LRG_321t1:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Leu252Pro",
        "hgvsWellDefined": "NP_000537.3:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256359",
      "coordinates": [
        {
          "allele": "C",
          "end": 954,
          "referenceAllele": "T",
          "start": 953
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.755T>C",
        "LRG_321t2:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Leu252Pro",
        "hgvsWellDefined": "NP_001119584.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256360",
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.755T>C",
        "LRG_321t4:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Leu252Pro",
        "hgvsWellDefined": "NP_001119585.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256361",
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.755T>C",
        "LRG_321t3:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Leu252Pro",
        "hgvsWellDefined": "NP_001119586.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256355",
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.359T>C",
        "LRG_321t5:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Leu120Pro",
        "hgvsWellDefined": "NP_001119587.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256356",
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.359T>C",
        "LRG_321t6:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Leu120Pro",
        "hgvsWellDefined": "NP_001119588.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256357",
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.359T>C",
        "LRG_321t7:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Leu120Pro",
        "hgvsWellDefined": "NP_001119589.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256358",
      "coordinates": [
        {
          "allele": "C",
          "end": 1074,
          "referenceAllele": "T",
          "start": 1073
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.638T>C",
        "LRG_321t8:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001119590.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559984",
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263624.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561442",
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263625.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562351",
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263626.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563474",
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263627.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006429",
      "coordinates": [
        {
          "allele": "C",
          "end": 637,
          "referenceAllele": "T",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263628.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565832",
      "coordinates": [
        {
          "allele": "C",
          "end": 957,
          "referenceAllele": "T",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263689.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567345",
      "coordinates": [
        {
          "allele": "C",
          "end": 954,
          "referenceAllele": "T",
          "start": 953
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263690.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559984",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263624.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561442",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263625.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562351",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263626.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563474",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263627.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006429",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263628.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565832",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263689.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567345",
      "coordinates": [
        {
          "allele": "C",
          "end": 894,
          "referenceAllele": "T",
          "start": 893
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263690.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA107082",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Leu252Pro",
        "hgvsWellDefined": "NP_000537.3:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.755T>C"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.755T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Leu252Pro"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Leu252Pro"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA256359",
      "coordinates": [
        {
          "allele": "C",
          "end": 894,
          "referenceAllele": "T",
          "start": 893
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Leu252Pro",
        "hgvsWellDefined": "NP_001119584.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256360",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Leu252Pro",
        "hgvsWellDefined": "NP_001119585.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256361",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.755T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Leu252Pro",
        "hgvsWellDefined": "NP_001119586.1:p.Leu252Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256355",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Leu120Pro",
        "hgvsWellDefined": "NP_001119587.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256356",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Leu120Pro",
        "hgvsWellDefined": "NP_001119588.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256357",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.359T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Leu120Pro",
        "hgvsWellDefined": "NP_001119589.1:p.Leu120Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "@id": "http://reg.genome.network/allele/PA256358",
      "coordinates": [
        {
          "allele": "C",
          "end": 1014,
          "referenceAllele": "T",
          "start": 1013
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001119590.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559984",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263624.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561442",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263625.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562351",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263626.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563474",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263627.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916006429",
      "coordinates": [
        {
          "allele": "C",
          "end": 388,
          "referenceAllele": "T",
          "start": 387
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.278T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Leu93Pro",
        "hgvsWellDefined": "NP_001263628.1:p.Leu93Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565832",
      "coordinates": [
        {
          "allele": "C",
          "end": 897,
          "referenceAllele": "T",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263689.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567345",
      "coordinates": [
        {
          "allele": "C",
          "end": 894,
          "referenceAllele": "T",
          "start": 893
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.638T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Leu213Pro",
        "hgvsWellDefined": "NP_001263690.1:p.Leu213Pro"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}