{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA000017",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.1015G>A (p.Glu339Lys)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=46153",
        "active": true,
        "id": "COSM46153"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=152560[alleleid]",
        "alleleId": 152560,
        "preferredName": "NM_000546.6(TP53):c.1015G>A (p.Glu339Lys)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/142846",
        "RCV": [
          "RCV000132285",
          "RCV000254694",
          "RCV001030734",
          "RCV001081368",
          "RCV001127282",
          "RCV003891671"
        ],
        "variationId": 142846
      }
    ],
    "ExAC": [
      {
        "@id": "http://exac.broadinstitute.org/variant/17-7574012-C-T",
        "id": "17-7574012-C-T",
        "variant": "17:7574012 C / T"
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7574012C>T?assembly=hg19",
        "id": "chr17:g.7574012C>T"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7670694C>T?assembly=hg38",
        "id": "chr17:g.7670694C>T"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/17882252",
        "rs": 17882252
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/17-7574012-C-T?dataset=gnomad_r2_1",
        "id": "17-7574012-C-T",
        "variant": "17:7574012 C / T"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/17-7670694-C-T?dataset=gnomad_r3",
        "id": "17-7670694-C-T",
        "variant": "17:7670694 C / T"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/17-7670694-C-T?dataset=gnomad_r4",
        "id": "17-7670694-C-T",
        "variant": "17:7670694 C / T"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "T",
          "end": 7670694,
          "referenceAllele": "C",
          "start": 7670693
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7670694C>T",
        "CM000679.2:g.7670694C>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "T",
          "end": 7574012,
          "referenceAllele": "C",
          "start": 7574011
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7574012C>T",
        "CM000679.1:g.7574012C>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "T",
          "end": 7514737,
          "referenceAllele": "C",
          "start": 7514736
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7514737C>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 21857,
          "referenceAllele": "G",
          "start": 21856
        }
      ],
      "hgvs": [
        "NG_017013.2:g.21857G>A",
        "LRG_321:g.21857G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1197,
          "referenceAllele": "G",
          "start": 1196
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Glu339Lys",
        "hgvsWellDefined": "ENSP00000426252.2:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1297,
          "referenceAllele": "G",
          "start": 1296
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Glu339Lys",
        "hgvsWellDefined": "ENSP00000424104.2:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 751,
          "referenceAllele": "G",
          "start": 750
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.619G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Glu207Lys",
        "hgvsWellDefined": "ENSP00000425104.2:p.Glu207Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 815,
          "referenceAllele": "G",
          "start": 814
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.736G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Glu246Lys",
        "hgvsWellDefined": "ENSP00000423862.2:p.Glu246Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1133,
          "referenceAllele": "G",
          "start": 1132
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.994G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Glu332Lys",
        "hgvsWellDefined": "ENSP00000473895.2:p.Glu332Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1157,
          "referenceAllele": "G",
          "start": 1156
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Glu339Lys",
        "hgvsWellDefined": "ENSP00000269305.4:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.1015G>A"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.1015G>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Glu339Lys"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Glu339Lys"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1205,
          "referenceAllele": "G",
          "start": 1204
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Glu339Lys",
        "hgvsWellDefined": "ENSP00000269305.4:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 993,
          "endIntronDirection": "+",
          "endIntronOffset": 2841,
          "referenceAllele": "G",
          "start": 993,
          "startIntronDirection": "+",
          "startIntronOffset": 2840
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.993+2841G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:n.993+2841G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 782,
          "endIntronDirection": "+",
          "endIntronOffset": 3487,
          "referenceAllele": "G",
          "start": 782,
          "startIntronDirection": "+",
          "startIntronOffset": 3486
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.782+3487G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:n.782+3487G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1281,
          "referenceAllele": "G",
          "start": 1280
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1151,
          "referenceAllele": "G",
          "start": 1150
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Glu339Lys",
        "hgvsWellDefined": "ENSP00000391478.2:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1208,
          "referenceAllele": "G",
          "start": 1207
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 957,
          "referenceAllele": "G",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 897,
          "referenceAllele": "G",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.619G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Glu207Lys",
        "hgvsWellDefined": "ENSP00000481179.1:p.Glu207Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1030,
          "referenceAllele": "G",
          "start": 1029
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 53,
          "endIntronDirection": "-",
          "endIntronOffset": 1003,
          "referenceAllele": "G",
          "start": 53,
          "startIntronDirection": "-",
          "startIntronOffset": 1004
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000576024.1:c.54-1004G>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS247265"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1265,
          "referenceAllele": "G",
          "start": 1264
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Glu300Lys",
        "hgvsWellDefined": "ENSP00000478219.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1208,
          "referenceAllele": "G",
          "start": 1207
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 957,
          "referenceAllele": "G",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 982,
          "referenceAllele": "G",
          "start": 981
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.982G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Glu328Lys",
        "hgvsWellDefined": "ENSP00000482903.1:p.Glu328Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1350,
          "referenceAllele": "G",
          "start": 1349
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1030,
          "referenceAllele": "G",
          "start": 1029
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 897,
          "referenceAllele": "G",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.538G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:p.Glu180Lys",
        "hgvsWellDefined": "ENSP00000484375.1:p.Glu180Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1151,
          "referenceAllele": "G",
          "start": 1150
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Glu300Lys",
        "hgvsWellDefined": "ENSP00000482537.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1205,
          "referenceAllele": "G",
          "start": 1204
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Glu300Lys",
        "hgvsWellDefined": "ENSP00000481638.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1281,
          "referenceAllele": "G",
          "start": 1280
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1158,
          "referenceAllele": "G",
          "start": 1157
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Glu300Lys",
        "hgvsWellDefined": "ENSP00000488924.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294519",
      "coordinates": [
        {
          "allele": "A",
          "end": 1217,
          "referenceAllele": "G",
          "start": 1216
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.1015G>A",
        "LRG_321t1:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Glu339Lys",
        "hgvsWellDefined": "NP_000537.3:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294520",
      "coordinates": [
        {
          "allele": "A",
          "end": 1214,
          "referenceAllele": "G",
          "start": 1213
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.1015G>A",
        "LRG_321t2:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Glu339Lys",
        "hgvsWellDefined": "NP_001119584.1:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1277,
          "referenceAllele": "G",
          "start": 1276
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.*34G>A",
        "LRG_321t4:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1350,
          "referenceAllele": "G",
          "start": 1349
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.*122G>A",
        "LRG_321t3:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294517",
      "coordinates": [
        {
          "allele": "A",
          "end": 897,
          "referenceAllele": "G",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.619G>A",
        "LRG_321t5:c.619G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Glu207Lys",
        "hgvsWellDefined": "NP_001119587.1:p.Glu207Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1030,
          "referenceAllele": "G",
          "start": 1029
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.*122G>A",
        "LRG_321t6:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 957,
          "referenceAllele": "G",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.*34G>A",
        "LRG_321t7:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294518",
      "coordinates": [
        {
          "allele": "A",
          "end": 1334,
          "referenceAllele": "G",
          "start": 1333
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.898G>A",
        "LRG_321t8:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001119590.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1277,
          "referenceAllele": "G",
          "start": 1276
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1350,
          "referenceAllele": "G",
          "start": 1349
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562760",
      "coordinates": [
        {
          "allele": "A",
          "end": 897,
          "referenceAllele": "G",
          "start": 896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.538G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Glu180Lys",
        "hgvsWellDefined": "NP_001263626.1:p.Glu180Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1030,
          "referenceAllele": "G",
          "start": 1029
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 957,
          "referenceAllele": "G",
          "start": 956
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826566240",
      "coordinates": [
        {
          "allele": "A",
          "end": 1217,
          "referenceAllele": "G",
          "start": 1216
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001263689.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567756",
      "coordinates": [
        {
          "allele": "A",
          "end": 1214,
          "referenceAllele": "G",
          "start": 1213
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001263690.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1217,
          "referenceAllele": "G",
          "start": 1216
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1290,
          "referenceAllele": "G",
          "start": 1289
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562760",
      "coordinates": [
        {
          "allele": "A",
          "end": 648,
          "referenceAllele": "G",
          "start": 647
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.538G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Glu180Lys",
        "hgvsWellDefined": "NP_001263626.1:p.Glu180Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 781,
          "referenceAllele": "G",
          "start": 780
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 708,
          "referenceAllele": "G",
          "start": 707
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826566240",
      "coordinates": [
        {
          "allele": "A",
          "end": 1157,
          "referenceAllele": "G",
          "start": 1156
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001263689.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567756",
      "coordinates": [
        {
          "allele": "A",
          "end": 1154,
          "referenceAllele": "G",
          "start": 1153
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001263690.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294519",
      "coordinates": [
        {
          "allele": "A",
          "end": 1157,
          "referenceAllele": "G",
          "start": 1156
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Glu339Lys",
        "hgvsWellDefined": "NP_000537.3:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.1015G>A"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.1015G>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Glu339Lys"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Glu339Lys"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA294520",
      "coordinates": [
        {
          "allele": "A",
          "end": 1154,
          "referenceAllele": "G",
          "start": 1153
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.1015G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Glu339Lys",
        "hgvsWellDefined": "NP_001119584.1:p.Glu339Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1217,
          "referenceAllele": "G",
          "start": 1216
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1290,
          "referenceAllele": "G",
          "start": 1289
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294517",
      "coordinates": [
        {
          "allele": "A",
          "end": 648,
          "referenceAllele": "G",
          "start": 647
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.619G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Glu207Lys",
        "hgvsWellDefined": "NP_001119587.1:p.Glu207Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 781,
          "referenceAllele": "G",
          "start": 780
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 708,
          "referenceAllele": "G",
          "start": 707
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "@id": "http://reg.genome.network/allele/PA294518",
      "coordinates": [
        {
          "allele": "A",
          "end": 1274,
          "referenceAllele": "G",
          "start": 1273
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001119590.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1217,
          "referenceAllele": "G",
          "start": 1216
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1290,
          "referenceAllele": "G",
          "start": 1289
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562760",
      "coordinates": [
        {
          "allele": "A",
          "end": 648,
          "referenceAllele": "G",
          "start": 647
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.538G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Glu180Lys",
        "hgvsWellDefined": "NP_001263626.1:p.Glu180Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 781,
          "referenceAllele": "G",
          "start": 780
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.*122G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.*122G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 708,
          "referenceAllele": "G",
          "start": 707
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.*34G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.*34G>A"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826566240",
      "coordinates": [
        {
          "allele": "A",
          "end": 1157,
          "referenceAllele": "G",
          "start": 1156
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001263689.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567756",
      "coordinates": [
        {
          "allele": "A",
          "end": 1154,
          "referenceAllele": "G",
          "start": 1153
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.898G>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Glu300Lys",
        "hgvsWellDefined": "NP_001263690.1:p.Glu300Lys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}